AutismKB 2.0

Annotation Detail for MAGED4B


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Basic Information Top
Gene Symbol:MAGED4B ( KIAA1859,MGC3210,MGC88639 )
Gene Full Name: melanoma antigen family D, 4B
Band: Xp11.22
Quick LinksEntrez ID:81557; OMIM: 300765; Uniprot ID:MAGD4_HUMAN; ENSEMBL ID: ENSG00000187243; HGNC ID: 22880
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of MAGED4B mRNAincreases expression 19774075
D003520 Cyclophosphamide MAGED4B protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D005472 Fluorouracil MAGED4B protein affects the susceptibility to Fluorouracilaffects response to substance 16217747
D008942 Mitoxantrone MAGED4B protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.5017638652
MESH:D000740 Anemia Fluorouracil 4.1117963324 16511603 15504547
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018057881 18218290 20041841
MESH:D001161 Arteriosclerosis Cyclophosphamide 5.1615014928
MESH:D001281 Atrial Fibrillation Amiodarone 4.2018651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.3219483382
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.4917020986 11325840 15136595 17388661 15093573 18234424 18323546 12006526 16978400
MESH:D001943 Breast Neoplasms Fluorouracil 2.4916595493 19217205 18608205 15136595 16557594 16110121 18357371
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.5419701751
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.5417088986 17045692 18930000 16332177 16799960 17971768
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.5216152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 7.3316201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 7.3318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5816280240 16757204 17066447 18986760
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0019225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817725105 17287894 15001691 16340194 16510598 18772588 17018589 17172411 17016597 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015289873 16524972 17594712 17401013 17016601 18509181 17255274 17695437 16331619 16282729 17094418 16303861 14970324 18802399 18448328 18383874 18288408 20501625 18949393 15148649 16391804 17454858
MESH:D003556 Cystitis Cyclophosphamide 5.7115276878 16651033 18433785 17979934 16614059 10700343 15643279 11948286 10498854 18483878 12913760 12388444 18093676 16989017 16413132 18295254 18710439 18372110 12161096 17010015
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.4110990075 11751995 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.3118772604
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4715265979 18218290
MESH:D004802 Eosinophilia Cyclophosphamide 4.7711006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216337965 16785472 15173087 16481741 17638652
MESH:D005234 Fatty Liver Amiodarone 3.9414986274
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D018316 Gliosarcoma Cyclophosphamide 6.1511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.6011014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6418337622 15162350 15102660
MESH:D006331 Heart Diseases Mitoxantrone 4.4116019553
MESH:D006467 Hemophilia A Cyclophosphamide 5.8511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 6.2614986274
MESH:D006529 Hepatomegaly Amiodarone 4.3115265979
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.1517606976 16135485
MESH:D006937 Hypercholesterolemia Amiodarone 4.309751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 5.0817991464 18020914
MESH:D007154 Immune System Diseases Cyclophosphamide 6.0516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.8716517039 7193160
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D007938 Leukemia Cyclophosphamide 3.6610602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 7.4317008537 17802794 18587576 17658394 18172266 17296974
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 7.4318172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.3810373061
MESH:D007970 Leukopenia Cyclophosphamide 5.6010052129 11830472
MESH:D008064 Lipidoses Amiodarone 3.7915342952 17567588
MESH:D008113 Liver Neoplasms Fluorouracil 2.6015113037 17045692 16603448 18383874
MESH:D008133 Long QT Syndrome Amiodarone 3.8915350150 17391786 11989578
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008175 Lung Neoplasms Fluorouracil 2.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008223 Lymphoma Cyclophosphamide 4.1112854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 5.0616675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.5111911406
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.3616388313
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9418986760 16757204
MESH:D009181 Mycoses Amiodarone 5.6217974566 12754197
MESH:D009369 Neoplasms Cyclophosphamide 9.5518854779
MESH:D009369 Neoplasms Fluorouracil 9.5518600527 18239605 16928823
MESH:D009369 Neoplasms Mitoxantrone 9.5516640825
MESH:D009447 Neuroblastoma Cyclophosphamide 3.8116115947 15176712 8761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.528761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D009503 Neutropenia Cyclophosphamide 4.798291058
MESH:D009845 Oligospermia Cyclophosphamide 5.3416517039
MESH:D010146 Pain Cyclophosphamide 3.9618093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.9911332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.9915113037 16929163 19003803 16500647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 4.0021297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.5017136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5019082440 18626508
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.3912490602 12832656 11597910
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 6.3916636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3815538739 18286688 18722050 16160472
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.2816636934
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 6.1516517039
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019084572 17522103 16951190 16424979 17172411 18567086 17498489 18396642 15786421 19015929
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.6912837982
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D013959 Thyroid Diseases Amiodarone 5.4819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.4218020914 19584973
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D016171 Torsades de Pointes Amiodarone 4.8217467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 3.2614692829
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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