AutismKB 2.0

Annotation Detail for DOCK5


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Basic Information Top
Gene Symbol:DOCK5 ( DKFZp451J181,DKFZp779M164,DKFZp781J211 )
Gene Full Name: dedicator of cytokinesis 5
Band: 8p21.2
Quick LinksEntrez ID:80005; OMIM: NA; Uniprot ID:DOCK5_HUMAN; ENSEMBL ID: ENSG00000147459; HGNC ID: 23476
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DOCK5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of DOCK5 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of DOCK5 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DOCK5 mRNAdecreases expression 19150397
20018196
D002117 Calcitriol Calcitriol results in increased expression of DOCK5 mRNAincreases expression 16002434
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DOCK5 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DOCK5 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1118057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.1919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.1919483382
MESH:D001943 Breast Neoplasms Calcitriol 2.5711237771
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6911237771
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.4318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6811529661 11834606 12540782 19416960 10915739 11421492 19739265 11461765 14550746 12958197 11287661 16177239 17906064 16109766 15619225 15968718 17562736 14986274 10663392 16081117 12594235 16227642 19164858 19085960 19420014 12705907 18713872 17522070 11739529 14725611 19370779 16781746 11743745 10774834 16393943 18071297 16485898 19923254 2444490 12153990 12392966
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.6818218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Amiodarone 8.9114986274
MESH:D005234 Fatty Liver pirinixic acid 8.9119236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly Amiodarone 10.0015265979
MESH:D006529 Hepatomegaly pirinixic acid 10.0018467677 19772884 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.208137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007037 Hypothyroidism Amiodarone 4.9318020914 17991464
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2416705839
MESH:D008064 Lipidoses Amiodarone 3.7317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 12587719 19460945 11587558 19014921 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.9116377806 20007298 15890375
MESH:D008133 Long QT Syndrome Amiodarone 3.8217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009181 Mycoses Amiodarone 5.4217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.3218551238
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7316049721 12819281
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4916644109 18247401 12479363 15754350 16289102
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9512490602 12832656 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7318551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.6517467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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