AutismKB 2.0

Annotation Detail for FRAS1


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Basic Information Top
Gene Symbol:FRAS1 ( DKFZp686I05113,DKFZp686P08111,FLJ14927,FLJ22031,KIAA1500 )
Gene Full Name: Fraser syndrome 1
Band: 4q21.21
Quick LinksEntrez ID:80144; OMIM: 607830; Uniprot ID:FRAS1_HUMAN; ENSEMBL ID: ENSG00000138759; HGNC ID: 19185
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
DEVELOPMENTAL
hair morphology
Desease Name
Hair morphology
Desease Name
Fraser syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of FRAS1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of FRAS1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FRAS1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of FRAS1 mRNAincreases expression 19774075
D001104 Arbutin Arbutin results in decreased expression of FRAS1 mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FRAS1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FRAS1 mRNAincreases expression 17942748
D009151 Mustard Gas Mustard Gas affects the expression of FRAS1 mRNAaffects expression 15651846
C024746 tobacco tar tobacco tar results in increased expression of FRAS1 mRNAincreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3214692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001281 Atrial Fibrillation Amiodarone 4.0519698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1119483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2917687719 10378619
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.697296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6921507988 12907637 12619106
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9519225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.557505956
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.5519559774
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.369022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.3615861022 16919318 17110522 17681005 11677210 17333356 16105132
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0611906362 11298694 12868966 8970840 8156756 2524372 14531868 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5418692083 9022650 18289764 7440962 6482804 18648102 11289319 6679447 8291058 9328219 1440618 9653073 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5412958197 11834606 16109766 16227642 16393943 14725611 12392966 16781746 16081117 18071297 19085960 11461765 16177239 19416960 16485898 11287661 11529661 14986274 18713872 15968718 19923254 17522070 19164858 10915739 10774834 11421492 19370779 12705907 15619225 19739265 11743745 19420014 12594235 2444490 17562736 11739529 12540782 14550746 17906064 12153990 10663392
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.5418218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004487 Edema Mustard Gas 3.5111428631 9260866 11402378 11428647
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D005234 Fatty Liver Amiodarone 8.5114986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D058497 Fraser Syndrome marker/mechanism 17163535
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Amiodarone 4.0115265979
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.089751232 8137927
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.7717991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Mustard Gas 2.888975870 11428647 17524151 16001271 9260866 11402378 11428620 9357497 11428631
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D008064 Lipidoses Amiodarone 3.6517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6712587719 19014921 11587558 12969438 19784758 19460945 16611625 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.7918177683 9163691 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7921137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.37598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.378603461
MESH:D008133 Long QT Syndrome Amiodarone 3.7311989578 17391786 15350150
MESH:D008171 Lung Diseases Amiodarone 8.0612587719
MESH:D008171 Lung Diseases Mustard Gas 8.0618702808 18161513
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5918569708 20869020 18816296 6695378 20464547 20064080 18520028 17053015 20135361
MESH:D008175 Lung Neoplasms Mustard Gas 3.598781369 3148597
MESH:D008265 Macrostomia marker/mechanism 17163535
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009181 Mycoses Amiodarone 5.2212754197 17974566
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009503 Neutropenia Mustard Gas 4.1916761898 7688884
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D011537 Pruritus Ethinyl Estradiol 10.4915861022 16919318
MESH:D011537 Pruritus Mustard Gas 10.4918058305
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.0712490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Mustard Gas 6.0710334151 17266442 17720292 17894541 17620002
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 16961503 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Amiodarone 5.0819731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.047505956 6582329 3712494 1399818 6587162
MESH:D013971 Thyrotoxicosis Amiodarone 5.1219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.4711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.208074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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