AutismKB 2.0

Annotation Detail for TAS1R2


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Basic Information Top
Gene Symbol:TAS1R2 ( GPR71,T1R2,TR2 )
Gene Full Name: taste receptor, type 1, member 2
Band: 1p36.13
Quick LinksEntrez ID:80834; OMIM: 606226; Uniprot ID:TS1R2_HUMAN; ENSEMBL ID: ENSG00000179002; HGNC ID: 14905
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04973Carbohydrate digestion and absorption
hsa04742Taste transduction
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Parkinson's disease
NEUROLOGICAL
Desease Name
Parkinson's disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C039464 1,6-dichlorosucrose 1,6-dichlorosucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20173092
C039463 1-chlorosucrose 1-chlorosucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20173092
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of TAS1R2 mRNAaffects expression 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TAS1R2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of TAS1R2 mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of TAS1R2 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TAS1R2 mRNA]affects expression|affects reaction 19414516
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TAS1R2 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of TAS1R2 mRNAaffects expression 17331233
D001218 Aspartame Aspartame binds to and results in increased activity of TAS1R2 proteinaffects binding|increases activity 20173092
D001218 Aspartame Aspartame binds to TAS1R2 proteinaffects binding 15353592
D001218 Aspartame Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]affects binding 17168764
D001218 Aspartame lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
D003494 Cyclamates Cyclamates binds to [TAS1R2 protein binds to TAS1R3 protein]affects binding 17168764
D003494 Cyclamates Cyclamates results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]affects binding|increases activity 17935609
D003494 Cyclamates lactisole inhibits the reaction [Cyclamates results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
C495512 lactisole lactisole binds to [TAS1R2 protein binds to TAS1R3 protein]affects binding 17168764
C495512 lactisole lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
C495512 lactisole lactisole inhibits the reaction [Cyclamates results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
C495512 lactisole lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
C013613 neohesperidin dihydrochalcone lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]affects binding|decreases reaction|increases activity 17935609
C013613 neohesperidin dihydrochalcone neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]affects binding|increases activity 17935609
C404525 neotame neotame binds to and results in increased activity of TAS1R2 proteinaffects binding|increases activity 20173092
C404525 neotame neotame binds to TAS1R2 proteinaffects binding 15353592
C404525 neotame neotame binds to [TAS1R2 protein binds to TAS1R3 protein]affects binding 17168764
C404525 neotame neotame results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20173092
C006253 pirinixic acid pirinixic acid results in decreased expression of TAS1R2 mRNAdecreases expression 17950772
D013395 Sucrose Sucrose binds to and results in increased activity of TAS1R2 proteinaffects binding|increases activity 20173092
D013395 Sucrose Sucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20173092
D013549 Sweetening Agents Sweetening Agents binds to and results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20302879
D013549 Sweetening Agents Sweetening Agents binds to TAS1R2 proteinaffects binding 20302879
C026285 trichlorosucrose trichlorosucrose binds to TAS1R2 proteinaffects binding 20302879
C026285 trichlorosucrose trichlorosucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]affects binding|increases activity 20173092
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5016434500
MESH:D000755 Anemia, Sickle Cell Aspartame 6.0711372003
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001172 Arthritis, Rheumatoid Aspartame 4.0310777254
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1519483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002779 Cholestasis pirinixic acid 2.8319176532
MESH:D003731 Dental Caries Aspartame 6.968955999
MESH:D017449 Dermatitis, Allergic Contact Aspartame 4.7214996049
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.5917562736 12705907 14725611 12540782 16393943 10774834 16109766 18071297 11834606 11743745 16781746 11739529 17522070 12153990 12392966 11529661 19370779 17906064 16485898 18713872 19420014 14550746 19923254 10663392 12958197 2444490 16227642 19416960 19164858 19739265 11287661 11421492 19085960 15968718 12594235 15619225 16177239 11461765 16081117 14986274 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004487 Edema pirinixic acid 2.4912083418
MESH:D004893 Erythema Nodosum Aspartame 6.969324739
MESH:D005141 Eyelid Diseases Aspartame 6.4114996049
MESH:D005234 Fatty Liver pirinixic acid 2.7719236843 20131406
MESH:D005334 Fever Aspartame 5.339630831
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006529 Hepatomegaly pirinixic acid 3.0116221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006973 Hypertension Aspartame 4.2418708962
MESH:D007333 Insulin Resistance pirinixic acid 2.6316306350
MESH:D007674 Kidney Diseases Acetaminophen 6.5915629191 12587719
MESH:D007674 Kidney Diseases Aspartame 6.5911409539
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6312587719 19460945 11587558 19014921 19784758 12969438 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8220007298 16377806 15890375
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0417365036
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1816966607 16166281 18303189
MESH:D008881 Migraine Disorders Aspartame 4.8818627677 10792367
MESH:D020326 Migraine without Aura Cyclic AMP 5.1611304026
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9516411023
MESH:D009369 Neoplasms Aspartame 5.5616507461
MESH:D009369 Neoplasms pirinixic acid 5.5617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010003 Osteoarthritis Aspartame 4.879630831
MESH:D010146 Pain Acetaminophen 7.2416870215
MESH:D010146 Pain Aspartame 7.249630831
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9110923243
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0317975199 17322281 15814490 17365031
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D012859 Sjogren's Syndrome Aspartame 6.6116800424
MESH:D013921 Thrombocytopenia Aspartame 5.4817534100
MESH:D014581 Urticaria Acetaminophen 2.9810982225
Pathway ID Pathway Name
KEGG:04973 Carbohydrate digestion and absorption
REACT:14797 Signaling by GPCR
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00168 agonist Aspartame Dietary supplement;Micronutrient;Sweetening Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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