AutismKB 2.0

Annotation Detail for TSGA10


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Basic Information Top
Gene Symbol:TSGA10 ( CEP4L,CT79 )
Gene Full Name: testis specific, 10
Band: 2q11.2
Quick LinksEntrez ID:80705; OMIM: 607166; Uniprot ID:TSG10_HUMAN; ENSEMBL ID: ENSG00000135951; HGNC ID: 14927
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1831Prostate cancer
2022Liver cancer
2051Leukemia
2053Colon cancer
2125Bladder cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of TSGA10 mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of TSGA10 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TSGA10 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of TSGA10 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of TSGA10 mRNAdecreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TSGA10 mRNA]decreases expression|decreases reaction 17942915
D008345 Manganese Manganese results in increased expression of TSGA10 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of TSGA10 mRNAincreases expression 17175027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.163712494
MESH:D000236 Adenoma Diethylnitrosamine 7.1610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3019052882 17162532 16434500 19061943 17620307 18056438
MESH:D000756 Anemia, Sideroblastic Manganese 11.9916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.9916910769
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.1119698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.1819483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.097296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.0910737359 3084413 18978308 19701751 20727157 19822196 18494052 20935162 18665156 19208518 20432363 16502159 16878318 19919837 20514400 17761372 20101231 16807293 18691550 17055752 18788625 20007298 16540662 10672840 18971187 17428255 20512989 19539802 16830150 18393292 16681979 17173139 19418558 21159647 19383236 11831363 16698587 16779866 19107877 19052882 17162532 18506893 18056438 16288022 16935385 16328049 17138121 20214788 19519916 19335982 18785209 18210153 3581430 17978847 16569478 19171122 20524982 19394651 20084675
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9719225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.247505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.2412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.2421159647 17174075 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.569022650 19486331
MESH:D002779 Cholestasis Cyclosporine 8.5619486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.158970840 12868966 11298694 11906362 18759878 14531868 8156756 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.7018289764 1440618 9022650 9328219 18648102 7440962 18692083 6679447 8291058 16192314 6482804 9653073 11289319
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.7018218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.7019107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D005234 Fatty Liver Amiodarone 14.8514986274
MESH:D005234 Fatty Liver Cyclosporine 14.8519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.8521071580 20387270
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005355 Fibrosis Cyclosporine 3.5012168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Manganese 4.0817043766
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006529 Hepatomegaly Amiodarone 4.1115265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007037 Hypothyroidism Amiodarone 4.8718020914 17991464
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.469022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.066582329
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008064 Lipidoses Amiodarone 3.7015342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9620032147 19638242 18407596 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3515034207 9327722
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3220583210 19499222 19551842 19812893 2862719 9163691 20434301 20137499 21167192 19690152 19294768 12112319 20501860 19254457 19996281 16942905 15885732 21278145 18978307 19426721 19090486 21047994 19850985 20452335 20118626 18648771 21071580 20492335 2422723 18977376 19255062 19638242 19642983 12771043 18754104 19256749 19427195 19073162 20405173 19833225 10737359 18644402 15175105 20101389
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.46598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4619004024 18164116 18282651 18544905 19539802 17942915 18308698 18093689 17174075 16842330 2563599 19126423 19519916 3124819 19009564 18079962 17854601 18253720 21159647 18775883 9362446 16267830
MESH:D008133 Long QT Syndrome Amiodarone 3.7917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D020149 Manganese Poisoning Manganese 5.9616551646 16568477 19453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009069 Movement Disorders Manganese 5.3116551646
MESH:D009181 Mycoses Amiodarone 5.3412754197 17974566
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.013581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.013581430 9029167
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.4816551646
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.686482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010300 Parkinson Disease Manganese 3.4511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.7316140633
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011230 Precancerous Conditions Cyclosporine 9.7912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.792563599
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412832656 12490602 11597910
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2019731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.831399818 7505956 3712494 6582329 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.837505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.2218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5911989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.368074119
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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