AutismKB 2.0

Annotation Detail for RND2


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Basic Information Top
Gene Symbol:RND2 ( ARHN,RHO7,RhoN )
Gene Full Name: Rho family GTPase 2
Band: 17q21.31
Quick LinksEntrez ID:8153; OMIM: 601555; Uniprot ID:RND2_HUMAN; ENSEMBL ID: ENSG00000108830; HGNC ID: 18315
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RND2 mRNAaffects expression 21346803
D001241 Aspirin Aspirin results in increased expression of RND2 mRNAincreases expression 11906190
D005419 Flavonoids Flavonoids results in decreased expression of RND2 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of RND2 mRNAincreases expression 16101138
C006253 pirinixic acid pirinixic acid results in increased expression of RND2 mRNAincreases expression 17426115
D013629 Tamoxifen Tamoxifen results in decreased expression of RND2 mRNAdecreases expression 15590111
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RND2 mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Fluorouracil 9.5817963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.5811748828
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9320485159 12372130
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001932 Brain Neoplasms Aspirin 4.6815481559
MESH:D001943 Breast Neoplasms Aspirin 2.0215161893
MESH:D001943 Breast Neoplasms Fluorouracil 2.0218608205 18357371 16595493 15136595 19217205 16557594 16110121
MESH:D001943 Breast Neoplasms Tamoxifen 2.0219288272 15668708 19084267 11161223 16818667 19142967 19244106 19059307 18984771 15565566 20065188 20135344 19189210 19155303 19066611 16202921 21152245 19103187 17440819 18351453 19487384 19115204 17049068 16273361 17261762 18855134 18815881 18629630 20544844 19221464 19200415 19011961 18821012 18997820 21138602 17893378 19289846 19410462 17242785 19189212 20390343 20005174 16873071 18425577 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 8.9417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8116705839
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8118930000 17971768 16332177 17045692 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8116924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5518986760 16757204 16280240 17066447
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015668235 15340226 12621046 16354765 8697196
MESH:D003110 Colonic Neoplasms Aspirin 4.2512411196
MESH:D003110 Colonic Neoplasms Fluorouracil 4.2515001691 17018589 17725105 18772588 16510598 17287894 17169374 17016597 17172411 16340194
MESH:D015179 Colorectal Neoplasms Aspirin 2.9217047198
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.9218802399 17255274 16391804 17594712 16303861 18949393 17695437 17016601 18509181 18288408 16524972 14970324 18448328 15289873 20501625 17094418 15148649 18383874 16331619 17401013 17454858 16282729
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3718551238
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Aspirin 13.2017259670
MESH:D004487 Edema pirinixic acid 13.2012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2116202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5016481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver pirinixic acid 8.6319236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 8.6319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005909 Glioblastoma Aspirin 4.1212870263
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006261 Headache Aspirin 5.4015240983
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5615162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4812621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4916959395 18606429 8697196 16354765 15340226
MESH:D012001 Hyperacusis Aspirin 6.2115240983
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007249 Inflammation Flavonoids 9.0717296493
MESH:D007249 Inflammation Tamoxifen 9.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0712878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.8516705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.8516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8518625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms Fluorouracil 11.4318383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 11.4320007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.4316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Fluorouracil 3.5415246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5411884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 19196722 16827153 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008881 Migraine Disorders Aspirin 4.2615240983
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8416757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction Aspirin 6.2612692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009325 Nausea Aspirin 5.6615240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2518551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Fluorouracil 5.3918239605 16928823 18600527
MESH:D009369 Neoplasms pirinixic acid 5.3917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19200415 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6916049721 12819281
MESH:D010003 Osteoarthritis Aspirin 4.217009135
MESH:D010146 Pain Aspirin 4.086995502 6363464
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416929163 15113037 19003803 16500647
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.9411156591
MESH:D020795 Photophobia Aspirin 6.2115240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2319082440 18626508
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2315067354
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2618722050 16160472 18286688 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012220 Rhinitis Aspirin 4.6412372130
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7118551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6212269725
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017172411 17522103 19084572 16951190 17498489 19015929 15786421 16424979 18567086 18396642
MESH:D020521 Stroke Aspirin 4.6016403987
MESH:D013927 Thrombosis Aspirin 4.7617672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3416049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3417572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Aspirin 4.7410982225 20485159
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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