AutismKB 2.0

Annotation Detail for COLEC12


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Basic Information Top
Gene Symbol:COLEC12 ( CLP1,NSR2,SCARA4,SRCL )
Gene Full Name: collectin sub-family member 12
Band: 18p11.32
Quick LinksEntrez ID:81035; OMIM: 607621; Uniprot ID:COL12_HUMAN; ENSEMBL ID: ENSG00000158270; HGNC ID: 16016
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of COLEC12 mRNAaffects expression 17562736
D016589 Astemizole Astemizole results in decreased expression of COLEC12 mRNAdecreases expression 20221588
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of COLEC12 mRNAincreases expression 19737606
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COLEC12 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of COLEC12 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of COLEC12 mRNAincreases expression 20106945
D002794 Choline Choline affects the expression of COLEC12 mRNAaffects expression 17616785
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COLEC12 mRNAaffects cotreatment|increases expression 18164116
D002117 Calcitriol Calcitriol results in increased expression of COLEC12 mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of COLEC12 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of COLEC12 mRNAincreases expression 19619570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of COLEC12 mRNAdecreases expression 17557909
D010656 Phenylephrine Phenylephrine results in decreased expression of COLEC12 mRNAdecreases expression 18158353
C006253 pirinixic acid pirinixic acid results in increased expression of COLEC12 mRNAincreases expression 18445702
C116926 rofecoxib rofecoxib results in decreased expression of COLEC12 mRNAdecreases expression 17070997
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of COLEC12 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of COLEC12 mRNAincreases expression 20106945
19619570
C025643 vinclozolin vinclozolin affects the expression of COLEC12 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.0820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.0811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0814692618
MESH:D000236 Adenoma Benzo(a)pyrene 11.396695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.3919389873
MESH:D000236 Adenoma Diethylnitrosamine 11.3910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.7819061943 18056438 16434500 17162532 19052882 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 12.3610982225
MESH:D000799 Angioedema Astemizole 12.362883202
MESH:D001008 Anxiety Disorders vinclozolin 3.6819015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1617460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7815885639
MESH:D001169 Arthritis, Experimental rofecoxib 7.7816690336
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Choline 2.3516818868
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001919 Bradycardia Phenylephrine 4.6315306635
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3420146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.3411237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3417474063
MESH:D001943 Breast Neoplasms Estradiol 2.3416675129 12948864 17261762 14630087 17018787 17289903 19861407 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.563084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.5616681979 19919837 18691550 19335982 18056438 17761372 20007298 18506893 10737359 18210153 20101231 3581430 17162532 19394651 18665156 17055752 20524982 16807293 19107877 19701751 19383236 18393292 19418558 10672840 19822196 18785209 18971187 20084675 21159647 3084413 18494052 19539802 20432363 17173139 11831363 16288022 16779866 16878318 16540662 19519916 16502159 18788625 20512989 17428255 19208518 17138121 16935385 20514400 16569478 19052882 16830150 19171122 20727157 20935162 16328049 17978847 18978308 16698587 20214788
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.7411237771
MESH:D006332 Cardiomegaly Phenylephrine 6.9817124262 16170337 15728586 11754973 11179087 17287366
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9818850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.827505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8816105132 15861022 17681005 17333356 16919318 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 7.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms rofecoxib 3.3112902858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.4114966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D002658 Developmental Disabilities Choline 4.7116818868
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D004244 Dizziness Astemizole 6.563105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2116109766 14550746 19420014 10915739 12392966 11287661 11739529 10663392 15619225 11529661 2444490 17906064 16485898 12153990 11743745 18071297 10774834 12540782 16393943 16177239 16081117 12958197 19370779 17522070 12594235 11421492 17562736 14725611 19164858 16781746 19923254 11461765 18713872 19416960 19085960 11834606 16227642 19739265 15968718 12705907 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.3115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.3112538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0119148513 11473722 18566989
MESH:D004715 Endometriosis rofecoxib 9.5015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.509294722 10568697
MESH:D004802 Eosinophilia Astemizole 4.871355641
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Diethylnitrosamine 13.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.3715345470
MESH:D005234 Fatty Liver pirinixic acid 13.3720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D005499 Folliculitis Astemizole 6.011671328
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4016417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5019176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Phenylephrine 5.378949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3718850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 4.6118502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7817937319
MESH:D007248 Infertility, Male vinclozolin 6.7816467254
MESH:D007249 Inflammation Diethylnitrosamine 4.9818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.3116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007410 Intestinal Diseases rofecoxib 5.1115831440
MESH:D007417 Intestinal Polyps rofecoxib 5.4311245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9815629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8116417039
MESH:D017513 Lichen Nitidus Astemizole 6.562563723
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8518407596 20032147 19638242 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 5.0317565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008107 Liver Diseases Acetaminophen 3.9512969438 16610002 19014921 12587719 19460945 16611625 19784758 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4521137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.4521295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.4519427195 18977376 15885732 20101389 2862719 15175105 16942905 19850985 20501860 19254457 19642983 20583210 19551842 21167192 20118626 19294768 18978307 20434301 21071580 19996281 2422723 19255062 19090486 19638242 19073162 20492335 12771043 19426721 10737359 20137499 19256749 18648771 9163691 20452335 21278145 19690152 19833225 21047994 19499222 20405173 12112319 18644402 18754104 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 14.4515890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4516984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.0618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.0618164116 17942915 18253720 3124819 19004024 19539802 9362446 18775883 19126423 16267830 17174075 19009564 21159647 18544905 2563599 18079962 19519916 18282651 18093689 18308698 17854601 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0612151625
MESH:D008133 Long QT Syndrome Astemizole 4.6411989578 18472280
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3820064080 17053015 20869020 18520028 18569708 20135361 18816296 6695378 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3821163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3819555203 11884234
MESH:D008288 Malaria Astemizole 4.7816816845
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5916891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.3320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2120387270
MESH:D009759 Nystagmus, Pathologic Astemizole 6.566135121
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010003 Osteoarthritis rofecoxib 4.4116690336
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010149 Pain, Postoperative rofecoxib 5.4918165598 16678543
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7711399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.7718042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0218220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5517292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5516289102 16644109 15754350 18247401 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.5516740699
MESH:D011472 Prostatitis vinclozolin 5.0218629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3916919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.5210822083
MESH:D012852 Sinusitis Phenylephrine 4.787327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3420155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3418456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.027505956
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D016171 Torsades de Pointes Astemizole 5.299583453 8256756
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014581 Urticaria Acetaminophen 9.2310982225
MESH:D014581 Urticaria Astemizole 9.233080510 1976298 1683191 2568013 2568189 3134034 2147912 2565098 2859714 2883202 3097109 2885854
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D014717 Vertigo Astemizole 6.563105558
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:04145 Phagosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26738
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    Releated drug ID Related drug Name
    PA450196letrozole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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