AutismKB 2.0

Annotation Detail for CCDC68


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Basic Information Top
Gene Symbol:CCDC68 ( FLJ25368,SE57-1 )
Gene Full Name: coiled-coil domain containing 68
Band: 18q21.2
Quick LinksEntrez ID:80323; OMIM: NA; Uniprot ID:CCD68_HUMAN; ENSEMBL ID: ENSG00000166510; HGNC ID: 24350
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of CCDC68 proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of CCDC68 mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of CCDC68 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CCDC68 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCDC68 mRNAincreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of CCDC68 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CCDC68 mRNAdecreases expression 17557909
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCDC68 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D020261 Arsenic Poisoning Arsenic 2.9212569548 16835338 18414634 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.3212619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.3217306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.9115504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9120419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D002779 Cholestasis Cyclosporine 14.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.3816105132 17110522 16919318 17333356 15861022 11677210 17681005
MESH:D002779 Cholestasis pirinixic acid 14.3819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver Cyclosporine 14.4619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.4615345470
MESH:D005234 Fatty Liver pirinixic acid 14.4620131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19772884 16221962 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 5.5616076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.5610903974
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007642 Keratosis Arsenic 5.3312749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 2.4610903974 8314463 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.372125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Arsenic 11.3716368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.3721137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 11.3720007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6114755239
MESH:D008175 Lung Neoplasms Arsenic 3.6117976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.616695378 17053015 20135361 18520028 20869020 20464547 20064080 18816296 18569708
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2618303189 16966607 16166281
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects Arsenic 3.6016620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.336392382 16905509 15371236
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011471 Prostatic Neoplasms Arsenic 3.2516140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1015814490 17365031 17322281 17975199
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012871 Skin Diseases Arsenic 2.8016702368 18709164 16759981 19834688 17453740 17548696 6392382 17050553 15952646 17938729 16353154
MESH:D012878 Skin Neoplasms Arsenic 6.1617976673 19538983 17029826 15504454 16251483 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.1610029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4419322015 17306315 11144890 18640142 17976673 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4417053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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