AutismKB 2.0

Annotation Detail for NR4A3


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Basic Information Top
Gene Symbol:NR4A3 ( CHN,CSMF,MINOR,NOR1,TEC )
Gene Full Name: nuclear receptor subfamily 4, group A, member 3
Band: 9q22
Quick LinksEntrez ID:8013; OMIM: 600542; Uniprot ID:NR4A3_HUMAN; ENSEMBL ID: ENSG00000119508; HGNC ID: 7982
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Gene Expression
No data
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Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of soft tissues and bone
H00053Extraskeletal myxoid chondrosarcoma
No data
No data
No data
Desease Name
Chondrosarcoma, extraskeletal myxoid
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of NR4A3 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NR4A3 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NR4A3 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of NR4A3 mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of NR4A3 mRNAincreases expression 18687144
D001205 Ascorbic Acid [Tretinoin co-treated with Ascorbic Acid] results in increased expression of NR4A3 mRNAaffects cotreatment|increases expression 16443354
D016589 Astemizole Astemizole results in increased expression of NR4A3 mRNAincreases expression 20221588
D001280 Atrazine Atrazine results in increased expression of NR4A3 mRNAincreases expression 18461179
C006780 bisphenol A bisphenol A results in increased expression of NR4A3 mRNAincreases expression 14967926
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of NR4A3 mRNAincreases expression 17553608
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of NR4A3 mRNAaffects cotreatment|decreases expression 18636392
D003847 Deoxyglucose NR4A3 protein promotes the reaction [[INS protein results in increased localization of SLC2A4 protein] which results in increased uptake of Deoxyglucose]increases localization|increases reaction|increases uptake 17785466
D003847 Deoxyglucose NR4A3 protein promotes the reaction [INS protein results in increased uptake of Deoxyglucose]increases reaction|increases uptake 17785466
C056507 gemcitabine gemcitabine results in increased expression of NR4A3 mRNAincreases expression 17039268
D006220 Haloperidol Haloperidol results in increased expression of NR4A3 mRNAincreases expression 19695244
D009151 Mustard Gas Mustard Gas results in increased expression of NR4A3 mRNAincreases expression 18988085
C521676 N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine N-((2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)-benzylamine results in increased expression of NR4A3 mRNAincreases expression 19695244
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NR4A3 mRNAincreases expression 17616710
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of NR4A3 mRNAaffects cotreatment|decreases expression 18636392
D010126 Ozone Ozone results in increased expression of NR4A3 mRNAincreases expression 16716893
D026023 Permethrin Permethrin results in increased expression of NR4A3 mRNAincreases expression 19017407
D010656 Phenylephrine Phenylephrine results in increased expression of NR4A3 mRNAincreases expression 18158353
C060836 pioglitazone pioglitazone results in increased expression of NR4A3 mRNAincreases expression 17785466
C006253 pirinixic acid pirinixic acid results in increased expression of NR4A3 mRNAincreases expression 16985257
D011794 Quercetin Quercetin affects the expression of NR4A3 mRNAaffects expression 18178720
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of NR4A3 mRNAaffects cotreatment|increases expression 19059307
C410733 scriptaid scriptaid affects the expression of NR4A3 mRNAaffects expression 18813790
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of NR4A3 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NR4A3 mRNAincreases expression 19933214
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A3 mRNAaffects cotreatment|affects expression 16979875
D014212 Tretinoin [Tretinoin co-treated with Ascorbic Acid] results in increased expression of NR4A3 mRNAaffects cotreatment|increases expression 16443354
C057693 troglitazone troglitazone results in increased expression of NR4A3 mRNAincreases expression 17785466
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of NR4A3 mRNAincreases expression 19465080
C025643 vinclozolin vinclozolin affects the expression of NR4A3 mRNAaffects expression 19015723
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of NR4A3 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5315322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000169 Acrodermatitis Zinc 5.0816889938 17190629 17202136
MESH:D055371 Acute Lung Injury Chlorine 8.1520601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.1518653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.563712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.8817306315
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.9011874814
MESH:D000419 Albuminuria Raloxifene 4.2917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000544 Alzheimer Disease Ozone 6.2615513908
MESH:D000544 Alzheimer Disease Raloxifene 6.2615800139
MESH:D000544 Alzheimer Disease Zinc 6.2617119284 16325427 16410023 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9517084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.5916916123
MESH:D000799 Angioedema Astemizole 5.332883202
MESH:D001008 Anxiety Disorders vinclozolin 3.3919015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8317460149
MESH:D020261 Arsenic Poisoning Arsenic 2.7712569548 16251483 18414634 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 2.8816412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3915570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3916292516
MESH:D001249 Asthma Mustard Gas 10.4410378619
MESH:D001249 Asthma Ozone 10.4417854713 16373670
MESH:D001249 Asthma Tretinoin 10.4416456186
MESH:D001249 Asthma Zinc 10.4417085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6515336622
MESH:D050197 Atherosclerosis Arsenic 3.0612928151 19371607
MESH:D001321 Autistic Disorder Haloperidol 2.8718080171 19368416
MESH:D001321 Autistic Disorder pioglitazone 2.8717207275
MESH:D001327 Autoimmune Diseases Quercetin 4.0919761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.6911289319 1440618
MESH:D001768 Blister Mustard Gas 4.8319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.5916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D001919 Bradycardia Phenylephrine 4.2215306635
MESH:D001930 Brain Injuries Raloxifene 10.0616580743
MESH:D001930 Brain Injuries Zinc 10.0617109824
MESH:D001943 Breast Neoplasms Ascorbic Acid 5.4816443354
MESH:D001943 Breast Neoplasms bisphenol A 5.4817123778
MESH:D001943 Breast Neoplasms Deoxyglucose 5.4818985042
MESH:D001943 Breast Neoplasms gemcitabine 5.4818382427 17039268
MESH:D001943 Breast Neoplasms Quercetin 5.4818628248
MESH:D001943 Breast Neoplasms Raloxifene 5.4817893378 15758505 17595753 17242785 16837676 17049068 16912660 17440819 15775269 17952589 17261762 15572757
MESH:D001943 Breast Neoplasms Tamoxifen 5.4818984771 15668708 19487384 11161223 16873071 15565566 19142967 18815881 20005174 19189212 19289846 18351453 19244106 19200415 16273361 17261762 18425577 19288272 16202921 19189210 19103187 20390343 18629630 19115204 19410462 19221464 17440819 17893378 19059307 19155303 21138602 20544844 20859285 19011961 17242785 20135344 18997820 21152245 17049068 19084267 18821012 16818667 20065188 18855134 19066611
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.4816166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4214754758 15516495 17626835 18315731 16777450 18417511 19059883
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2616813970
MESH:D002100 Cachexia Ozone 4.4116183385
MESH:D002105 Cadmium Poisoning Quercetin 5.2116962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4117687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.267296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.2617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.2612508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.2616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.261917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6417234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.527296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.0315504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 10.0318922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.0316096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 10.0316543248
MESH:D002295 Carcinoma, Transitional Cell Arsenic 14.2918640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 14.2917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 14.2917572228
MESH:D006332 Cardiomegaly Phenylephrine 10.4215728586 11754973 17124262 11179087 17287366 16170337
MESH:D006332 Cardiomegaly Quercetin 10.4219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.4218670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 11.0015738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 11.0015775269
MESH:D002318 Cardiovascular Diseases Zinc 11.0016936243
MESH:D002340 Carotid Artery Diseases Arsenic 4.0418022660 16973168
MESH:D002375 Catalepsy Haloperidol 4.5815215559 1977408
MESH:D002386 Cataract Tretinoin 2.9017460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.547505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.059022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.0519176532
OMIM:612237 CHONDROSARCOMA, EXTRASKELETAL MYXOID marker/mechanism
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3015340226 8697196 15668235 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.309407595
MESH:D003072 Cognition Disorders Raloxifene 4.3015800139
MESH:D003092 Colitis Tretinoin 3.3917035595
MESH:D003110 Colonic Neoplasms Quercetin 2.3611134977 16640504 17148506 19440933 15741050 17191121 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818095365 18852136
MESH:D003139 Common Cold Ascorbic Acid 5.1417323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D019465 Craniofacial Abnormalities Permethrin 5.1619861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.169125849 16925845 10589399 9211117 17551590 9224671 8800419 9664655 14991402 9142499
MESH:D019465 Craniofacial Abnormalities Zinc 5.1619302082
MESH:D003456 Cryptorchidism vinclozolin 4.0314966744
MESH:D003550 Cystic Fibrosis pioglitazone 4.6419747007
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5420210726
MESH:D003704 Dementia Haloperidol 4.2911575062
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8917474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5012868966 8970840 18759878 2524372 14531868 11298694 11906362 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 8.673621924 2952479
MESH:D003877 Dermatitis, Contact Permethrin 8.6714617103
MESH:D003920 Diabetes Mellitus Zinc 3.9316479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4719496084
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 9.6816506275
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 9.6812642470 16023994
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.6817107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 9.6816023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.3112601628
MESH:D003928 Diabetic Nephropathies Raloxifene 8.1317451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1319279558
MESH:D004244 Dizziness Astemizole 6.133105558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.7618648102 11289319 18289764 16192314 8291058 1440618 9653073 9328219 18692083 6679447 9022650 6482804 7440962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7620420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 5.7614986274
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004417 Dyspnea Chlorine 4.3020016425
MESH:C538011 Eales disease Ascorbic Acid 5.149068938
MESH:D004487 Edema Mustard Gas 18.599260866 11428631 11428647 11402378
MESH:D004487 Edema pirinixic acid 18.5912083418
MESH:D004487 Edema Raloxifene 18.5915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 18.5912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 18.599599246 15177302 16716910 11698051 8273558 8113982 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.2215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7320544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.749294722 10568697
MESH:D004802 Eosinophilia Astemizole 4.491355641
MESH:D004890 Erythema Mustard Gas 4.839357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.863581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.8615878914 16805852 15547733 16510608 15150132 15264214 15623463 15547721 16704527
MESH:D004938 Esophageal Neoplasms Zinc 6.8616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.049664655 16938888
MESH:D005234 Fatty Liver pirinixic acid 11.4719236843 20131406
MESH:D005234 Fatty Liver Raloxifene 11.4717473493
MESH:D005234 Fatty Liver Tamoxifen 11.4714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.696705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8619069698
MESH:D005355 Fibrosis Quercetin 12.9819474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9820067830
MESH:D005355 Fibrosis Tretinoin 12.9817994277
MESH:D005499 Folliculitis Astemizole 5.591671328
MESH:D005534 Foot Diseases Arsenic 5.236392382
MESH:D005739 Gas Poisoning Chlorine 4.6820016425
MESH:D005756 Gastritis Zinc 4.4717241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6116973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9716417039
MESH:D005909 Glioblastoma Quercetin 6.5519804834
MESH:D005909 Glioblastoma Tretinoin 6.5517312396
MESH:D005910 Glioma Quercetin 2.9217643826
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 4.9916687628
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.747505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006130 Growth Disorders Zinc 3.7517217573
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 10.2316080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.2310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.2314991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.3111110106
MESH:D006333 Heart Failure pirinixic acid 6.4820558911
MESH:D006333 Heart Failure Zinc 6.4817162251
MESH:D006335 Heart Injuries Zinc 5.4417074742
MESH:D016481 Helicobacter Infections Zinc 4.2317241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.216705139
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3717276780
MESH:D006529 Hepatomegaly pirinixic acid 7.2119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.3616490937 16863852
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7115340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Tretinoin 2.9616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006943 Hyperglycemia pirinixic acid 8.3120558911
MESH:D006943 Hyperglycemia Quercetin 8.3118262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1717050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6215034207
MESH:D006973 Hypertension Arsenic 15.0316076760 11953799 9931084
MESH:D006973 Hypertension Phenylephrine 15.0312717712 8949925
MESH:D006973 Hypertension Quercetin 15.0318356687
MESH:D006973 Hypertension Raloxifene 15.0315787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.0318850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.2618502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.2316093927
MESH:D007248 Infertility, Male Atrazine 6.3912948887
MESH:D007248 Infertility, Male vinclozolin 6.3916467254
MESH:D007249 Inflammation Mustard Gas 14.069357497 11428647 11428631 9260866 11402378 11428620 17524151 8975870 16001271
MESH:D007249 Inflammation pioglitazone 14.0616908763
MESH:D007249 Inflammation Tamoxifen 14.0619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.0612878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 14.067562506 7812673 15177302 8273558 11698051
MESH:D007251 Influenza, Human Quercetin 4.1816624496
MESH:D007299 Insect Bites and Stings Permethrin 5.4912749493 15189238 12971516
MESH:D007333 Insulin Resistance marker/mechanism 17785466
MESH:D007333 Insulin Resistance bisphenol A 6.6116393666
MESH:D007333 Insulin Resistance pirinixic acid 6.6116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4517994277
MESH:D007511 Ischemia Zinc 4.3116584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.698074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9717551590 15992940
MESH:D007627 Keloid Quercetin 4.6417086741
MESH:D007642 Keratosis Arsenic 4.6616930632 12749816
MESH:D007674 Kidney Diseases Quercetin 5.8616962696
MESH:D007674 Kidney Diseases Zinc 5.8616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1316518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.526582329
MESH:D007680 Kidney Neoplasms Tamoxifen 6.5218625569
MESH:D007889 Leiomyoma Raloxifene 4.2016973256
MESH:D007938 Leukemia Permethrin 9.7312937054
MESH:D007938 Leukemia Quercetin 9.7317468513
MESH:D007938 Leukemia Tretinoin 9.7317143497
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 5.8116085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4116932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.0517339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0517361223 16331271 16891316 17506722 19075265 19225113 17712046 17301526 17649720 16140955 16788101 17368321 19035177 19029980 16823087 16766008 17294898 17217047 9834237 16935935 15748426 19642359 17339181 12679006 17107899
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4116417039
MESH:D017513 Lichen Nitidus Astemizole 6.132563723
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.089224671
MESH:D008064 Lipidoses Tamoxifen 2.9317567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9915034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 8.1516484506 15052691
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1515474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 8.1512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.1518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.1516248980 18397230
MESH:D008107 Liver Diseases Arsenic 2.4611134558
MESH:D008113 Liver Neoplasms Arsenic 12.8616368122
MESH:D008113 Liver Neoplasms pirinixic acid 12.8620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 12.8618980244
MESH:D008113 Liver Neoplasms Tamoxifen 12.8616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.8616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.49598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 12.4918544905
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.4919519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.4912151625
MESH:D008133 Long QT Syndrome Astemizole 4.3518472280 11989578
MESH:D008171 Lung Diseases Ascorbic Acid 11.2516863852
MESH:D008171 Lung Diseases Mustard Gas 11.2518161513 18702808
MESH:D008171 Lung Diseases Ozone 11.258266340 19066396
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.1917365036
MESH:D055370 Lung Injury Ozone 8.1920417186
MESH:D008175 Lung Neoplasms Arsenic 14.5217306315 17976673 19168569
MESH:D008175 Lung Neoplasms Ascorbic Acid 14.5216401635
MESH:D008175 Lung Neoplasms Mustard Gas 14.528781369 3148597
MESH:D008175 Lung Neoplasms Ozone 14.527614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 14.5216280456
MESH:D008175 Lung Neoplasms Tamoxifen 14.5218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.5219555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 14.5211807781
MESH:D008175 Lung Neoplasms Vehicle Emissions 14.529255578
MESH:D008288 Malaria Astemizole 4.5216816845
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.9314580682 16827153 11731420 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 8.938985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.9312773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.2219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma Tamoxifen 3.0919393235 12393984
MESH:D008545 Melanoma Tretinoin 3.0916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D001523 Mental Disorders Haloperidol 3.7016856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.1618303189 16166281 16966607
MESH:D008654 Mesothelioma Atrazine 6.161916698
MESH:D008679 Metaplasia Ozone 4.7710496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2215863610
MESH:D009101 Multiple Myeloma Raloxifene 3.2116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8917596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D009203 Myocardial Infarction Quercetin 5.2619595682
MESH:D017202 Myocardial Ischemia Arsenic 8.1515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1512213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6216411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.6219207477
MESH:D009232 Myxoma Raloxifene 5.2216343187
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.243581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.2419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms pirinixic acid 7.3217405874
MESH:D009369 Neoplasms Quercetin 7.3215185748
MESH:D009369 Neoplasms Tretinoin 7.3216946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6719200415 19189210 19196722
MESH:D009421 Nervous System Malformations bisphenol A 14.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.5814600291
MESH:D009421 Nervous System Malformations Tretinoin 14.589125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 10.946679447
MESH:D009436 Neural Tube Defects Arsenic 10.9416620997
MESH:D009436 Neural Tube Defects Tretinoin 10.949142499
MESH:D020078 Neurogenic Inflammation Arsenic 9.6917056641
MESH:D020078 Neurogenic Inflammation Quercetin 9.6917929310
MESH:D009503 Neutropenia Mustard Gas 3.6716761898 7688884
MESH:D009759 Nystagmus, Pathologic Astemizole 6.136135121
MESH:D009765 Obesity Ascorbic Acid 4.4517217161
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.144026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.693988306
MESH:D010024 Osteoporosis Raloxifene 3.2019059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.1919495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1915579764 17823083 15758505 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms Arsenic 7.3517306315
MESH:D010051 Ovarian Neoplasms Quercetin 7.3519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.3516936753
MESH:D010146 Pain Tretinoin 2.6516870215
MESH:D010190 Pancreatic Neoplasms gemcitabine 11.4218992248 17440100 18383843 11504793 16929163
MESH:D010190 Pancreatic Neoplasms Quercetin 11.4216965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.4215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.4215976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.347296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.3412065085 18922899 18404319 8330346
MESH:D010300 Parkinson Disease Atrazine 3.1517218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6616905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.8116369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.146228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.5710923243
MESH:D011014 Pneumonia Ozone 4.0718007984 18381685 18929643
MESH:D011041 Poisoning Mustard Gas 3.5015727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Quercetin 3.7119056647
MESH:D011225 Pre-Eclampsia Zinc 3.9317114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.3610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.3611399792 11896295 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.3619015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6118220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9220887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0516140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0516740699
MESH:D011471 Prostatic Neoplasms Deoxyglucose 2.0518985042
MESH:D011471 Prostatic Neoplasms Quercetin 2.0514715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0516536755 16220300 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0515067354
MESH:D011471 Prostatic Neoplasms Zinc 2.0512429649 16606632 16517595 16700911
MESH:D011472 Prostatitis vinclozolin 4.6118629315
MESH:D011507 Proteinuria Arsenic 13.9021343184
MESH:D011507 Proteinuria pioglitazone 13.9016687628
MESH:D011507 Proteinuria Tretinoin 13.9016636307
MESH:D011537 Pruritus Mustard Gas 3.7718058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.6411575062
MESH:D011618 Psychotic Disorders Haloperidol 4.0211575062
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.0014606601
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 8.7415814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.7417266442 10334151 17894541 17620002 17720292
MESH:D011658 Pulmonary Fibrosis troglitazone 8.7418162602
MESH:D011693 Purpura Raloxifene 5.2215770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D012120 Respiration Disorders Chlorine 4.8818579056
MESH:D012135 Respiratory Sounds Atrazine 9.2711874814
MESH:D012135 Respiratory Sounds Vehicle Emissions 9.2718950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.213692021
MESH:D012162 Retinal Degeneration Zinc 8.2116584753
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2216849425
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8016116481 16283617
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.1010822083
MESH:D012554 Schistosomiasis japonica Quercetin 5.2116862918
MESH:D012559 Schizophrenia Haloperidol 2.7620107430 18513383 19369910 1830565
MESH:D012640 Seizures Deoxyglucose 4.3917978042
MESH:D012852 Sinusitis Phenylephrine 4.387327846
MESH:D012871 Skin Diseases Arsenic 7.576392382 17938729 19834688 17548696 18709164 17050553 16702368 17453740 15952646 16353154 16759981
MESH:D012871 Skin Diseases Ascorbic Acid 7.5718709164
MESH:D012871 Skin Diseases Mustard Gas 7.5712880345 16961503 15451306
MESH:D012878 Skin Neoplasms Arsenic 12.3117029826 17976673 19538983 15504454 17050553 16251483
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.318330346 11807781 18404319 12065085 8985016
MESH:D012878 Skin Neoplasms Tretinoin 12.3116467112
MESH:D013088 Spermatocele Tamoxifen 3.9616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7119457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4217575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 3.4217261132
MESH:D013274 Stomach Neoplasms troglitazone 3.4215930296
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.6118726076
MESH:D020521 Stroke Ascorbic Acid 8.1516403987 16517955
MESH:D020521 Stroke Raloxifene 8.1516837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.4020210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.326587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.3217045167 16026305
MESH:D013978 Tibial Fractures Raloxifene 4.8819048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.0416051514
MESH:D014062 Tongue Neoplasms Zinc 9.0416543248
MESH:D016171 Torsades de Pointes Astemizole 4.889583453 8256756
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 18.178074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.1717976673 15987713 18640142 11144890 19429237 17306315 19322015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.1716720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 18.1717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.1716712894 17572228 8653321
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 18.1711144890
MESH:D014581 Urticaria Astemizole 4.502568013 3080510 2859714 2568189 2883202 2565098 1976298 1683191 2147912 3097109 3134034 2885854
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4016129372
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.2816752155
MESH:D014652 Vascular Diseases Arsenic 4.4117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8816837676
MESH:D014717 Vertigo Astemizole 6.133105558
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
Pathway ID Pathway Name
REACT:71 Gene Expression
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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