AutismKB 2.0

Annotation Detail for ASXL3


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Basic Information Top
Gene Symbol:ASXL3 ( KIAA1713 )
Gene Full Name: additional sex combs like 3 (Drosophila)
Band: 18q12.1
Quick LinksEntrez ID:80816; OMIM: NA; Uniprot ID:ASXL3_HUMAN; ENSEMBL ID: ENSG00000141431; HGNC ID: 29357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ASXL3 mRNAaffects expression 17562736
D014635 Valproic Acid Valproic Acid results in increased expression of ASXL3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 4.378875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.4819490988
MESH:D000550 Amblyopia Valproic Acid 6.3017688650
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.9817497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 18177632 18558336 19460635 17507914 19232924 18985861 18396377 15238991 16609825 17688650 18940202 18316065 18775368 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.2817594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.698888407
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8420734317
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9116575769 17688650 8888407
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1510915739 17906064 11529661 14725611 11287661 11461765 18713872 19416960 12705907 16177239 10663392 19739265 11743745 15968718 18071297 19085960 11739529 16781746 10774834 16081117 19923254 16109766 12540782 12594235 15619225 2444490 19164858 17522070 11421492 17562736 12153990 16485898 14986274 19420014 14550746 12958197 16393943 12392966 11834606 16227642 19370779
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.151733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D004421 Dystonia Valproic Acid 4.661851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.9217275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.1418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 4.067562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 5.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.953659116
MESH:D005234 Fatty Liver Valproic Acid 3.8514986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.9616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.8118558336 8888407
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006849 Hydrocephalus Valproic Acid 5.7517688650
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4412587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.2116294345 17596541
MESH:D008107 Liver Diseases Acetaminophen 1.7119784758 16611625 19460945 12969438 19014921 11587558 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7417185352 16871587
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 5.3317228818
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D008881 Migraine Disorders Valproic Acid 3.5318803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.588888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.4017596541
MESH:D009436 Neural Tube Defects Valproic Acid 3.4216359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.7120603192
MESH:D019310 Pseudolymphoma Valproic Acid 5.6112752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.7819155313
MESH:D012559 Schizophrenia Valproic Acid 2.1115737665 19110320
MESH:D012640 Seizures Valproic Acid 3.0511044598 3137016 14763951 16876388 1511512 11738929 17978042 15475178
MESH:D016135 Spinal Dysraphism Valproic Acid 4.1719490988
MESH:D013226 Status Epilepticus Valproic Acid 5.6112833885
MESH:D014178 Translocation, Genetic Valproic Acid 6.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 5.413119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.418888407
MESH:D014581 Urticaria Acetaminophen 3.5810982225
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018