AutismKB 2.0

Annotation Detail for CAMK2A


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Basic Information Top
Gene Symbol:CAMK2A ( CAMKA,KIAA0968 )
Gene Full Name: calcium/calmodulin-dependent protein kinase II alpha
Band: 5q32
Quick LinksEntrez ID:815; OMIM: 114078; Uniprot ID:KCC2A_HUMAN; ENSEMBL ID: ENSG00000070808; HGNC ID: 1460
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa05214Glioma
hsa04740Olfactory transduction
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200189FGF signaling pathway
200016Noncanonical Wnt signaling pathway
200074Netrin-mediated signaling
200110IFN-gamma pathway
200195TGF-beta receptor signaling
Pathway IDPathway Name
P00037Ionotropic glutamate receptor pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1740Alzheimer's disease
1779Cervical cancer
1907Depression
2045Bipolar disorder
2069Schizophrenia
2251Osteosarcoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CAMK2A mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of CAMK2A mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of CAMK2A mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CAMK2A mRNAaffects expression 16483693
D003024 Clozapine Clozapine results in decreased expression of CAMK2A mRNAdecreases expression 17266109
D003024 Clozapine Clozapine results in increased expression of CAMK2A mRNAincreases expression 17266109
D003024 Clozapine Clozapine results in decreased expression of CAMK2A proteindecreases expression 19289156
D003024 Clozapine Clozapine results in increased expression of CAMK2A mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]decreases reaction|increases activity 11073891
C010902 decabromobiphenyl ether decabromobiphenyl ether metabolite results in increased expression of CAMK2A proteinincreases expression 19380496
D004054 Diethylstilbestrol Diethylstilbestrol promotes the reaction [CAMK2A protein results in increased phosphorylation of CAMK2A protein]increases phosphorylation|increases reaction 17184923
D004054 Diethylstilbestrol Diethylstilbestrol results in increased activity of CAMK2A proteinincreases activity 17184923
D004533 Egtazic Acid Egtazic Acid inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]decreases reaction|increases phosphorylation 11073891
D004958 Estradiol Estradiol results in increased expression of CAMK2A mRNAincreases expression 20068009
D006220 Haloperidol Haloperidol results in decreased expression of CAMK2A proteindecreases expression 19289156
D006220 Haloperidol Haloperidol results in increased expression of CAMK2A mRNAincreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of CAMK2A mRNAincreases expression 16807920
C063302 KN 62 KN 62 inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]decreases reaction|increases activity 11073891
D009529 Nicardipine Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]decreases reaction|increases activity 11073891
D009529 Nicardipine Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]decreases reaction|increases phosphorylation 11073891
D010622 Phencyclidine Phencyclidine results in decreased expression of CAMK2A mRNAdecreases expression 17266109
D010622 Phencyclidine Phencyclidine results in increased expression of CAMK2A mRNAincreases expression 17266109
D010656 Phenylephrine Phenylephrine results in decreased expression of CAMK2A mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CAMK2A mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of CAMK2A mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of CAMK2A mRNAdecreases expression 17950772
D018967 Risperidone Risperidone results in decreased expression of CAMK2A proteindecreases expression 19289156
D014700 Verapamil Verapamil inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]decreases reaction|increases activity 11073891
D014700 Verapamil Verapamil inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]decreases reaction|increases phosphorylation 11073891
C025643 vinclozolin vinclozolin affects the expression of CAMK2A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma Estradiol 2.0811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000380 Agranulocytosis Clozapine 4.9714617031 16160616 12649775
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3915469931
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5719015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 8.8820041841 18218290 18057881
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 8.8817460149
MESH:D020817 Asperger Syndrome Risperidone 5.4316401163
MESH:D001281 Atrial Fibrillation Amiodarone 3.8419698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.7318349709
MESH:D001321 Autistic Disorder Acetaminophen 2.3818445737
MESH:D001321 Autistic Disorder Haloperidol 2.3819368416 18080171
MESH:D001321 Autistic Disorder Risperidone 2.3817019624 17069546 16948927 18080171 15492353 16730335 15994720 18775368 19154706 19013209 17929164 16601648 19232924 15543515 18278980 15930063 18349709 18026891 19368416 16239862 16379507
MESH:D001714 Bipolar Disorder Risperidone 4.4718278980 19154706
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.8119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.8119483382
MESH:D001919 Bradycardia Phenylephrine 4.4615306635
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2917129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 2.2917289903 19861407 12948864 14630087 16675129 17018787 18497071 17261762
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.493084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.4915948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4916924424
MESH:D006332 Cardiomegaly Phenylephrine 3.4811754973 11179087 16170337 15728586 17287366 17124262
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8615710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0018974383
MESH:D002375 Catalepsy Haloperidol 4.8215215559 1977408
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.3712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.3718566989
MESH:D002779 Cholestasis Cyclosporine 7.5419486331
MESH:D002779 Cholestasis pirinixic acid 7.5419176532
MESH:D003072 Cognition Disorders Clozapine 4.8817123785
MESH:D003456 Cryptorchidism Diethylstilbestrol 11.0812952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 11.0814966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.1820210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 11.1820210726
MESH:D003704 Dementia Haloperidol 10.2711575062
MESH:D003704 Dementia Risperidone 10.2711575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9516402076
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 14.1715331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 14.1716379507
MESH:D053207 Diurnal Enuresis Risperidone 6.5917822346
MESH:D004314 Down Syndrome Risperidone 5.0018349709
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7916177239 12958197 18713872 14986274 16109766 11421492 11739529 11834606 11287661 16227642 19085960 12392966 14725611 16081117 10915739 15619225 19739265 19420014 15968718 17522070 19416960 19923254 11461765 12153990 18071297 12540782 16781746 14550746 11743745 19370779 17906064 17562736 12705907 19164858 10774834 16485898 10663392 2444490 16393943 12594235 11529661
MESH:D056486 Drug-Induced Liver Injury Amiodarone 3.7915265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:D050171 Dyslipidemias Clozapine 4.1216402076
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.6116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.3515700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.3519148513 11473722 18566989
MESH:D005234 Fatty Liver Amiodarone 12.6214986274
MESH:D005234 Fatty Liver Cyclosporine 12.6219224547
MESH:D005234 Fatty Liver pirinixic acid 12.6219236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.6016513791 16611131 16002989 16534752 15751030
MESH:D005355 Fibrosis Cyclosporine 3.0612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2216417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8616452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006529 Hepatomegaly Amiodarone 8.2915265979
MESH:D006529 Hepatomegaly pirinixic acid 8.2919176532 16221962 19772884 18467677
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.798137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 9.3920558911
MESH:D006943 Hyperglycemia Risperidone 9.3918278980
MESH:D006948 Hyperkinesis Clozapine 4.8216046005
MESH:D006965 Hyperplasia Diethylstilbestrol 4.3514722030 12960047
MESH:D006973 Hypertension Cyclosporine 8.7110903974
MESH:D006973 Hypertension Phenylephrine 8.718949925 12717712
MESH:D006973 Hypertension Verapamil 8.7117700361
MESH:D006984 Hypertrophy Phenylephrine 4.4712791704 18502941
MESH:D007021 Hypospadias Diethylstilbestrol 4.4916002989
MESH:D007037 Hypothyroidism Amiodarone 4.4317991464 18020914
MESH:D007246 Infertility Diethylstilbestrol 4.2715036965
MESH:D007248 Infertility, Male vinclozolin 2.9816467254
MESH:D007333 Insulin Resistance Estradiol 7.0016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.0016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.688314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.6815618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.0012371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.0016762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 12.0015610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9717184923
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6516417039
MESH:D008064 Lipidoses Amiodarone 8.0017567588 15342952
MESH:D008064 Lipidoses Clozapine 8.0017567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2715474484
MESH:D008107 Liver Diseases Acetaminophen 1.6116611625 16610002 12587719 19784758 12969438 19014921 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.4816712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 4.4815890375 20007298 16377806
MESH:D008133 Long QT Syndrome Amiodarone 3.5117391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4018516814
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0615166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4316002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5016891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D001523 Mental Disorders Clozapine 12.9716856516
MESH:D001523 Mental Disorders Haloperidol 12.9716856516
MESH:D001523 Mental Disorders Risperidone 12.9716596465 16856516
MESH:D008607 Mental Retardation Risperidone 4.0818349709
MESH:D024821 Metabolic Syndrome X Clozapine 9.9419142101
MESH:D024821 Metabolic Syndrome X Risperidone 9.9419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D019964 Mood Disorders Risperidone 5.7417019624
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009181 Mycoses Amiodarone 4.8217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.0216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.0216411023
MESH:D009369 Neoplasms Diethylstilbestrol 4.9015313581
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.5211399458
MESH:D009421 Nervous System Malformations Estradiol 9.5216427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D053206 Nocturnal Enuresis Risperidone 6.2517822346
MESH:D009765 Obesity Clozapine 4.6318515891 19142110
MESH:D009765 Obesity pirinixic acid 4.6320558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5815687265 16977796
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.5417184923
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.5418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3617136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 3.3616740699
MESH:D011472 Prostatitis vinclozolin 4.8518629315
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.8711575062
MESH:D011618 Psychotic Disorders Clozapine 8.9415331141
MESH:D011618 Psychotic Disorders Haloperidol 8.9411575062
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8211597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012559 Schizophrenia Clozapine 5.8318806925 19369910 11763009 17123785 20521326 16141801 17667964 20521320 20168265 11151749 20452607 18855531 17726453 20107430 20580759
MESH:D012559 Schizophrenia Haloperidol 5.8320107430 19369910 18513383 1830565
MESH:D012559 Schizophrenia Risperidone 5.8320107430 18278980 19154706
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0018724381
MESH:D012852 Sinusitis Phenylephrine 4.627327846
MESH:D012893 Sleep Disorders Risperidone 5.4218278980
MESH:D013088 Spermatocele Diethylstilbestrol 4.6316002989 16709447
MESH:D013276 Stomach Ulcer Amiodarone 3.2418087811
MESH:D013610 Tachycardia Amiodarone 4.2011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 17.0219225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 17.0220210726
MESH:D017180 Tachycardia, Ventricular Risperidone 17.0220210726
MESH:D013959 Thyroid Diseases Amiodarone 4.6819731979
MESH:D013971 Thyrotoxicosis Amiodarone 4.7718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D016171 Torsades de Pointes Amiodarone 4.1117467628 11989578
MESH:D005879 Tourette Syndrome Risperidone 5.8519154706
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.7416712894 17306315 16452187
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9516175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9816690809 15809267
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3516002989 16513791
MESH:D020301 Vasospasm, Intracranial Nicardipine 6.1619057314
MESH:D015430 Weight Gain Clozapine 10.1220521320 20107430 17502770 16141801 20564506 16402076
MESH:D015430 Weight Gain Risperidone 10.1220564506 16379507
MESH:D015431 Weight Loss Clozapine 4.9917933447
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04012 ErbB signaling pathway
KEGG:04971 Gastric acid secretion
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:04722 Neurotrophin signaling pathway
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
REACT:6900 Signaling in Immune system
REACT:13685 Synaptic Transmission
KEGG:05152 Tuberculosis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04119 - Hexatantalum Dodecabromide
DB04447 - 1,4-Dithiothreitol
DB07766 - (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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