AutismKB 2.0

Annotation Detail for CDK5RAP3


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Basic Information Top
Gene Symbol:CDK5RAP3 ( C53,HSF-27,IC53,LZAP,MST016,OK/SW-cl.114 )
Gene Full Name: CDK5 regulatory subunit associated protein 3
Band: 17q21.32
Quick LinksEntrez ID:80279; OMIM: 608202; Uniprot ID:CK5P3_HUMAN; ENSEMBL ID: ENSG00000108465; HGNC ID: 18673
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D019386 Alendronate Alendronate affects the expression of CDK5RAP3 mRNAaffects expression 16079270
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CDK5RAP3 mRNAdecreases expression 20504355
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CDK5RAP3 mRNAaffects expression 16079270
D020849 Raloxifene Raloxifene affects the expression of CDK5RAP3 mRNAaffects expression 16079270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000419 Albuminuria Raloxifene 5.1017308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2120146248 17474063
MESH:D001943 Breast Neoplasms Raloxifene 2.2115758505 16837676 17893378 17049068 15775269 17440819 15572757 17242785 17952589 17595753 17261762 16912660
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1715861022 17333356 16105132 17110522 11677210 16919318 17681005
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3017308373 15920148 17451421
MESH:D004487 Edema Raloxifene 3.7615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.8512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.8515845917
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005234 Fatty Liver Ethinyl Estradiol 9.3115345470
MESH:D005234 Fatty Liver Raloxifene 9.3117473493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006930 Hyperalgesia Alendronate 5.0416769263
MESH:D006973 Hypertension Raloxifene 2.9815787275 17577099
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1521137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5718816296 20135361 18569708 18520028 20464547 20869020 20064080 6695378 17053015
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D010024 Osteoporosis Alendronate 8.5417882678
MESH:D010024 Osteoporosis Raloxifene 8.5419059307 15775268 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 17893378 15758505
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2216220300 15731164 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5219755658 10029692
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5917053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5917572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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