AutismKB 2.0

Annotation Detail for STAM


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Basic Information Top
Gene Symbol:STAM ( DKFZp686J2352,STAM1 )
Gene Full Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Band: 10p12.33
Quick LinksEntrez ID:8027; OMIM: 601899; Uniprot ID:STAM1_HUMAN; ENSEMBL ID: ENSG00000136738; HGNC ID: 11357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04630Jak-STAT signaling pathway
Pathway IDPathway Name
Signaling by EGFR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of STAM mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of STAM mRNAaffects expression 17562736
C103505 AM 251 AM 251 results in decreased expression of STAM mRNAdecreases expression 16500647
D001151 Arsenic Arsenic affects the expression of STAM mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STAM mRNAdecreases expression 19150397
D002330 Carmustine Carmustine results in decreased expression of STAM mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of STAM mRNAincreases expression 20106945
D004958 Estradiol Estradiol affects the expression of STAM mRNAaffects expression 14699072
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STAM mRNAaffects binding|increases activity|increases expression 19710929
C010327 salinomycin salinomycin results in decreased expression of STAM mRNAdecreases expression 19682730
D013752 Tetracycline Tetracycline results in increased expression of STAM mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D020261 Arsenic Poisoning Arsenic 2.9016251483 16835338 18414634 12569548
MESH:D050197 Atherosclerosis Arsenic 3.3312928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001932 Brain Neoplasms Carmustine 4.5216187019
MESH:D001943 Breast Neoplasms Estradiol 2.5316675129 17018787 19861407 14630087 17289903 18497071 17261762 12948864
MESH:D001943 Breast Neoplasms salinomycin 2.5319682730
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.733084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7316924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4318022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.807505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.8012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.8018566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.999022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.9919486331
MESH:D002779 Cholestasis pirinixic acid 13.9919176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9714531868 11906362 2524372 12868966 11298694 8156756 8970840 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.526482804 7440962 18648102 9328219 8291058 18692083 9653073 6679447 16192314 1440618 11289319 18289764 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5210915739 19085960 11743745 11834606 19416960 19370779 14550746 16081117 19739265 11421492 12594235 2444490 10774834 16393943 11287661 19923254 11739529 16781746 18071297 14986274 17906064 14725611 10663392 16109766 12540782 16227642 12153990 17562736 19420014 17522070 12392966 16177239 15619225 15968718 12705907 12958197 11529661 16485898 18713872 11461765 19164858
MESH:D056486 Drug-Induced Liver Injury Tetracycline 6.5217522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0719148513 18566989 11473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4920426865
MESH:D005234 Fatty Liver Cyclosporine 14.0019224547
MESH:D005234 Fatty Liver pirinixic acid 14.0020131406 19236843
MESH:D005234 Fatty Liver Tetracycline 14.0016917069 19224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Cyclosporine 3.3212168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Carmustine 4.0116187019
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Arsenic 5.469931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 5.4610903974
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007333 Insulin Resistance Estradiol 7.4916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 10.4215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.428314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.4215618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.066582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0612371664
MESH:D007680 Kidney Neoplasms Estradiol 13.0615610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 4.1711587558 19460945 12587719 16611625 19014921 12969438 19784758 16610002
MESH:D008107 Liver Diseases Arsenic 4.1711134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 4.7616368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.7615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.611399818 3712494 6587162 598648
MESH:D008175 Lung Neoplasms Arsenic 2.2017976673 19168569 17306315
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6817203775 16891317 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.6819682730
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008545 Melanoma Carmustine 2.8812393984
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009395 Nephritis, Interstitial Tetracycline 5.009884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.8116427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.676679447
MESH:D009436 Neural Tube Defects Arsenic 7.6716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms Arsenic 5.0817306315
MESH:D010051 Ovarian Neoplasms Estradiol 5.0819401270
MESH:D010146 Pain Acetaminophen 7.4916870215
MESH:D010146 Pain AM 251 7.4918987195
MESH:D010190 Pancreatic Neoplasms AM 251 3.8816500647
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6511026799
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1815371236 16905509 6392382
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D017096 Prion Diseases Tetracycline 5.6110903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Arsenic 3.3116140617
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012871 Skin Diseases Arsenic 2.786392382 15952646 16353154 17548696 19834688 17050553 18709164 17938729 16702368 17453740 16759981
MESH:D012878 Skin Neoplasms Arsenic 3.0715504454 17029826 17976673 17050553 19538983 16251483
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.997505956 6582329 3712494 1399818 6587162
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.378074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3715987713 17976673 19429237 17306315 18640142 11144890 19322015
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
KEGG:04630 Jak-STAT signaling pathway
REACT:11123 Membrane Trafficking
REACT:9417 Signaling by EGFR
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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