AutismKB 2.0

Annotation Detail for FBXO11


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Basic Information Top
Gene Symbol:FBXO11 ( FBX11,FLJ12673,MGC44383,PRMT9,UBR6,VIT1 )
Gene Full Name: F-box protein 11
Band: 2p16.3
Quick LinksEntrez ID:80204; OMIM: 607871; Uniprot ID:FBX11_HUMAN; ENSEMBL ID: ENSG00000138081; HGNC ID: 13590
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200175p53 pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
2096Otitis media
Desease Name
Otitis Media
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FBXO11 mRNAaffects expression 21346803
D001104 Arbutin Arbutin results in increased expression of FBXO11 mRNAincreases expression 17103032
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FBXO11 mRNAdecreases expression 20018196
19150397
D016572 Cyclosporine Cyclosporine results in increased expression of FBXO11 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of FBXO11 mRNAaffects expression 17555576
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of FBXO11 mRNAincreases expression 17616710
D011374 Progesterone Progesterone results in increased expression of FBXO11 mRNAincreases expression 18037150
D012643 Selenium Selenium results in decreased expression of FBXO11 mRNAdecreases expression 19244175
D013629 Tamoxifen Tamoxifen affects the expression of FBXO11 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215845082 15665606 15380490
MESH:D001943 Breast Neoplasms Progesterone 2.2115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 2.2119244106 17261762 19200415 19084267 16273361 20390343 16818667 21152245 20859285 19011961 19288272 15668708 18997820 20135344 21138602 17893378 18821012 18815881 17242785 19189212 19059307 19142967 19066611 19155303 19103187 18629630 18425577 19221464 19289846 20544844 17049068 16202921 19487384 19115204 20005174 19189210 18984771 11161223 18351453 15565566 18855134 19410462 17440819 20065188 16873071
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0616705839
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.956135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.9520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9512371664
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2817333356 16105132 17110522 11677210 15861022 17681005 16919318
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.7719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1719155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7820426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7815878914 16805852 15547733 15150132 16510608 15547721 15264214 16704527 15623463
MESH:D005234 Fatty Liver Cyclosporine 14.2919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.2915345470
MESH:D005234 Fatty Liver Tamoxifen 14.2919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Progesterone 5.4915869954
MESH:D007249 Inflammation Tamoxifen 5.4919457130
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.4012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4018625569
MESH:D008064 Lipidoses Tamoxifen 3.3015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.787678174
MESH:D008113 Liver Neoplasms Tamoxifen 4.7816684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.662876786 6135515 2876784
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.7411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.7415318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.7411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.8415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.8419457130
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3312958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2716049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2717572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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