AutismKB 2.0

Annotation Detail for NUBPL


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Basic Information Top
Gene Symbol:NUBPL ( C14orf127,FLJ12660,IND1,huInd1 )
Gene Full Name: nucleotide binding protein-like
Band: 14q12
Quick LinksEntrez ID:80224; OMIM: 613621; Uniprot ID:NUBPL_HUMAN; ENSEMBL ID: ENSG00000151413; HGNC ID: 20278
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
response to iloperidone treatment (QT prolongation)
PHARMACOGENOMIC
Brain lesion load
NEUROLOGICAL
Desease Name
Brain lesion load
Response to iloperidone treatment (QT prolongation)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NUBPL mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NUBPL mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NUBPL mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NUBPL proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NUBPL mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUBPL mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of NUBPL mRNAdecreases expression 20106945
D018038 Sodium Selenite Sodium Selenite results in decreased expression of NUBPL mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8212907637 12619106 21507988
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.086135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.0820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.0812371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.492444490 18071297 19923254 15619225 19164858 12153990 11287661 11739529 16393943 14550746 19370779 11743745 16177239 12540782 12705907 12392966 16081117 14725611 11421492 19420014 15968718 11461765 11834606 11529661 10915739 16781746 17562736 18713872 16109766 19416960 19085960 10774834 16485898 10663392 17906064 17522070 12958197 16227642 14986274 19739265 12594235
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.4915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 19460945 12587719 12969438 16610002 16611625 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.907678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9015890375 2125692 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9020195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.442876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.448603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.476695378 20464547 18816296 18520028 20064080 17053015 20869020 18569708 20135361
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
OMIM:252010 MITOCHONDRIAL COMPLEX I DEFICIENCY marker/mechanism
MESH:D028361 Mitochondrial Diseases marker/mechanism 20818383
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2711141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1717292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1718760546
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134907818
    • No data
    Releated disease ID Related disease Name
    PA447300Acquired Long QT Syndrome (aLQTS)
    PA447228congenital long QT syndrome
    PA444807Long QT Syndrome
    Releated drug ID Related drug Name
    PA161199368iloperidone
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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