Annotation Detail for AKNA
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D016572 |
Cyclosporine |
Cyclosporine results in increased expression of AKNA mRNA | increases expression | 20106945
|
| D013749 |
Tetrachlorodibenzodioxin |
Tetrachlorodibenzodioxin results in increased expression of AKNA mRNA | increases expression | 19465110
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Tetrachlorodibenzodioxin |
3.73 | 15322242 11752688 14514962 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
Tetrachlorodibenzodioxin |
4.26 | 16835633 |
| MESH:D000740 |
Anemia |
|
Tetrachlorodibenzodioxin |
3.45 | 11748828 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
Tetrachlorodibenzodioxin |
3.59 | 12125929 |
| MESH:D001836 |
Body Weight Changes |
|
Tetrachlorodibenzodioxin |
4.86 | 15340226 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Tetrachlorodibenzodioxin |
3.05 | 15746008 |
| MESH:D001943 |
Breast Neoplasms |
|
Tetrachlorodibenzodioxin |
1.66 | 20435547 |
| MESH:D002277 |
Carcinoma |
|
Tetrachlorodibenzodioxin |
3.21 | 16835633 |
| MESH:D006332 |
Cardiomegaly |
|
Tetrachlorodibenzodioxin |
2.60 | 18850075 16120746 18670907 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
Cyclosporine |
2.85 | 12371664 |
| MESH:D018281 |
Cholangiocarcinoma |
|
Tetrachlorodibenzodioxin |
3.63 | 16835633 |
| MESH:D002779 |
Cholestasis |
|
Cyclosporine |
3.28 | 19486331 |
| MESH:D002972 |
Cleft Palate |
|
Tetrachlorodibenzodioxin |
2.26 | 16354765 12621046 8697196 15340226 15668235 |
| MESH:D000013 |
Congenital Abnormalities |
|
Tetrachlorodibenzodioxin |
3.53 | 14669216 17141729 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Tetrachlorodibenzodioxin |
1.27 | 10048152 15322242 20055451 |
| MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Tetrachlorodibenzodioxin |
1.75 | 17107852 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Tetrachlorodibenzodioxin |
1.63 | 20420201 |
| MESH:D004362 |
Drug Toxicity |
|
Tetrachlorodibenzodioxin |
3.12 | 11462148 |
| MESH:D004487 |
Edema |
|
Tetrachlorodibenzodioxin |
2.92 | 11000095 12711302 |
| MESH:D004489 |
Edema, Cardiac |
|
Tetrachlorodibenzodioxin |
4.97 | 18230668 15322242 16714409 |
| MESH:D004715 |
Endometriosis |
|
Tetrachlorodibenzodioxin |
3.53 | 9294722 10568697 |
| MESH:D005124 |
Eye Abnormalities |
|
Tetrachlorodibenzodioxin |
3.38 | 11564622 |
| MESH:D005234 |
Fatty Liver |
|
Cyclosporine |
3.40 | 19224547 |
| MESH:D005313 |
Fetal Death |
|
Tetrachlorodibenzodioxin |
4.22 | 11858732 |
| MESH:D005355 |
Fibrosis |
|
Cyclosporine |
11.16 | 12639820 12168785 |
| MESH:D005355 |
Fibrosis |
|
Tetrachlorodibenzodioxin |
11.16 | 20067830 |
| MESH:D005885 |
Gingival Hyperplasia |
|
Cyclosporine |
5.11 | 8708960 |
| MESH:D006058 |
Gonadal Disorders |
|
Tetrachlorodibenzodioxin |
5.66 | 10696789 |
| MESH:D006330 |
Heart Defects, Congenital |
|
Tetrachlorodibenzodioxin |
2.55 | 10048152 11294989 |
| MESH:D006457 |
Hemoglobinuria, Paroxysmal |
|
Cyclosporine |
5.31 | 15720958 |
| MESH:D006470 |
Hemorrhage |
|
Tetrachlorodibenzodioxin |
3.89 | 11000095 |
| MESH:D006529 |
Hepatomegaly |
|
Tetrachlorodibenzodioxin |
3.65 | 16120746 15340226 12621046 |
| MESH:D006869 |
Hydronephrosis |
|
Tetrachlorodibenzodioxin |
5.12 | 8697196 16959395 15340226 16354765 18606429 |
| MESH:D006973 |
Hypertension |
|
Cyclosporine |
5.43 | 10903974 |
| MESH:D006973 |
Hypertension |
|
Tetrachlorodibenzodioxin |
5.43 | 18670907 18850075 |
| MESH:D007249 |
Inflammation |
|
Tetrachlorodibenzodioxin |
2.06 | 12878042 12200463 |
| MESH:D007569 |
Jaw Abnormalities |
|
Tetrachlorodibenzodioxin |
3.89 | 16580747 |
| MESH:D007638 |
Keratoconjunctivitis Sicca |
|
Cyclosporine |
5.51 | 15604871 |
| MESH:D007674 |
Kidney Diseases |
|
Cyclosporine |
2.58 | 8314463 10903974 18776723 |
| MESH:D007680 |
Kidney Neoplasms |
|
Cyclosporine |
3.17 | 12371664 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tetrachlorodibenzodioxin |
1.25 | 12878042 |
| MESH:D008113 |
Liver Neoplasms |
|
Tetrachlorodibenzodioxin |
1.85 | 16984957 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
Tetrachlorodibenzodioxin |
2.38 | 12151625 |
| MESH:D008175 |
Lung Neoplasms |
|
Tetrachlorodibenzodioxin |
1.24 | 11884234 19555203 |
| MESH:D008664 |
Metal Metabolism, Inborn Errors |
|
Cyclosporine |
5.86 | 16801185 |
| MESH:D017202 |
Myocardial Ischemia |
|
Tetrachlorodibenzodioxin |
3.43 | 12213967 |
| MESH:D009402 |
Nephrosis, Lipoid |
|
Cyclosporine |
5.51 | 17954296 |
| MESH:D009404 |
Nephrotic Syndrome |
|
Cyclosporine |
3.75 | 19348381 18481113 |
| MESH:D009421 |
Nervous System Malformations |
|
Tetrachlorodibenzodioxin |
3.89 | 14600291 |
| MESH:D010382 |
Peliosis Hepatis |
|
Tetrachlorodibenzodioxin |
5.32 | 12520081 |
| MESH:D017119 |
Porphyria Cutanea Tarda |
|
Tetrachlorodibenzodioxin |
4.23 | 18163543 |
| MESH:D011230 |
Precancerous Conditions |
|
Cyclosporine |
3.69 | 12371664 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Tetrachlorodibenzodioxin |
4.08 | 11118676 11222880 11399792 11896295 |
| MESH:D011565 |
Psoriasis |
|
Cyclosporine |
2.35 | 16882103 |
| MESH:D015619 |
Respiratory System Abnormalities |
|
Tetrachlorodibenzodioxin |
4.51 | 18990726 |
| MESH:D012878 |
Skin Neoplasms |
|
Tetrachlorodibenzodioxin |
2.23 | 16192470 |
| MESH:D013959 |
Thyroid Diseases |
|
Tetrachlorodibenzodioxin |
4.97 | 12697716 |
| MESH:D014605 |
Uveitis |
|
Cyclosporine |
5.05 | 1336536 |
| MESH:D054079 |
Vascular Malformations |
|
Tetrachlorodibenzodioxin |
5.66 | 12125929 |
| MESH:D019282 |
Wasting Syndrome |
|
Tetrachlorodibenzodioxin |
5.32 | 15886252 |
| MESH:D014985 |
Xerophthalmia |
|
Cyclosporine |
5.51 | 17120751 |
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