AutismKB 2.0

Annotation Detail for CYB5B


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Basic Information Top
Gene Symbol:CYB5B ( CYB5-M,CYPB5M,DKFZp686M0619,OMB5 )
Gene Full Name: cytochrome b5 type B (outer mitochondrial membrane)
Band: 16q22.1
Quick LinksEntrez ID:80777; OMIM: 611964; Uniprot ID:CYB5B_HUMAN; ENSEMBL ID: ENSG00000103018; HGNC ID: 24374
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CYB5B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CYB5B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CYB5B mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in increased expression of CYB5B mRNAincreases expression 19441803
D016572 Cyclosporine Cyclosporine results in decreased expression of CYB5B mRNAdecreases expression 20106945
C012279 dibutylnitrosamine [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to dibutylnitrosamineaffects cotreatment|increases response to substance 11733072
D004052 Diethylnitrosamine [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Diethylnitrosamineaffects cotreatment|increases response to substance 11733072
D004128 Dimethylnitrosamine [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Dimethylnitrosamineaffects cotreatment|increases response to substance 11733072
C056933 fumonisin B1 fumonisin B1 results in decreased expression of CYB5B mRNAdecreases expression 16221962
D008694 Methamphetamine Methamphetamine results in increased expression of CYB5B mRNAincreases expression 19149911
D009602 Nitrosamines [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Nitrosaminesaffects cotreatment|increases response to substance 11733072
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of CYB5B mRNAincreases expression 17616710
C013161 N-nitroso(di-n-propyl)amine [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to N-nitroso(di-n-propyl)amineaffects cotreatment|increases response to substance 11733072
C006253 pirinixic acid pirinixic acid results in increased expression of CYB5B mRNAincreases expression 18301758
15302862
D011374 Progesterone Progesterone results in increased expression of CYB5B mRNAincreases expression 18070364
C025462 sulindac sulfide sulindac sulfide results in decreased expression of CYB5B mRNAdecreases expression 12734198
D013752 Tetracycline Tetracycline results in increased expression of CYB5B mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 2.8816033868
MESH:D000236 Adenoma Diethylnitrosamine 6.926695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 6.9219555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.0718056438 19061943 17620307 17162532 19052882 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.0716434500
MESH:D000380 Agranulocytosis Clozapine 5.0414617031 16160616 12649775
MESH:D000544 Alzheimer Disease sulindac sulfide 3.0818759972
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1319483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415845082 15665606 15380490
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2517474063
MESH:D001943 Breast Neoplasms Progesterone 2.2515562024 16175315 17614352
MESH:D002277 Carcinoma Dimethylnitrosamine 4.0019555203
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.5016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.503084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.5018056438 19052882 16502159 3084413 16328049 17761372 18691550 17055752 19208518 20935162 16569478 19919837 20432363 19335982 16681979 20214788 20727157 18393292 20007298 20514400 16830150 19171122 19418558 10672840 10737359 16878318 18785209 17978847 18665156 3581430 19822196 18788625 16540662 18506893 11831363 17138121 16779866 17173139 21159647 17428255 18971187 19701751 16807293 19519916 20084675 16288022 18494052 16935385 19383236 19539802 19107877 19394651 16698587 18210153 20101231 17162532 20512989 18978308 20524982
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4412391285
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.9416033868
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.5617174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.6719052882
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D003072 Cognition Disorders Clozapine 4.9517123785
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6816402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.6820387270
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5515331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2110663392 19416960 16781746 11287661 14725611 11834606 14550746 16227642 19739265 14986274 11529661 10915739 10774834 12705907 17562736 12958197 2444490 16109766 19085960 17522070 16081117 11421492 15619225 18071297 19923254 11461765 12540782 17906064 12594235 11739529 16393943 19370779 18713872 16485898 15968718 16177239 19164858 11743745 12153990 19420014 12392966
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.2119107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 15.218172417
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 15.2116221962
MESH:D056486 Drug-Induced Liver Injury Tetracycline 15.2117522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D050171 Dyslipidemias Clozapine 4.1716402076
MESH:D004487 Edema pirinixic acid 2.4612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7617692515
MESH:D004715 Endometriosis Progesterone 3.7516134523
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms dibutylnitrosamine 10.6612706858
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 10.6617016578
MESH:D004938 Esophageal Neoplasms Nitrosamines 10.6612397637
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.6615264214 15150132 15623463 15547733 16510608 15878914 16805852 16704527 15547721
MESH:D005234 Fatty Liver Cyclosporine 18.6519224547
MESH:D005234 Fatty Liver Diethylnitrosamine 18.6521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 18.6520131406 19236843
MESH:D005234 Fatty Liver Tetracycline 18.6519224547 16917069
MESH:D005355 Fibrosis Cyclosporine 3.1312168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006529 Hepatomegaly fumonisin B1 8.7216221962
MESH:D006529 Hepatomegaly pirinixic acid 8.7219176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006948 Hyperkinesis Clozapine 11.8016046005
MESH:D006948 Hyperkinesis Methamphetamine 11.8017658665
MESH:D006973 Hypertension Cyclosporine 2.0910903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007249 Inflammation Diethylnitrosamine 5.1318785209
MESH:D007249 Inflammation Progesterone 5.1315869954
MESH:D007333 Insulin Resistance pirinixic acid 2.6216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.7515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.758314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2112371664
MESH:D008064 Lipidoses Clozapine 3.9417567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8120032147 18522880 18665156 18407596 19638242
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 2.5815798949 15504291 17724770 15366600 18637143 17881167 17198567 15733078 16009107 17196135 18567088 18237412 16169303 16270385 17203207 16570917 14643895 15081153 18239293 15086199 15571005 15138612 17534399 15298665 15577212 15793283 15161499 17666798 15369754 15492853 14709902 18629640 17201889 18095165 15479170 16544323 17465448 15339415 14568256 15842777 16042886 15744066 15067225 12918455 15864749 18364076 14726149 17640959 17348192 15591649 15383259 18210741 18672772 17036385 15942678 15099470 16627068 15723089 12925901 14659978 17432682 17719030 16603200 18371158 15763062
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5815474484
MESH:D008107 Liver Diseases Acetaminophen 3.8919460945 16611625 12969438 11587558 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8917034775
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6117185352 16871587
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.6117457977
MESH:D008113 Liver Neoplasms dibutylnitrosamine 10.7915881669
MESH:D008113 Liver Neoplasms Diethylnitrosamine 10.7920501860 19255062 20101389 19850985 21071580 21047994 2862719 20434301 18977376 19073162 19642983 15885732 15175105 19090486 18978307 21167192 19254457 2422723 20118626 20583210 18648771 19427195 19426721 19551842 20492335 19996281 12112319 16942905 19812893 10737359 21278145 19690152 19833225 19638242 19256749 20137499 19294768 18644402 12771043 9163691 20405173 19499222 18754104 20452335
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 10.7915890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 10.7915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.1717942915 3124819 16267830 17854601 18079962 16842330 18093689 21159647 19009564 18164116 19539802 18253720 18544905 18308698 18775883 18282651 19004024 19126423 2563599 9362446 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 6.1715603536 6150874 1848544
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7020970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 2.7016061637 19555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.8511408345 17203775
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D001523 Mental Disorders Clozapine 3.9416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3919142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.569029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009395 Nephritis, Interstitial Tetracycline 4.789884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009765 Obesity Clozapine 4.6818515891 19142110
MESH:D009765 Obesity pirinixic acid 4.6820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4112819281 16049721
MESH:D010051 Ovarian Neoplasms Progesterone 2.5217393432 16525653
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.4311026799
MESH:D011230 Precancerous Conditions Cyclosporine 8.8812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.882563599
MESH:D017096 Prion Diseases Tetracycline 5.4010903871
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011618 Psychotic Disorders Clozapine 4.1715331141
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012559 Schizophrenia Clozapine 2.7320107430 20521326 16141801 11763009 18855531 17726453 20580759 17667964 11151749 20521320 19369910 20168265 18806925 17123785 20452607
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5218551238
MESH:D013119 Spinal Cord Injuries Progesterone 4.2716503802 15862959
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.2712587719
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.5118456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.5116033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.5117575124 12958204
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.977505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.8816049721
MESH:D001749 Urinary Bladder Neoplasms dibutylnitrosamine 5.8812706858
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.6418645019
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D015430 Weight Gain Clozapine 4.4517502770 20107430 20521320 20564506 16141801 16402076
MESH:D015431 Weight Loss Clozapine 5.0717933447
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03014 - Heme
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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