AutismKB 2.0

Annotation Detail for PLEKHO2


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Basic Information Top
Gene Symbol:PLEKHO2 ( DKFZp761K2312,FLJ38884,PLEKHQ1,PP1628,pp9099 )
Gene Full Name: pleckstrin homology domain containing, family O member 2
Band: 15q22.31
Quick LinksEntrez ID:80301; OMIM: NA; Uniprot ID:PKHO2_HUMAN; ENSEMBL ID: ENSG00000166839,ENSG00000241839; HGNC ID: 30026
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006253 pirinixic acid pirinixic acid results in increased expression of PLEKHO2 mRNAincreases expression 17426115
D014810 Vitamin E Vitamin E results in increased expression of PLEKHO2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.7218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.3716434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.7019483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.6916050911
MESH:D002779 Cholestasis pirinixic acid 3.1919176532
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.6118249437
MESH:C538011 Eales disease Vitamin E 5.779068938
MESH:D004487 Edema pirinixic acid 3.0212083418
MESH:D005234 Fatty Liver pirinixic acid 3.3119236843 20131406
MESH:D006330 Heart Defects, Congenital Vitamin E 3.2016080930
MESH:D006333 Heart Failure pirinixic acid 2.8120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.7616221962 18467677 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 5.0414716179
MESH:D006943 Hyperglycemia pirinixic acid 3.6920558911
MESH:D007251 Influenza, Human Vitamin E 5.2816624496
MESH:D007333 Insulin Resistance pirinixic acid 2.9316306350
MESH:D007674 Kidney Diseases Vitamin E 3.0512488133
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4915474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4916169303
MESH:D008113 Liver Neoplasms pirinixic acid 1.9516377806 20007298 15890375
MESH:D008171 Lung Diseases Vitamin E 3.4816863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D009135 Muscular Diseases pirinixic acid 4.2716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.3019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.3316411023
MESH:D009369 Neoplasms pirinixic acid 2.1417405874
MESH:D009765 Obesity pirinixic acid 1.9020558911
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2315084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5819058328
MESH:D012871 Skin Diseases Vitamin E 2.5318709164
MESH:D020521 Stroke Vitamin E 3.9316517955
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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