AutismKB 2.0

Annotation Detail for CAMK4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CAMK4 ( CaMK-GR,MGC36771 )
Gene Full Name: calcium/calmodulin-dependent protein kinase IV
Band: 5q22.1
Quick LinksEntrez ID:814; OMIM: 114080; Uniprot ID:KCC4_HUMAN; ENSEMBL ID: ENSG00000152495; HGNC ID: 1464
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa04722Neurotrophin signaling pathway
Pathway IDPathway Name
Synaptic Transmission
Signalling by NGF
Opioid Signalling
Pathway IDPathway Name
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200019Signaling events mediated by HDAC Class II
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
No data
Pathway IDPathway Name
500637CaMK IV-mediated phosphorylation of CREB
500182CREB phosphorylation through the activation of CaMKK
500183Activation of CaMK IV
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
2146Lupus erythematosus
Desease Name
CARDIOVASCULAR
blood pressure
Desease Name
Blood pressure
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CAMK4 mRNAdecreases expression 19933214
C104006 2',3',4',5'-tetrachloro-4-biphenylol 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Diethylstilbestrol results in increased activity of CAMK4 protein]decreases reaction|increases activity 16413991
C104006 2',3',4',5'-tetrachloro-4-biphenylol 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein]decreases reaction|increases activity 16413991
C103303 alitretinoin CAMK4 protein promotes the reaction [alitretinoin results in increased activity of RARA protein]increases activity|increases reaction 15773917
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CAMK4 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of CAMK4 proteindecreases expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CAMK4 mRNAdecreases expression 19410645
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CAMK4 proteindecreases expression 19410645
D003024 Clozapine Clozapine results in decreased expression of CAMK4 proteindecreases expression 19289156
D003024 Clozapine Clozapine results in increased expression of CAMK4 mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]decreases reaction|increases activity 11073891
D004054 Diethylstilbestrol 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Diethylstilbestrol results in increased activity of CAMK4 protein]decreases reaction|increases activity 16413991
D004054 Diethylstilbestrol Diethylstilbestrol results in increased activity of CAMK4 proteinincreases activity 16413991
D016291 Dizocilpine Maleate Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D004958 Estradiol 2',3',4',5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol results in increased activity of CAMK4 protein]decreases reaction|increases activity 16413991
D004958 Estradiol Estradiol results in increased activity of CAMK4 proteinincreases activity 16413991
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CAMK4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK4 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in decreased expression of CAMK4 proteindecreases expression 19289156
D006220 Haloperidol Haloperidol results in increased expression of CAMK4 mRNAincreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in decreased expression of CAMK4 mRNAdecreases expression 16807920
C063302 KN 62 KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]decreases reaction|increases activity 11073891
C072105 KN 93 KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D008094 Lithium Lithium results in increased expression of CAMK4 mRNAincreases expression 19711354
D008094 Lithium Lithium results in increased expression of CAMK4 proteinincreases expression 19711354
C008493 methylselenic acid methylselenic acid results in increased expression of CAMK4 mRNAincreases expression 12517777
D009151 Mustard Gas Mustard Gas results in decreased expression of CAMK4 mRNAdecreases expression 15674843
D009529 Nicardipine Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]decreases reaction|increases activity 11073891
D010126 Ozone Ozone results in decreased expression of CAMK4 mRNAdecreases expression 16330353
D010634 Phenobarbital Phenobarbital results in decreased expression of CAMK4 mRNAdecreases expression 12807726
D020891 Raclopride Raclopride results in decreased expression of CAMK4 proteindecreases expression 19289156
D018967 Risperidone Risperidone results in decreased expression of CAMK4 proteindecreases expression 19289156
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CAMK4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D013749 Tetrachlorodibenzodioxin KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the localization of CAMK4 proteinaffects localization 17973980
D013749 Tetrachlorodibenzodioxin Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D013779 Tetrodotoxin Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]affects localization|decreases reaction 17973980
D019284 Thapsigargin Thapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]decreases reaction|increases activity 11073891
D014050 Toluene Toluene results in increased expression of CAMK4 mRNAincreases expression 17870172
16737738
D014415 Tunicamycin Tunicamycin results in decreased expression of CAMK4 mRNAdecreases expression 17127020
D014700 Verapamil Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]decreases reaction|increases activity 11073891
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.426195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4215322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6311798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.6311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6314692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.2017620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D000380 Agranulocytosis Clozapine 4.8014617031 12649775 16160616
MESH:D000544 Alzheimer Disease Lithium 4.5019621015
MESH:D000544 Alzheimer Disease Ozone 4.5015513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2315469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5015885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5015570426
MESH:D020817 Asperger Syndrome Risperidone 5.2816401163
MESH:D001249 Asthma Mustard Gas 4.8110378619
MESH:D001249 Asthma Ozone 4.8117854713 16373670
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.6218349709
MESH:D001321 Autistic Disorder Haloperidol 2.8719368416 18080171
MESH:D001321 Autistic Disorder Risperidone 2.8719232924 16239862 15994720 18026891 18349709 19013209 15492353 19154706 19368416 18775368 16948927 18080171 18278980 16730335 16379507 16601648 17929164 17019624 15543515 17069546 15930063
MESH:D001714 Bipolar Disorder Lithium 7.7120338123 17594078 19153942 20046352
MESH:D001714 Bipolar Disorder Risperidone 7.7118278980 19154706
MESH:D001768 Blister Mustard Gas 4.9019167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.1816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D001943 Breast Neoplasms alitretinoin 1.9516344269
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9515324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9518497071 16675129 19861407 17289903 17018787 12948864 14630087 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4715516495 17626835 14754758 19059883 18315731 16777450 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7110378619 17687719
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002100 Cachexia Ozone 4.4816183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.2315073043 14691202 11135700 15553829 16217749
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.2315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.2316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.2320007298 1701930 17173139 20935162 6705139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218670907 16120746 18850075
MESH:D002375 Catalepsy Haloperidol 4.651977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.9812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.9818566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.994080065
MESH:D002547 Cerebral Palsy Toluene 5.599294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9416835633
MESH:D002779 Cholestasis Cyclosporine 7.1419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1416919318 15861022 17681005 17333356 16105132 17110522 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9915340226 12621046 8697196 15668235 16354765
MESH:D003072 Cognition Disorders Clozapine 4.7117123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7320055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Toluene 3.739294310
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3116002989 12952375
MESH:D007644 Darier Disease Lithium 5.6520338123
MESH:D003643 Death Toluene 5.406431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 16.9415213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 16.9420210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 16.9420210726
MESH:D003704 Dementia Haloperidol 9.7711575062
MESH:D003704 Dementia Risperidone 9.7711575062
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.4919244398
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.2816402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1919279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 13.5515331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 13.5516379507
MESH:D053207 Diurnal Enuresis Risperidone 6.4117822346
MESH:D004314 Down Syndrome Risperidone 4.8818349709
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.4720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5711462148
MESH:D050171 Dyslipidemias Clozapine 4.0016402076
MESH:D004421 Dystonia Phenobarbital 3.761851702
MESH:D004487 Edema Mustard Gas 6.0711428631 11402378 11428647 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.9816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 6.9811473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.853659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.613922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7620417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.326401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.997750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.763659116
MESH:D004890 Erythema Mustard Gas 4.909357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2512903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8211564622
MESH:D005234 Fatty Liver arsenic trioxide 11.7115073043
MESH:D005234 Fatty Liver Cyclosporine 11.7119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.7115345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5015751030 16611131 16002989 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005355 Fibrosis Cyclosporine 7.6312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006330 Heart Defects, Congenital Lithium 6.5619638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5610048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006529 Hepatomegaly Phenobarbital 7.5916109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5916120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.788697196 16959395 15340226 18606429 16354765
MESH:D006943 Hyperglycemia Risperidone 4.9318278980
MESH:D006948 Hyperkinesis Clozapine 4.6516046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1814722030 12960047
MESH:D006973 Hypertension Cyclosporine 8.1610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1618670907 18850075
MESH:D006973 Hypertension Verapamil 8.1617700361
MESH:D007021 Hypospadias Diethylstilbestrol 10.3816002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.3816569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.1015036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3217937319
MESH:D007249 Inflammation Mustard Gas 4.6017524151 9357497 8975870 9260866 11428647 11402378 11428620 11428631 16001271
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.8016393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3716144296
MESH:D007674 Kidney Diseases Cyclosporine 5.4410903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 5.4415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.2112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.2115003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.2115610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8117184923
MESH:D007938 Leukemia arsenic trioxide 2.7015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0917050201 20471514 19850784 16467208 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0519225113 17217047 17869043 16331271 16966277 15748426 12679006 16330433 16823087 19642359 15622746 15336539 15213294 11468182 9834237 17107899 17712046 19035177 12712474 12018890 17649720 16112521 19075265 11161223 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1016882451
MESH:D008064 Lipidoses Clozapine 3.7717567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7521047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.1714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Phenobarbital 2.1119363144
MESH:D008113 Liver Neoplasms arsenic trioxide 9.8814682389
MESH:D008113 Liver Neoplasms Diethylstilbestrol 9.8815890375 16712894
MESH:D008113 Liver Neoplasms Phenobarbital 9.8815975961 21047994 8742319 19812893 19073162 19482888
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.8816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.8820377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.882563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.8812151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D008171 Lung Diseases Mustard Gas 7.0418161513 18702808
MESH:D008171 Lung Diseases Ozone 7.048266340 19066396
MESH:D055370 Lung Injury Ozone 3.5920417186
MESH:D008175 Lung Neoplasms alitretinoin 6.2416413115
MESH:D008175 Lung Neoplasms arsenic trioxide 6.2419825857 11798837
MESH:D008175 Lung Neoplasms Mustard Gas 6.243148597 8781369
MESH:D008175 Lung Neoplasms Ozone 6.247614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2516002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4016891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D001523 Mental Disorders Clozapine 11.9316856516
MESH:D001523 Mental Disorders Haloperidol 11.9316856516
MESH:D001523 Mental Disorders Risperidone 11.9316856516 16596465
MESH:D008607 Mental Retardation Risperidone 6.3618349709
MESH:D008607 Mental Retardation Toluene 6.369294310
MESH:D024821 Metabolic Syndrome X Clozapine 9.4819142101
MESH:D024821 Metabolic Syndrome X Risperidone 9.4819142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D008679 Metaplasia Ozone 4.8410496685
MESH:D019964 Mood Disorders Risperidone 5.5717019624
MESH:D019957 Motor Skills Disorders Toluene 4.999294310
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9219417148 11468182 15949261 14977855 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9916105982 16882451
MESH:D009203 Myocardial Infarction Lithium 3.8216288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0816810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2117484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7116624393
MESH:D009369 Neoplasms alitretinoin 5.0916946489
MESH:D009369 Neoplasms Diethylstilbestrol 5.0915313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0619348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 14.9211399458
MESH:D009421 Nervous System Malformations Estradiol 14.9216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.9214600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9510525206
MESH:D009503 Neutropenia Mustard Gas 3.737688884 16761898
MESH:D053206 Nocturnal Enuresis Risperidone 6.0617822346
MESH:D009765 Obesity Clozapine 2.9519142110 18515891
MESH:D010018 Osteomalacia Phenobarbital 4.1017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5412452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 4.5419401270
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.9815580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 4.9816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D020734 Parkinsonian Disorders Raclopride 5.6012476322
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010538 Peritonitis Ozone 3.8716369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4115687265 16977796
MESH:D011014 Pneumonia Ozone 4.1318007984 18929643 18381685
MESH:D011041 Poisoning Mustard Gas 3.5615727166
MESH:D017499 Porokeratosis alitretinoin 5.7416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2412371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.242563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.6917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6911896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6520887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1719131511
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1715046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1716740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1716205645
MESH:D011537 Pruritus Ethinyl Estradiol 8.6516919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.6518058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.2312752131
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.7011575062
MESH:D011618 Psychotic Disorders Clozapine 8.5415331141
MESH:D011618 Psychotic Disorders Haloperidol 8.5411575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8317894541 17620002 17266442 10334151 17720292
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7116646077
MESH:D012559 Schizophrenia Clozapine 5.6520168265 19369910 17667964 11151749 20580759 17123785 20107430 18806925 18855531 20521326 17726453 16141801 20452607 11763009 20521320
MESH:D012559 Schizophrenia Haloperidol 5.651830565 20107430 18513383 19369910
MESH:D012559 Schizophrenia Risperidone 5.6518278980 19154706 20107430
MESH:D012640 Seizures Dizocilpine Maleate 12.8312660363 17157343 11218047
MESH:D012640 Seizures Lithium 12.8319660546
MESH:D012640 Seizures Phenobarbital 12.834039156 11442880 16876388 3137016
MESH:D012640 Seizures Toluene 12.836431079 9294310
MESH:D003294 Seizures, Febrile Phenobarbital 4.566407741
MESH:D012871 Skin Diseases Mustard Gas 2.6515451306 12880345 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9216192470
MESH:D012893 Sleep Disorders Risperidone 5.2418278980
MESH:D013088 Spermatocele Diethylstilbestrol 10.8216709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8216709447
MESH:D013226 Status Epilepticus Lithium 5.5219570321 19430551 19951488
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8517007042
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.1520210726
MESH:D017180 Tachycardia, Ventricular Risperidone 10.1520210726
MESH:D013733 Testicular Diseases Toluene 4.6910048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.5619014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.561399818
MESH:D013978 Tibial Fractures Estradiol 4.4219048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D005879 Tourette Syndrome Risperidone 5.6819154706
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.9111780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 4.9116452187 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.6416690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.6414692618
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1816513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020301 Vasospasm, Intracranial Nicardipine 5.9819057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D015430 Weight Gain Clozapine 9.6517502770 16141801 20107430 20521320 20564506 16402076
MESH:D015430 Weight Gain Risperidone 9.6520564506 16379507
MESH:D015431 Weight Loss Clozapine 4.8117933447
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04722 Neurotrophin signaling pathway
REACT:15295 Opioid Signalling
KEGG:04380 Osteoclast differentiation
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA26050
    • Releated gene ID Related gene Name
    PA134CYP11B2
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07664 - 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
    DB07676 - 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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