AutismKB 2.0

Annotation Detail for EDC3


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Basic Information Top
Gene Symbol:EDC3 ( FLJ21128,FLJ31777,LSM16,YJDC,YJEFN2 )
Gene Full Name: enhancer of mRNA decapping 3 homolog (S. cerevisiae)
Band: 15q24.1
Quick LinksEntrez ID:80153; OMIM: 609842; Uniprot ID:EDC3_HUMAN; ENSEMBL ID: ENSG00000179151; HGNC ID: 26114
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
No data
No data
Pathway IDPathway Name
500857mRNA Decay by 5' to 3' Exoribonuclease
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of EDC3 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EDC3 mRNAdecreases expression 20127859
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EDC3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of EDC3 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EDC3 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EDC3 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of EDC3 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of EDC3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EDC3 mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EDC3 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.3511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9518497071 17261762 12948864 19861407 17289903 14630087 17018787 16675129
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519189212 19011961 18997820 16202921 16818667 18855134 19084267 11161223 18984771 17893378 19103187 19115204 19200415 18815881 17261762 20135344 17440819 19142967 17242785 18629630 20005174 15668708 19244106 15565566 19288272 20544844 17049068 19221464 19059307 19289846 20390343 19155303 19066611 18425577 20859285 18351453 19410462 21152245 21138602 19189210 19487384 20065188 16873071 16273361 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0916924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4211677210 17110522 16919318 17333356 15861022 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15340226 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.6819279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.6819279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.9618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.9617893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 14.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 18606429 8697196 16354765 15340226
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.7716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.7716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 8.1815610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.1818625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4120195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 11.4116377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 11.4116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4817053015 18816296 20135361 18569708 6695378 20464547 18520028 20064080 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.5316891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.5311731420 14580682 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.1719453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.1719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.9616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2211141357
MESH:D009369 Neoplasms pirinixic acid 5.2217405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11222880 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4517292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4516740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4515067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3017053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3017572228 8653321 16712894
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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