AutismKB 2.0

Annotation Detail for TET1


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Basic Information Top
Gene Symbol:TET1 ( CXXC6,FLJ10839,FLJ41442,KIAA1676,LCX,bA119F7.1 )
Gene Full Name: tet oncogene 1
Band: 10q21.3
Quick LinksEntrez ID:80312; OMIM: 607790; Uniprot ID:TET1_HUMAN; ENSEMBL ID: ENSG00000138336; HGNC ID: 29484
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TET1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TET1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of TET1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TET1 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of TET1 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.003084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.001917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002386 Cataract Tretinoin 7.8517460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1815340226 8697196 12621046 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 6.189407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.5316925845 8800419 9224671 10589399 9211117 14991402 9142499 17551590 9664655 9125849
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8316081117 19164858 16177239 14725611 16109766 2444490 15968718 19416960 19085960 19923254 14986274 12392966 16227642 18071297 17522070 11287661 11834606 11529661 15619225 11743745 19420014 16485898 11421492 11461765 10774834 16781746 12958197 19739265 17562736 18713872 10915739 19370779 14550746 17906064 12594235 12540782 12153990 11739529 16393943 12705907 10663392
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 14.0718230668 16714409 15322242
MESH:D004489 Edema, Cardiac Tretinoin 14.0718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.379294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.7111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.7116938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 17.7412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.7420067830
MESH:D005355 Fibrosis Tretinoin 17.7417994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 12.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 12.0510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 12.0514991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3712621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.6016870215
MESH:D006930 Hyperalgesia Tretinoin 8.6016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.418314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3719642359 16331271 9834237 17649720 16140955 17368321 17712046 17294898 17107899 16766008 19035177 16891316 17339181 19029980 16935935 17361223 17217047 19225113 17301526 16788101 19075265 16823087 12679006 15748426 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3918397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 12969438 11587558 16611625 19460945 12587719 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7020195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2620464547 20135361 17053015 6695378 18816296 18520028 20064080 18569708 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2619555203 11884234
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5011141357
MESH:D009369 Neoplasms Tretinoin 5.5016594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 11.029125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Acetaminophen 7.6116870215
MESH:D010146 Pain Tretinoin 7.6116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.2310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 10.2316467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.412093021 20155912
MESH:D013274 Stomach Neoplasms Tretinoin 2.4117261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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