AutismKB 2.0

Annotation Detail for GLRA3


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Basic Information Top
Gene Symbol:GLRA3 ( - )
Gene Full Name: glycine receptor, alpha 3
Band: 4q34.1
Quick LinksEntrez ID:8001; OMIM: 600421; Uniprot ID:GLRA3_HUMAN; ENSEMBL ID: ENSG00000145451; HGNC ID: 4328
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C095105 bexarotene bexarotene results in increased expression of GLRA3 mRNAincreases expression 16648578
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLRA3 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of GLRA3 mRNAincreases expression 19619570
D008628 Mercury Mercury results in increased expression of GLRA3 mRNAincreases expression 16823088
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GLRA3 mRNAaffects binding|increases activity|increases expression 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of GLRA3 mRNAincreases expression 17879257
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLRA3 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLRA3 mRNAdecreases expression 19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4216712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001321 Autistic Disorder Mercury 2.7617497416
MESH:D001327 Autoimmune Diseases Mercury 5.2916634805
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms bexarotene 1.9216818667 16344269
MESH:D001943 Breast Neoplasms Estradiol 1.9212948864 14630087 17289903 17018787 16675129 19861407 18497071 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1616924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.1616507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.3116247446
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.5410334427
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4420056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 16354765 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.2016823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema pirinixic acid 7.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.1711473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly pirinixic acid 9.6916221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6915340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 16354765 15340226 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1912646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.8416627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Estradiol 11.1915618244
MESH:D007674 Kidney Diseases Mercury 11.1917934191
MESH:D007674 Kidney Diseases sodium arsenite 11.1920008137
MESH:D007680 Kidney Neoplasms Estradiol 3.2415610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.9415890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.9416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms bexarotene 3.6517849452
MESH:D008175 Lung Neoplasms sodium arsenite 3.6517077188 16712894 15276417 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6519555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.5611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.8915591091 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8916891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D008545 Melanoma sodium arsenite 2.0619082730 16487513
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D009369 Neoplasms pirinixic acid 5.4017405874
MESH:D009369 Neoplasms sodium arsenite 5.4011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.3019196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Estradiol 10.7711399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.7714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010051 Ovarian Neoplasms Estradiol 5.1119401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.1117306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1616740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1616039940
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms sodium arsenite 6.0218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6017306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
DB00431 antagonist Dermadex Crm Antiscabies Agent;Scabicide;Insecticides
DB00466 antagonist Picrotoxin Central Nervous System Stimulants;Stimulants;Anti-barbituates;GABA receptor antagonists;Antidotes;Convulsants;GABA Antagonists
DB00602 agonist Heel 170 Tab Anthelmintics;Antiprotozoal Agents;Antinematodal Agents
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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