AutismKB 2.0

Annotation Detail for WWC2


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Basic Information Top
Gene Symbol:WWC2 ( BOMB,FLJ22029,FLJ34082 )
Gene Full Name: WW and C2 domain containing 2
Band: 4q35.1
Quick LinksEntrez ID:80014; OMIM: NA; Uniprot ID:WWC2_HUMAN; ENSEMBL ID: ENSG00000151718; HGNC ID: 24148
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WWC2 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WWC2 mRNAdecreases expression 20018196
C004541 biochanin A biochanin A results in decreased expression of WWC2 mRNAdecreases expression 12111696
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of WWC2 mRNAincreases expression 17484886
C025643 vinclozolin vinclozolin affects the expression of WWC2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2618705752 15700767 16097048 16050911 16011737 16192424 16124888 15673190 16227642 10355542 3786805 15721981
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.1110915739 7120509 15027814 19336974 7179309 4309450 6884620 16177239 10092053 17522070 11566570 7440962 19085960 15998439 15968718 3786805 16227642 3732212 6623471 2869522 21278145 9327722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5416045604 16239168 61145 12631006 19224547 15959796 17595544 12795759
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005909 Glioblastoma biochanin A 4.6716598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811903743 16239168 16943688 17334410 17174718 16221502 11408273 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7512389079 17766677 18395095 15673190 18420326 15876570 17481882 15996030 17869086 10355542 18472094 13678700 16033810 17640975 17823541 12741479 18481824 12632514 12609069 12586293 18006644 18395914 17698563 16027843 15057751 17976157 17900296 12667390 12666154 18412020 14512876 15338365 15370692 18210741 18277467 16011737 12649538 18205269 18705752 17714472 18166357 12958196 15925388 17565644 16097048 18376398 18472332 18418968 12445418 18251166 14716496 18317297 16015684 15893842 14716833 15650968 16136751 16116963 17922224 15959796 15931870 17525996 14748882 18279442 14620537 17557913 16638106 15818738 17944888 17805973 11481614 18263696 16248980 17631135 12546737 16192424 12632512 18429990 17721639 17708605 18187930 18339082 14724832 17761835 15362042 18156304 15730626 15123356 12445421 18054572 20821823 12898905 15052691
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 16246199 15720792 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0414706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8819294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5717053015 20064080 18520028 6695378 20464547 20869020 18816296 20135361 18569708
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.6117292933
MESH:D011471 Prostatic Neoplasms biochanin A 3.6112111696
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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