AutismKB 2.0

Annotation Detail for FXR1


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Basic Information Top
Gene Symbol:FXR1 ( FXR1P )
Gene Full Name: fragile X mental retardation, autosomal homolog 1
Band: 3q26.33
Quick LinksEntrez ID:8087; OMIM: 600819; Uniprot ID:FXR1_HUMAN; ENSEMBL ID: ENSG00000114416; HGNC ID: 4023
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
schizophrenia
Desease Name
Schizophrenia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of FXR1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FXR1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FXR1 mRNAdecreases expression 20018196
19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of FXR1 mRNAaffects expression 17484886
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of FXR1 mRNAdecreases expression 17490981
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of FXR1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXR1 mRNAaffects cotreatment|increases expression 17942748
C421324 pateamine A pateamine A affects the localization of FXR1 proteinaffects localization 16951406
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of FXR1 mRNAdecreases expression 17616710
D012643 Selenium Selenium results in decreased expression of FXR1 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the localization of FXR1 proteinaffects localization 16951406
C004648 testosterone enanthate testosterone enanthate affects the expression of FXR1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of FXR1 mRNAdecreases expression 17101203
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FXR1 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E Vitamin E results in decreased expression of FXR1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.2916124888 15721981 16011737 15673190 18705752 16227642 10355542 15700767 16097048 3786805 16192424 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.2916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.663084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.6618788625
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6617306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4018572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.536135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5320889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.5320056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 17681005 17110522 16105132 15861022 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.138697196 12621046 15340226 16354765 15668235
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6720423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2512958197 10663392 12705907 14725611 19416960 18713872 17522070 16781746 17906064 12540782 10915739 12392966 19739265 11739529 11834606 12153990 16227642 11743745 19420014 10774834 11287661 2444490 16177239 15619225 19164858 14550746 14986274 16485898 18071297 19923254 15968718 17562736 11421492 12594235 11461765 11529661 16109766 19370779 19085960 16393943 16081117
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.2515998439 16227642 3786805 17522070 6623471 7179309 6884620 2869522 7120509 7440962 10092053 15027814 19336974 9327722 3732212 4309450 15968718 21278145 11566570 10915739 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.9612795759 17595544 12631006 61145 15959796 16239168 19224547 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 8.9518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7011294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8212646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8912200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 10.3312587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 10.3320008137
MESH:D007674 Kidney Diseases Vitamin E 10.3312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.0416705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516943688 21278145 11408273 16239168 11903743 17334410 17157831 17174718 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5117708605 12546737 17721639 12445418 16248980 16015684 15338365 17714472 17761835 17922224 18210741 14748882 12632514 18472332 18205269 18395914 15730626 15818738 10355542 18054572 17805973 15931870 13678700 17557913 18279442 17481882 15673190 17698563 16033810 12389079 12649538 14620537 12445421 18006644 18277467 16638106 12609069 12898905 15996030 15925388 18156304 18251166 17631135 14716496 18429990 18412020 16097048 17869086 18166357 18376398 15052691 14512876 18705752 15370692 11481614 12666154 17976157 17823541 16027843 14724832 16116963 12667390 18187930 17640975 18317297 12586293 15362042 18472094 14716833 17900296 18418968 16136751 12632512 20821823 15057751 15959796 18481824 12741479 15123356 18395095 12958196 18420326 16192424 18263696 17766677 15876570 15893842 17944888 16011737 18339082 17565644 17525996 15650968
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5112878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5116169303
MESH:D008107 Liver Diseases Acetaminophen 3.9616611625 19784758 16610002 19460945 11587558 12969438 12587719 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9615720792 17285989 16246199 15830285 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6714706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.937678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.9319294768
MESH:D008113 Liver Neoplasms sodium arsenite 10.9315276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.076135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.0715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0712151625
MESH:D008171 Lung Diseases sodium arsenite 7.6219095001
MESH:D008171 Lung Diseases Vitamin E 7.6216863852
MESH:D008175 Lung Neoplasms sodium arsenite 3.4519931552 16712894 17077188 15276417 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4519555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8115318939
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.987678174 18551238
MESH:D009369 Neoplasms sodium arsenite 2.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4617306315 15276417
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2916039940
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.7118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.0615864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1916049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.1916452187 17306315 11723127 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28439
    • No data
    Releated disease ID Related disease Name
    PA447027Muscular Dystrophy, Facioscapulohumeral
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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