AutismKB 2.0

Annotation Detail for SSPN


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Basic Information Top
Gene Symbol:SSPN ( DAGA5,KRAG,NSPN,SPN1,SPN2,nanospan )
Gene Full Name: sarcospan (Kras oncogene-associated gene)
Band: 12p11.2
Quick LinksEntrez ID:8082; OMIM: 601599; Uniprot ID:SSPN_HUMAN; ENSEMBL ID: ENSG00000123096; HGNC ID: 11322
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SSPN mRNAincreases expression 18648102
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNAaffects cotreatment|decreases expression 12634122
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNAaffects cotreatment|increases expression 17183730
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNAaffects cotreatment|decreases expression 12634122
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of SSPN mRNAaffects cotreatment|decreases expression 12634122
D018038 Sodium Selenite Sodium Selenite results in decreased expression of SSPN mRNAdecreases expression 18175754
C004648 testosterone enanthate testosterone enanthate affects the expression of SSPN mRNAaffects expression 17440010
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of SSPN mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of SSPN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1216712894 17306315
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D001008 Anxiety Disorders Valproic Acid 9.2317497229
MESH:D001008 Anxiety Disorders vinclozolin 9.2319015723
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 17688650 18316065 17157402 18985861 19232924 18177632 17507914 18558336 19460635 18396377 16609825 15238991 20603192 18940202
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.093581430 7296757
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0916507464 15276417 17306315
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.057505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.0519524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D019465 Craniofacial Abnormalities lead acetate 3.2019769572
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.2017688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.972524372 18759878 8156756 11298694 11906362 8970840 14531868 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.516679447 8291058 1440618 18692083 16192314 18289764 9328219 9653073 11289319 18648102 6482804 9022650 7440962
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5115131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.5119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.333659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.1316628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0018234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver Valproic Acid 3.4419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation lead acetate 11.7419769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 11.7418558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8716452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9617440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.2712676792
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8016612254
MESH:D007248 Infertility, Male sodium arsenite 7.1515346721 12646999
MESH:D007248 Infertility, Male vinclozolin 7.1516467254
MESH:D007333 Insulin Resistance Sodium Selenite 3.3614714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007674 Kidney Diseases Cadmium Chloride 6.6816962696
MESH:D007674 Kidney Diseases sodium arsenite 6.6820008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008113 Liver Neoplasms sodium arsenite 2.4116712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.613712494 1399818 6587162 598648
MESH:D008171 Lung Diseases sodium arsenite 3.2619095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D008175 Lung Neoplasms sodium arsenite 1.8919931552 17306315 17077188 15276417 16712894
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008545 Melanoma sodium arsenite 2.0519082730 16487513
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms sodium arsenite 2.5611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8420056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.666679447
MESH:D009436 Neural Tube Defects sodium arsenite 12.6612854658
MESH:D009436 Neural Tube Defects Valproic Acid 12.6616359493 8888407
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4717306315 15276417
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.3820603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.3818220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3118760546
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8315475178 14763951 1511512 17978042 16876388 3137016 11738929 11044598
MESH:D012878 Skin Neoplasms sodium arsenite 2.7519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 9.9112854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.997505956 6582329 3712494 6587162 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.258074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2516452187 11723127 16712894 17306315
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9011813266
MESH:D014652 Vascular Diseases sodium arsenite 4.6217056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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