AutismKB 2.0

Annotation Detail for DCAF11


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Basic Information Top
Gene Symbol:DCAF11 ( DKFZp779A1629,PRO2389,WDR23 )
Gene Full Name: DDB1 and CUL4 associated factor 11
Band: 14q12
Quick LinksEntrez ID:80344; OMIM: 613317; Uniprot ID:DCA11_HUMAN; ENSEMBL ID: ENSG00000100897; HGNC ID: 20258
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DCAF11 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DCAF11 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of DCAF11 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of DCAF11 mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of DCAF11 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of DCAF11 mRNAdecreases expression 20106945
D005001 Ethionine Ethionine affects the expression of DCAF11 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of DCAF11 mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DCAF11 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of DCAF11 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid affects the expression of DCAF11 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of DCAF11 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of DCAF11 mRNAaffects binding|decreases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DCAF11 mRNAdecreases expression 18796159
D013853 Thioacetamide Thioacetamide affects the expression of DCAF11 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9018057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 3.9818651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 61.3519483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 61.3519483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 61.3519483382
MESH:D001778 Blood Coagulation Disorders Ethionine 61.3519483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 61.3519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 61.3519483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 61.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 61.3512125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 61.3519483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7712907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.771701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.7717997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2418974383
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 7.101399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1012371664
MESH:D002637 Chest Pain Omeprazole 5.2815447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.8816835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.8818291259
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2510915739 10663392 16781746 18713872 19085960 19416960 15968718 11739529 11421492 19164858 14725611 16393943 17522070 18071297 17906064 10774834 12705907 16485898 16177239 19370779 19739265 17562736 11287661 12540782 2444490 11529661 15619225 12594235 14986274 11743745 19420014 12153990 16081117 11461765 11834606 14550746 19923254 12392966 12958197 16227642 16109766
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.2515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 9.2512963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.4517151854 21218061 15991576 16613094
MESH:D050171 Dyslipidemias Clofibrate 4.1416707586
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8916456712
MESH:D005234 Fatty Liver Amiodarone 19.7514986274
MESH:D005234 Fatty Liver Clofibrate 19.7519224547
MESH:D005234 Fatty Liver Cyclosporine 19.7519224547
MESH:D005234 Fatty Liver pirinixic acid 19.7519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6818665440 15929193 17276928
MESH:D006505 Hepatitis Thioacetamide 4.3416456712
MESH:D006529 Hepatomegaly Amiodarone 15.2615265979
MESH:D006529 Hepatomegaly pirinixic acid 15.2618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2615340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 18606429 8697196 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.989751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 12.0818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 12.088137927 18031379
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.998314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1919248655
MESH:D008064 Lipidoses Amiodarone 3.5915342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5310677585 17050028 18263696 17629604 15288473 18295389 15075984 12531686 17127702 18395095 15465738 15095483 16098781 16343077 18416461 16126171 14739098 11172339 11481614 15288472 12679928 16511523 15334695 16097051 15362042 18032466 12175628 11682029 16248980 17355460 12557150 18031379 12891558 15078482 18458672 18615449 18380797 18606216 15316131 12085344 15158331 15474484 17292413 16489207 15716488
MESH:D008107 Liver Diseases Acetaminophen 4.2119460945 11587558 19784758 19014921 12969438 16610002 16611625 12587719
MESH:D008107 Liver Diseases Thioacetamide 4.2118374380 15158337 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.9815633222 15313186 17276928 12479984
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.572125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 7.5716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.038603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3214755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009181 Mycoses Amiodarone 5.0817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.089802331
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8912832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2418724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013272 Stomach Diseases Omeprazole 4.7618545984
MESH:D013276 Stomach Ulcer Amiodarone 7.9418087811
MESH:D013276 Stomach Ulcer Omeprazole 7.9415991576 17977527 16755016 18237397 10750652 11906479
MESH:D013610 Tachycardia Amiodarone 4.4211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3219225199
MESH:D013959 Thyroid Diseases Amiodarone 12.6419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.6412697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7615710170
MESH:D013971 Thyrotoxicosis Amiodarone 5.0018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3417467628 11989578
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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