Annotation Detail for CXXC4
Basic Information
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| Pathway ID | Pathway Name |
|---|
| hsa04310 | Wnt signaling pathway |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of CXXC4 mRNA | affects expression | 16483693
|
| D018817 |
N-Methyl-3,4-methylenedioxyamphetamine |
N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CXXC4 mRNA | increases expression | 19285098
|
| D010656 |
Phenylephrine |
Phenylephrine results in decreased expression of CXXC4 mRNA | decreases expression | 18158353
|
| D012402 |
Rotenone |
Rotenone results in decreased expression of CXXC4 mRNA | decreases expression | 19013527
|
| D014635 |
Valproic Acid |
Valproic Acid results in increased expression of CXXC4 mRNA | increases expression | 19101580
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.02 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.30 | 19490988 |
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.10 | 18287403 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
5.85 | 17688650 |
| MESH:D000855 |
Anorexia |
|
N-Methyl-3,4-methylenedioxyamphetamine |
5.67 | 15146954 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.86 | 17497229 |
| MESH:D001145 |
Arrhythmias, Cardiac |
|
Phenylephrine |
4.46 | 17460149 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 18985861 18177632 18316065 19232924 15238991 18396377 18558336 17507914 20603192 17688650 18775368 18940202 16609825 19460635 17157402 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.23 | 20046352 17594078 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.61 | 8888407 |
| MESH:D001919 |
Bradycardia |
|
Phenylephrine |
5.08 | 15306635 |
| MESH:D006332 |
Cardiomegaly |
|
Phenylephrine |
3.70 | 16170337 15728586 11179087 17124262 17287366 11754973 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.81 | 20734317 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.90 | 16575769 8888407 17688650 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.25 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.45 | 1851702 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.64 | 17275665 3659116 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.53 | 3922381 16628512 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.09 | 20417680 18234410 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
3.91 | 6254150 7562514 6426943 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.78 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.60 | 3659116 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
3.67 | 14986274 19224547 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.50 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.57 | 8888407 18558336 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.41 | 17688650 |
| MESH:D006973 |
Hypertension |
|
Phenylephrine |
3.18 | 12717712 8949925 |
| MESH:D006984 |
Hypertrophy |
|
Phenylephrine |
4.93 | 18502941 12791704 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.19 | 17596541 16294345 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
4.87 | 17228818 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.44 | 18765137 18803445 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.40 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.33 | 17596541 |
| MESH:D009410 |
Nerve Degeneration |
|
Rotenone |
4.15 | 17356569 15790535 18619942 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.34 | 8888407 16359493 |
| MESH:D010300 |
Parkinson Disease |
|
Rotenone |
3.08 | 16412576 11445065 19232380 19114014 16140633 11535288 18191903 15451049 18619942 |
| MESH:D020734 |
Parkinsonian Disorders |
|
Rotenone |
4.42 | 15574749 18197244 15927086 15795934 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.37 | 20603192 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.15 | 12752131 11422049 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.58 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.10 | 19110320 15737665 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
2.96 | 3137016 17978042 11044598 11738929 1511512 15475178 14763951 16876388 |
| MESH:D012852 |
Sinusitis |
|
Phenylephrine |
5.24 | 7327846 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.06 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.15 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
5.85 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.06 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.13 | 8888407 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:04310 |
Wnt signaling pathway |
Related Diseases/Disorders