AutismKB 2.0

Annotation Detail for ZKSCAN3


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Basic Information Top
Gene Symbol:ZKSCAN3 ( FLJ33906,KIAA0426,ZF47,ZFP306,ZNF306,ZNF309,ZSCAN13,Zfp47,dJ874C20.1 )
Gene Full Name: zinc finger with KRAB and SCAN domains 3
Band: 6p22.1
Quick LinksEntrez ID:80317; OMIM: 612791; Uniprot ID:ZKSC3_HUMAN; ENSEMBL ID: ENSG00000189298; HGNC ID: 13853
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ZKSCAN3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ZKSCAN3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ZKSCAN3 mRNAaffects expression 17562736
D005472 Fluorouracil ZKSCAN3 protein results in decreased susceptibility to Fluorouracildecreases response to substance 18519692
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of ZKSCAN3 mRNAincreases expression 16330358
C025643 vinclozolin vinclozolin results in decreased expression of ZKSCAN3 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D000740 Anemia Fluorouracil 4.0217963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Fluorouracil 2.4419217205 18357371 15136595 16595493 18608205 16110121 16557594
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.8917971768 16332177 17088986 17045692 16799960 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5616280240 18986760 17066447 16757204
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.986135515
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717287894 18772588 17018589 17725105 16510598 17169374 16340194 17016597 15001691 17172411
MESH:D015179 Colorectal Neoplasms marker/mechanism 18519692
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018383874 18448328 18509181 16282729 16303861 14970324 15148649 17594712 17454858 17401013 15289873 20501625 16331619 16391804 17094418 18802399 18288408 16524972 17695437 17016601 18949393 17255274
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.6416684804
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6219085960 14725611 12958197 14986274 19420014 11529661 12392966 19416960 16485898 19739265 19923254 11461765 16227642 18071297 17562736 11739529 2444490 10663392 19370779 10915739 15619225 12594235 16177239 15968718 16393943 14550746 10774834 11743745 16081117 17906064 16109766 12540782 18713872 19164858 11421492 17522070 12705907 12153990 11287661 11834606 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5116785472 15173087 16337965 16481741 17638652
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915162350 18337622 15102660
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 14.0516985049
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008107 Liver Diseases Acetaminophen 1.6916611625 11587558 19784758 12587719 16610002 19014921 12969438 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.987678174
MESH:D008113 Liver Neoplasms Fluorouracil 4.9818383874 15113037 17045692 16603448
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 2876786 6135515
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009369 Neoplasms Fluorouracil 2.7418239605 18600527 16928823
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 19003803 16929163 16500647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3618626508 19082440
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 18722050 18286688 16160472
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 18567086 16424979 19015929 15786421 18396642 19084572 17498489 17172411 16951190
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
Pathway ID Pathway Name
REACT:71 Gene Expression
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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