AutismKB 2.0

Annotation Detail for NCOA4


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Basic Information Top
Gene Symbol:NCOA4 ( ARA70,DKFZp762E1112,ELE1,PTC3,RFG )
Gene Full Name: nuclear receptor coactivator 4
Band: 10q11.22
Quick LinksEntrez ID:8031; OMIM: 601984; Uniprot ID:NCOA4_HUMAN; ENSEMBL ID: ENSG00000138293; HGNC ID: 7671
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05216Thyroid cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00032Thyroid cancer
Cancers of endocrine organs
No data
No data
No data
Desease Name
Thyroid carcinoma, papillary
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NCOA4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NCOA4 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NCOA4 mRNAincreases expression 18648102
C109238 acyline acyline results in decreased expression of NCOA4 mRNAdecreases expression 17510436
D013196 Dihydrotestosterone NCOA4 protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]increases activity|increases reaction 19815066
C006632 arsenic trioxide arsenic trioxide results in increased expression of NCOA4 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NCOA4 mRNAaffects expression 17331233
D016572 Cyclosporine Cyclosporine results in decreased expression of NCOA4 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of NCOA4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NCOA4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of NCOA4 mRNAaffects cotreatment|increases expression 17183730
C029938 nickel sulfate nickel sulfate results in decreased expression of NCOA4 mRNAdecreases expression 16780908
D011374 Progesterone Progesterone results in decreased expression of NCOA4 mRNAdecreases expression 18037150
D020849 Raloxifene Raloxifene affects the expression of NCOA4 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of NCOA4 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of NCOA4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NCOA4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NCOA4 mRNAincreases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of NCOA4 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9319490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D055371 Acute Lung Injury nickel sulfate 4.3119131640 16100012 11954676 12718980
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2919825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2914692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.753712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D000419 Albuminuria Raloxifene 4.6017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000550 Amblyopia Valproic Acid 5.2617688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5717497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0020603192 18985861 18775368 17157402 19460635 17507914 19232924 18316065 15238991 18558336 18940202 18177632 18396377 17688650 16609825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0511289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0817594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.9816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.0315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.038888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3717868700
MESH:D001930 Brain Injuries Progesterone 11.0115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 11.0116580743
MESH:D001943 Breast Neoplasms Progesterone 1.9615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 1.9617242785 15775269 17440819 15572757 17049068 17893378 17952589 16912660 16837676 15758505 17595753 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 1.9619066611 20135344 17049068 19189210 19244106 15565566 16818667 18855134 19487384 18629630 20859285 19103187 19221464 19155303 17440819 15668708 20005174 19059307 17893378 16273361 17261762 19084267 19288272 16202921 18425577 20544844 20390343 19142967 18821012 19115204 18997820 18351453 19011961 11161223 20065188 19189212 19289846 18984771 17242785 19410462 21138602 21152245 16873071 18815881 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3411589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.887296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8814691202 15553829 16217749 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8816924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.687296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1212490120
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.5117572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.5117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4515775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.156135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.157505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1512371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.4019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.4017333356 16105132 16919318 15861022 17681005 17110522 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1015340226 16354765 8697196 12621046 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6315800139
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.778888407 17688650 16575769
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.9418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1015213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1617474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.198156756 18759878 12868966 14531868 11906362 8970840 11298694 2524372
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.1916780908 16823706 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.503621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Raloxifene 9.0417451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.0419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5117187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.0318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.0318692083 9328219 16192314 9653073 8291058 6679447 18289764 18648102 6482804 1440618 7440962 11289319 9022650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.0320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.031733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004421 Dystonia Valproic Acid 4.061851702
MESH:D004487 Edema Raloxifene 6.8715860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 22.0312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 22.0317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 22.0315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 22.0319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0519155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Progesterone 8.9416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.949294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.173659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.953922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.596426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.317750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.083659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver arsenic trioxide 30.8415073043
MESH:D005234 Fatty Liver Cyclosporine 30.8419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.8415345470
MESH:D005234 Fatty Liver Raloxifene 30.8417473493
MESH:D005234 Fatty Liver Tamoxifen 30.8419224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 30.8414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1418558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.056705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2019069698
MESH:D005355 Fibrosis Cyclosporine 8.5312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.5320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2716904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.047505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5411110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.526705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D006849 Hydrocephalus Valproic Acid 4.8917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.088697196 15340226 16959395 18606429 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9515034207
MESH:D006973 Hypertension Cyclosporine 8.5910903974
MESH:D006973 Hypertension Raloxifene 8.5917577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5918850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.6416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Progesterone 8.3115869954
MESH:D007249 Inflammation Tamoxifen 8.3119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3112200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.058074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 23.3716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 23.376582329
MESH:D007680 Kidney Neoplasms Cyclosporine 23.3712371664
MESH:D007680 Kidney Neoplasms Tamoxifen 23.3718625569
MESH:D007889 Leiomyoma Raloxifene 4.5016973256
MESH:D007938 Leukemia arsenic trioxide 2.8315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9116467208 16968895 19850784 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9117596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2216891316 12018890 15213294 17869043 15336539 11161223 16112521 16823087 19075265 19225113 19035177 12679006 17712046 16966277 11468182 17217047 17107899 16330433 16331271 15622746 12712474 17649720 15748426 19642359 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3616882451
MESH:D008064 Lipidoses Tamoxifen 3.1617567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.2818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2812878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.707678174
MESH:D008113 Liver Neoplasms arsenic trioxide 10.7014682389
MESH:D008113 Liver Neoplasms Tamoxifen 10.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.122876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.12598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.1220377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.1212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3515213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2917228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0417365036
MESH:D008175 Lung Neoplasms arsenic trioxide 3.3811798837 19825857
MESH:D008175 Lung Neoplasms Tamoxifen 3.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3819555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7819428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.0911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.0914580682 11731420 19196723 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1816166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1918803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5815863610
MESH:D009101 Multiple Myeloma arsenic trioxide 7.4214977855 19417148 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma Raloxifene 7.4216497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.038888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.4216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D009232 Myxoma Raloxifene 5.5816343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.4118551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9716624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.703581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319196722 19200415 19189210
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.156679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.1510525206
MESH:D009436 Neural Tube Defects Valproic Acid 12.1516359493 8888407
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.0916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.096482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.053988306
MESH:D010024 Osteoporosis Raloxifene 3.3915775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2317893378 17823083 15758505 15579764
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9412452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Progesterone 4.9417393432 16525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5215580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.507296757
MESH:D010235 Paraganglioma arsenic trioxide 4.1719927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.506228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5311896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.5320603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6219131511
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6216220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6215067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.5711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0317322281 17975199 17365031 15814490
MESH:D011693 Purpura Raloxifene 5.5815770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.383692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1819155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9716646077
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures 2,4-dinitrotoluene 9.8318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.8318551238
MESH:D012640 Seizures Valproic Acid 9.831511512 15475178 3137016 16876388 11044598 14763951 17978042 11738929
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.9415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.9419457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5712833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Raloxifene 3.8216837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
OMIM:188550 THYROID CARCINOMA, PAPILLARY marker/mechanism
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.166582329 3712494 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.1619014326
MESH:D013978 Tibial Fractures Raloxifene 5.2419048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9815213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.2617262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.543119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 19.9116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 19.9116049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 19.918074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 19.9111780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 19.9117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.9117572228 16712894 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.668888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.0610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.0610091137
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:05200 Pathways in cancer
KEGG:05216 Thyroid cancer
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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