AutismKB 2.0

Annotation Detail for CALU


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Basic Information Top
Gene Symbol:CALU ( FLJ90608 )
Gene Full Name: calumenin
Band: 7q32.1
Quick LinksEntrez ID:813; OMIM: 603420; Uniprot ID:CALU_HUMAN; ENSEMBL ID: ENSG00000128595; HGNC ID: 1458
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Hemostasis
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Pathway IDPathway Name
500959Platelet degranulation
Related Diseases/Disorders Top
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Desease Name
PHARMACOGENOMIC
anticoagulant response of acenocoumarol
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CALU mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of CALU mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of CALU mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of CALU mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of CALU mRNAincreases expression 17522070
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CALU mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CALU mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of CALU mRNAdecreases expression 15336504
D002110 Caffeine Caffeine results in decreased expression of CALU mRNAdecreases expression 11793227
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CALU mRNAincreases expression 17522070
D002725 Chloroform Chloroform results in increased expression of CALU mRNAincreases expression 17522070
D016572 Cyclosporine Cyclosporine results in increased expression of CALU mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of CALU mRNAincreases expression 17522070
D004918 Erythromycin Estolate Erythromycin Estolate results in increased expression of CALU mRNAincreases expression 17522070
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of CALU mRNAincreases expression 17522070
D019800 Phenol Phenol results in decreased expression of CALU mRNAdecreases expression 17547211
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of CALU mRNAincreases expression 19244175
D013752 Tetracycline Tetracycline results in increased expression of CALU mRNAincreases expression 17522070
D013806 Theophylline Theophylline results in increased expression of CALU mRNAincreases expression 17522070
D013853 Thioacetamide Thioacetamide results in decreased expression of CALU mRNAdecreases expression 11793227
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of CALU mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of CALU mRNAincreases expression 19244175
D014859 Warfarin CALU protein results in decreased susceptibility to Warfarindecreases response to substance 11641264
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.703712494
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4817659584
MESH:D001249 Asthma Theophylline 3.8312113382 9701106
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001778 Blood Coagulation Disorders Thioacetamide 4.0919483382
MESH:D001859 Bone Neoplasms Phenol 5.1210556009
MESH:D001913 Bowen's Disease Phenol 5.6719293009
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.6416192424 16124888 15700767 16011737 18705752 16097048 3786805 10355542 15673190 15721981 16050911 16227642
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.6416050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.727296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.723084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7218788625
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.7217997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.637296757
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.506135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.507505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.5020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.5012371664
MESH:D002543 Cerebral Hemorrhage Warfarin 5.7611061249
MESH:D002637 Chest Pain Theophylline 5.7915238202
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.2118291259
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 6.1212912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 13.2015500046 18590720 16629650 18164287 12927374 15913567 7624871 19486331
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.2019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.2019486331
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.7710220858 19407337
MESH:D003092 Colitis Selenium 3.6917936198
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4815824018
MESH:D023903 Coronary Restenosis Warfarin 5.5912872399
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.7420579077 20497562
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.8317728286
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.8319769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 6.7618759878 8156756 11298694 11906362 14531868 12868966 2524372 8970840
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 6.7612438553
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.412952479 3621924
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 4.0318772604
MESH:D003928 Diabetic Nephropathies Warfarin 5.0212644472
MESH:D003967 Diarrhea Dexamethasone 3.617237001
MESH:D003875 Drug Eruptions Warfarin 5.8914723717
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 29.297624871 17522070 18289764 20133375
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 29.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 29.299653073 18692083 18648102 9328219 9022650 6679447 7440962 18289764 16192314 11289319 1440618 6482804 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 29.2917562736 14986274 10774834 19416960 19085960 11834606 2444490 16227642 16109766 11461765 19370779 18071297 12958197 17522070 16485898 11421492 16081117 14725611 16177239 16781746 16393943 15968718 12392966 12705907 19923254 12594235 12540782 11743745 19164858 10915739 14550746 11529661 17906064 12153990 11739529 15619225 18713872 19420014 11287661 10663392 19739265
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 29.2910092053 17522070 6884620 9327722 16227642 11566570 21278145 7120509 2869522 3732212 7440962 3786805 10915739 7179309 15968718 19336974 19085960 4309450 16177239 15027814 6623471 15998439
MESH:D056486 Drug-Induced Liver Injury Chloroform 29.297120509 7440962 6623471 17522070 2862719 6884620 3732212 3104120
MESH:D056486 Drug-Induced Liver Injury Erythromycin Estolate 29.2917522070 14998559
MESH:D056486 Drug-Induced Liver Injury Selenium 29.2915131321
MESH:D056486 Drug-Induced Liver Injury Tetracycline 29.2917522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 29.2912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004485 Eczema Dexamethasone 4.3712438553
MESH:D004487 Edema Dexamethasone 3.3219703484
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.313581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3120426865
MESH:D005218 Fat Necrosis Thioacetamide 5.6416456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.7512795759 16239168 12631006 17595544 15959796 19224547 16045604 61145
MESH:D005234 Fatty Liver Cyclosporine 12.7519224547
MESH:D005234 Fatty Liver Tetracycline 12.7519224547 16917069
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3818705752
MESH:D005355 Fibrosis Cyclosporine 8.3812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.6311794436
MESH:D005776 Gaucher Disease Warfarin 5.8712359135
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9416080930
MESH:D006333 Heart Failure Selenium 3.0217162251
MESH:D006406 Hematoma Warfarin 6.6317493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Warfarin 5.3718429757
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4917276928 18665440 15929193
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 28.4518590720
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 28.456705139
MESH:D006505 Hepatitis Caffeine 28.4511394713
MESH:D006505 Hepatitis Carbon Tetrachloride 28.4519110552 19900420
MESH:D006505 Hepatitis Thioacetamide 28.4516456712
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.877520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.8716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 5.2110903974
MESH:D006973 Hypertension Dexamethasone 5.2117042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D006976 Hypertension, Pulmonary Warfarin 4.7412359135
MESH:D007248 Infertility, Male Theophylline 4.3616988215
MESH:D007249 Inflammation Dexamethasone 2.8411099482 8960868
MESH:D007251 Influenza, Human Selenium 10.6916624496
MESH:D007251 Influenza, Human Vitamin E 10.6916624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.948074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D055623 Keratosis, Actinic Phenol 6.3619293009
MESH:D007674 Kidney Diseases Acetaminophen 9.7112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.7118776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 9.7112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8016518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.9416705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.946582329
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9412371664
MESH:D054068 Livedo Reticularis Warfarin 6.6318280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7611408273 11903743 17157831 16221502 16943688 16239168 21278145 17174718 17334410
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9418263696 12958196 14716833 15123356 18429990 18187930 18156304 17805973 15650968 15818738 17565644 12741479 16027843 15730626 15893842 12649538 12445421 18376398 18317297 12632512 17640975 17714472 15876570 18472332 18395095 18412020 12609069 17922224 18418968 17481882 17525996 12546737 12667390 15996030 18420326 12586293 16011737 12632514 17976157 18472094 18205269 18339082 13678700 16192424 16116963 16136751 10355542 17708605 15052691 16638106 15959796 15673190 17721639 17557913 18279442 14748882 11481614 16248980 17823541 17631135 15057751 17869086 12666154 18251166 12389079 17761835 14716496 18210741 16097048 18277467 18006644 15362042 14620537 18395914 20821823 15338365 14724832 12898905 15931870 17766677 17698563 17900296 17944888 15370692 12445418 16015684 15925388 14512876 18705752 18166357 18481824 16033810 18054572
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.9416718785
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.9411682029 15078482 15362042 12531686 17355460 18416461 15716488 18032466 18031379 17629604 15095483 15316131 18458672 16126171 12175628 11172339 18295389 11481614 15288472 17050028 15465738 15075984 18380797 15288473 17292413 17127702 16248980 14739098 15474484 12557150 15158331 16511523 16343077 18606216 18615449 12085344 18263696 12891558 15334695 18395095 16489207 16097051 12679928 16098781 10677585
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.9416169303
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 9.2617184895
MESH:D008107 Liver Diseases Acetaminophen 9.2616611625 19460945 11587558 19014921 12587719 12969438 16610002 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.2615830285 16964402 15720792 16246199 17285989
MESH:D008107 Liver Diseases Thioacetamide 9.2616337175 18374380 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.7917185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.7916899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 15.7912479984 15633222 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.457678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4519294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.522876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.52598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.5212014681 15583823
MESH:D008171 Lung Diseases Vitamin E 3.1216863852
MESH:D008175 Lung Neoplasms Dexamethasone 2.6615824018 11195469
MESH:D008175 Lung Neoplasms Vitamin E 2.6611062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7115318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008654 Mesothelioma Selenium 2.7615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009101 Multiple Myeloma Dexamethasone 3.4415867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.499809623
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.687678174 18551238
MESH:D009336 Necrosis Warfarin 10.6814723717
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.433581430
MESH:D009395 Nephritis, Interstitial Tetracycline 4.709884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.866679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.6216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.626482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010146 Pain Acetaminophen 6.8216870215
MESH:D010146 Pain Phenol 6.8217610455
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.7720133375
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.3511026799
MESH:D010392 Pemphigus Phenol 6.3616522979 17163923
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D010864 Pilonidal Sinus Phenol 6.3619655223 15622588
MESH:D010954 Plasmacytoma Selenium 4.8115087411
MESH:D011041 Poisoning Phenol 4.638825745
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4921297632
MESH:D017096 Prion Diseases Tetracycline 5.3310903871
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3315084515
MESH:D020151 Protein C Deficiency Warfarin 6.2618376272
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D029424 Pulmonary Disease, Chronic Obstructive Theophylline 5.0618983928
MESH:D011655 Pulmonary Embolism Warfarin 6.2619300499
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.9318379247 11700416
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4818551238
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.7812269725
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.658532709
MESH:D012893 Sleep Disorders Caffeine 5.2319395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 5.0217225163
MESH:D013088 Spermatocele Phenol 5.5618646496
MESH:D013272 Stomach Diseases Dexamethasone 4.2415472012
MESH:D013276 Stomach Ulcer Dexamethasone 3.4115138204
MESH:D020521 Stroke Vitamin E 8.9016517955
MESH:D020521 Stroke Warfarin 8.9019300499
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.6720133375
MESH:D013923 Thromboembolism Warfarin 6.0816960144 18698879
MESH:D019851 Thrombophilia Warfarin 5.5017493413
MESH:D013927 Thrombosis Warfarin 5.0417245631 19300499 11518727 17672075 11307788 15720958
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.827505956 6582329 3712494 1399818 6587162
MESH:D014277 Trigeminal Neuralgia Phenol 6.3616527771 10223447
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.8916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.898074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D014605 Uveitis Cyclosporine 11.501336536
MESH:D014605 Uveitis Dexamethasone 11.501336536
MESH:D014657 Vasculitis Warfarin 5.7820337814
MESH:D054556 Venous Thromboembolism Warfarin 6.2918776969
MESH:D020246 Venous Thrombosis Warfarin 5.4215733061 14723717
MESH:D014860 Warts Phenol 6.0219122958
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26047
    • Releated gene ID Related gene Name
    PA133787052VKORC1
    PA126CYP2C9
    Releated disease ID Related disease Name
    PA445465Pulmonary Embolism
    PA446969Venous Thrombosis
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448383amiodarone
    PA451363simvastatin
    PA451906warfarin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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