AutismKB 2.0

Annotation Detail for PDGFD


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Basic Information Top
Gene Symbol:PDGFD ( IEGF,MGC26867,SCDGF-B,SCDGFB )
Gene Full Name: platelet derived growth factor D
Band: 11q22.3
Quick LinksEntrez ID:80310; OMIM: 609673; Uniprot ID:PDGFD_HUMAN; ENSEMBL ID: ENSG00000170962; HGNC ID: 30620
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05215Prostate cancer
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by PDGF
No data
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1848Embryoma
1918Atherosclerosis
2106Pancreas cancer
2174Chronic rejection of renal transplant
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of PDGFD mRNAincreases expression 20406850
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDGFD mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of PDGFD mRNAdecreases expression 20106945
D019808 Losartan Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]decreases reaction|increases expression 17043664
C009250 sevoflurane sevoflurane affects the expression of PDGFD mRNAaffects expression 15967596
D014415 Tunicamycin Tunicamycin results in increased expression of PDGFD mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000419 Albuminuria Losartan 6.2212586211
MESH:D050197 Atherosclerosis Losartan 4.6610821809
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016097048 16227642 16124888 3786805 18705752 15673190 16192424 10355542 15721981 16011737 15700767 16050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1018788625
MESH:D006332 Cardiomegaly Losartan 4.7315969258 12586211
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.276135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2712371664
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003324 Coronary Artery Disease marker/mechanism 21378988
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.4418551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1319336974 2869522 7179309 16177239 10092053 16227642 7120509 7440962 6884620 21278145 9327722 19085960 3786805 15968718 15027814 10915739 3732212 4309450 11566570 15998439 6623471 17522070
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.8115959796 17595544 12631006 19224547 16045604 16239168 12795759 61145
MESH:D005234 Fatty Liver Cyclosporine 8.8119224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0918705752
MESH:D005355 Fibrosis Cyclosporine 10.0912168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006333 Heart Failure Losartan 4.8210979640
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Cyclosporine 6.0910903974
MESH:D006973 Hypertension Losartan 6.0912512695 12586211 14597852 15969258 10090350
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Losartan 4.2012586211
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.508314463 18776723 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.1816705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.1812371664
MESH:D007859 Learning Disorders sevoflurane 5.1919212262
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9616943688 21278145 11408273 16221502 17157831 11903743 16239168 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.1718166357 18418968 18339082 17805973 17976157 17922224 18205269 17714472 15925388 16015684 12389079 18472094 16116963 17869086 15650968 18210741 16033810 16248980 14716496 18472332 15123356 17525996 13678700 15931870 17900296 12445421 12741479 18187930 17944888 18251166 15057751 14748882 17721639 18412020 16097048 17631135 15996030 12667390 10355542 12898905 14512876 15673190 18279442 17761835 18705752 15876570 12666154 12546737 18054572 16136751 15893842 17557913 11481614 18395914 18429990 16192424 16027843 17766677 18006644 17481882 15959796 12632512 14716833 16638106 18263696 15730626 17698563 15818738 15370692 17708605 12586293 17640975 18481824 12445418 18317297 12958196 17565644 18277467 14620537 15338365 18395095 12649538 12609069 18156304 14724832 18376398 18420326 12632514 15362042 16011737 17823541 15052691 20821823
MESH:D008106 Liver Cirrhosis, Experimental Losartan 3.1712445418 15573910 17900296
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416964402 15830285 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.897678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8919294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.532876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5312014681 15583823
MESH:D008382 Marfan Syndrome Losartan 6.4919430350
MESH:D008569 Memory Disorders sevoflurane 5.1319212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009203 Myocardial Infarction Losartan 4.3512692751
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.3218551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5718481113 19348381
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7416049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D051437 Renal Insufficiency Losartan 5.9415728788
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7418551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7810091137
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05218 Melanoma
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
REACT:16888 Signaling by PDGF
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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