AutismKB 2.0

Annotation Detail for GRINL1A


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Basic Information Top
Gene Symbol:GRINL1A ( DKFZp586F1918 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
Band: 15q22.1
Quick LinksEntrez ID:81488; OMIM: 606485; Uniprot ID:GCOM1_HUMAN; ENSEMBL ID: ENSG00000137878; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GRINL1A mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRINL1A mRNAaffects expression 16483693
C025299 polyphenols polyphenols results in decreased expression of GRINL1A mRNAdecreases expression 16293270
D012643 Selenium Selenium results in decreased expression of GRINL1A mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRINL1A mRNAincreases expression 18796159
C025643 vinclozolin vinclozolin affects the expression of GRINL1A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 10.077525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.0711752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7914694615
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003110 Colonic Neoplasms polyphenols 2.7116293270
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 10.1515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.1514669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.6921346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 9.6919370779
MESH:D056486 Drug-Induced Liver Injury Selenium 9.6915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.6920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 18606429 16354765 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007249 Inflammation polyphenols 5.6316366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6312878042 12200463
MESH:D007251 Influenza, Human Selenium 4.7216624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases polyphenols 2.8416698588
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.4014694615
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0811896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.0819015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.7717997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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