AutismKB 2.0

Annotation Detail for DNAJC5


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Basic Information Top
Gene Symbol:DNAJC5 ( CSP,DKFZp434N1429,DKFZp761N1221,DNAJC5A,FLJ00118,FLJ13070 )
Gene Full Name: DnaJ (Hsp40) homolog, subfamily C, member 5
Band: 20q13.33
Quick LinksEntrez ID:80331; OMIM: 611203; Uniprot ID:DNJC5_HUMAN; ENSEMBL ID: ENSG00000101152; HGNC ID: 16235
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
Pathway IDPathway Name
Synaptic Transmission
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of DNAJC5 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DNAJC5 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DNAJC5 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DNAJC5 mRNAdecreases expression 19150397
D007099 Imipramine Imipramine results in increased expression of DNAJC5 mRNAincreases expression 11257428
D007099 Imipramine Imipramine results in increased expression of DNAJC5 proteinincreases expression 11257428
D001556 Lindane Lindane results in decreased expression of DNAJC5 mRNAdecreases expression 17785943
D020280 Sertraline Sertraline results in increased expression of DNAJC5 mRNAincreases expression 11257428
D020280 Sertraline Sertraline results in increased expression of DNAJC5 proteinincreases expression 11257428
D024505 Tocopherols Tocopherols results in increased expression of DNAJC5 mRNAincreases expression 17654050
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D000382 Agricultural Workers' Diseases Lindane 4.7012661182
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Sertraline 5.2918822694
MESH:D001321 Autistic Disorder Acetaminophen 2.4218445737
MESH:D001321 Autistic Disorder Sertraline 2.4218775368
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001943 Breast Neoplasms Lindane 3.2014688026
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.913581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.187505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3219486331 9022650
MESH:D003866 Depressive Disorder Imipramine 9.4220305041
MESH:D003866 Depressive Disorder Sertraline 9.4215014590 18822694 20305041
MESH:D003865 Depressive Disorder, Major Sertraline 5.5816968574
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108970840 11906362 18759878 12868966 14531868 8156756 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9118692083 9022650 18289764 7440962 6679447 9328219 11289319 8291058 6482804 18648102 9653073 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9116485898 16227642 16393943 11834606 16081117 19416960 16177239 18071297 19085960 11461765 16109766 19739265 19370779 14986274 12392966 12705907 12958197 11287661 17562736 15968718 11529661 11421492 19923254 16781746 11739529 17522070 12153990 14725611 10915739 14550746 19164858 17906064 11743745 2444490 15619225 19420014 10663392 10774834 12540782 12594235 18713872
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema Imipramine 4.7812798668
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5620426865
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006816 Huntington Disease Sertraline 6.3318403212
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007249 Inflammation Imipramine 4.1312798668
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D008064 Lipidoses Imipramine 9.5717567588 15342952
MESH:D008064 Lipidoses Sertraline 9.5717567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 4.4419014921 16611625 12969438 12587719 19460945 19784758 11587558 16610002
MESH:D008107 Liver Diseases Lindane 4.441715830
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.67598648 6587162 3712494 1399818
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.2217927505
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D001523 Mental Disorders Imipramine 10.1116856516
MESH:D001523 Mental Disorders Sertraline 10.1116856516
MESH:D008654 Mesothelioma Tocopherols 4.1915878867
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms Lindane 3.4712807735 16818664
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 7.8516870215
MESH:D010146 Pain Imipramine 7.8512798668
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011471 Prostatic Neoplasms Lindane 4.0512661182 14688026
MESH:D011471 Prostatic Neoplasms Tocopherols 4.0512504091
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012640 Seizures Lindane 3.777539098 12842176 15475178
MESH:D012892 Sleep Deprivation Imipramine 6.5319798453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.061399818 6582329 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
REACT:13685 Synaptic Transmission
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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