AutismKB 2.0

Annotation Detail for EPC1


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Basic Information Top
Gene Symbol:EPC1 ( DKFZp781P2312,Epl1 )
Gene Full Name: enhancer of polycomb homolog 1 (Drosophila)
Band: 10p11.22
Quick LinksEntrez ID:80314; OMIM: 610999; Uniprot ID:EPC1_HUMAN; ENSEMBL ID: ENSG00000120616; HGNC ID: 19876
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EPC1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of EPC1 mRNAincreases expression 19774075
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of EPC1 mRNAincreases expression 18687144
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of EPC1 mRNAdecreases expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EPC1 mRNAaffects expression 17555576
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of EPC1 mRNAaffects cotreatment|increases expression 17183730
D014284 Triiodothyronine Triiodothyronine results in increased expression of EPC1 mRNAincreases expression 17403546
D013974 Thyroxine Thyroxine affects the expression of EPC1 mRNAaffects expression 17403546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of EPC1 mRNAaffects expression 16611356
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of EPC1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.118875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9620041841 18218290 18057881
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8617507914 18985861 20603192 18558336 18316065 18940202 15238991 18396377 18177632 19460635 19232924 17688650 17157402 18775368 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.6219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.3715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.378888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9916192424 16227642 16050911 15673190 15700767 18705752 15721981 16011737 16097048 3786805 10355542 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9118788625
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3818850075 18670907 16120746
MESH:D006332 Cardiomegaly Thyroxine 7.3818093424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017333356 16105132 15861022 16919318 11677210 17681005 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 12621046 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.528888407 16575769 17688650
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5114725611 11739529 19416960 2444490 19739265 12594235 16781746 19370779 11461765 12540782 16177239 14986274 11421492 17562736 15968718 16485898 19085960 10663392 17906064 11743745 16109766 19420014 11287661 16227642 17522070 11529661 18071297 19923254 10915739 18713872 16081117 12153990 12958197 11834606 12705907 14550746 19164858 10774834 15619225 12392966 16393943
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.5118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.5119085960 6623471 17522070 10915739 4309450 6884620 16177239 3786805 2869522 7179309 7440962 15027814 16227642 3732212 15968718 15998439 9327722 21278145 7120509 10092053 19336974 11566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 12.511733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Amiodarone 20.2814986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2816045604 12631006 19224547 16239168 61145 15959796 12795759 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2815345470
MESH:D005234 Fatty Liver Valproic Acid 20.2814986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919900420 19110552
MESH:D006529 Hepatomegaly Amiodarone 9.2715265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.2716120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006937 Hypercholesterolemia Amiodarone 4.048137927 9751232
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.7318020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008064 Lipidoses Amiodarone 3.6315342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8917157831 17334410 16221502 17174718 21278145 16943688 16239168 11408273 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3315996030 17976157 12958196 12649538 15893842 14716496 10355542 12898905 15650968 17714472 12586293 18472094 18429990 15370692 16097048 17922224 14724832 17557913 20821823 14620537 18279442 18472332 15123356 15931870 11481614 14512876 15052691 12632514 18339082 17823541 12741479 17481882 15362042 17698563 18166357 16011737 18481824 18054572 18205269 14716833 16033810 18395095 17721639 15673190 17900296 18251166 16116963 17869086 18705752 18376398 15057751 12546737 18317297 16015684 17944888 12445418 16027843 17708605 17565644 12389079 16192424 16136751 17805973 17761835 17525996 12609069 15876570 14748882 18210741 15730626 12632512 18263696 13678700 16638106 12445421 15925388 17766677 12666154 18156304 15818738 16248980 18420326 15338365 18006644 18187930 18277467 18418968 15959796 12667390 17631135 18412020 18395914 17640975
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319014921 12969438 19460945 16611625 11587558 16610002 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316246199 15720792 17285989 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.5919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7117391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 12.1718516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.1717228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2417365036
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2418303189 16166281 16966607
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009181 Mycoses Amiodarone 5.1712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.238888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2711118676 11896295 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.2720603192
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.0812490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 6.0817322281 17365031 17975199 15814490
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8516876388 14763951 17978042 11044598 15475178 3137016 11738929 1511512
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Amiodarone 22.7619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 22.7612697716
MESH:D013959 Thyroid Diseases Thyroxine 22.7619910387
MESH:D013971 Thyrotoxicosis Amiodarone 5.0818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.4311989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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