AutismKB 2.0

Annotation Detail for PLA2G12A


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Basic Information Top
Gene Symbol:PLA2G12A ( GXII,PLA2G12,ROSSY )
Gene Full Name: phospholipase A2, group XIIA
Band: 4q25
Quick LinksEntrez ID:81579; OMIM: 611652; Uniprot ID:PG12A_HUMAN; ENSEMBL ID: ENSG00000123739; HGNC ID: 18554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
LIPASYN-PWYphospholipases
Pathway IDPathway Name
hsa00565Ether lipid metabolism
hsa00564Glycerophospholipid metabolism
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04010MAPK signaling pathway
hsa00590Arachidonic acid metabolism
hsa05145Toxoplasmosis
hsa04730Long-term depression
hsa04972Pancreatic secretion
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa00591Linoleic acid metabolism
hsa04370VEGF signaling pathway
hsa04664Fc epsilon RI signaling pathway
No data
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl 2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PLA2G12A mRNAincreases expression 20005886
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PLA2G12A mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PLA2G12A mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PLA2G12A mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of PLA2G12A mRNAincreases expression 17202762
C030123 coumarin coumarin results in increased expression of PLA2G12A mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in increased expression of PLA2G12A mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of PLA2G12A mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of PLA2G12A mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLA2G12A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of PLA2G12A mRNAincreases expression 19270015
19482888
C006253 pirinixic acid pirinixic acid results in increased expression of PLA2G12A mRNAincreases expression 18445702
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of PLA2G12A mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of PLA2G12A mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PLA2G12A mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PLA2G12A mRNAincreases expression 20005886
18796159
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of PLA2G12A mRNAincreases expression 17982090
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of PLA2G12A mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of PLA2G12A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5711752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.7917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.627296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.623084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.621701930 17173139 20007298 20935162 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.366135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.367505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.3612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.6219486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 8697196 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 10.0517936198
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 10.0518200517 16474422 17991707 16782535 17936198 18023891 11698051 16804969 16867261
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4617276891
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8711906362 12868966 2524372 8156756 8970840 14531868 11298694 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.6319647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6317107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.1721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.171440618 16192314 18289764 18648102 18692083 11289319 9328219 6482804 8291058 9022650 6679447 9653073 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1710774834 15619225 11743745 14725611 11529661 12594235 17906064 19164858 10663392 16781746 19420014 16109766 17562736 11421492 14550746 16227642 16393943 10915739 12153990 11834606 18713872 19923254 11739529 19416960 19370779 14986274 12392966 11287661 12705907 19739265 16485898 19085960 18071297 15968718 12540782 11461765 12958197 2444490 16177239 16081117 17522070
MESH:D056486 Drug-Induced Liver Injury Selenium 12.1715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 13.3819224547
MESH:D005234 Fatty Liver Dietary Fats 13.3817967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver pirinixic acid 13.3819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis Cyclosporine 21.8212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 21.8218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.8220067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 21.8217994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006333 Heart Failure pirinixic acid 7.0620558911
MESH:D006333 Heart Failure Selenium 7.0617162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.586705139
MESH:D006529 Hepatomegaly Phenobarbital 14.8216109766
MESH:D006529 Hepatomegaly pirinixic acid 14.8219176532 18467677 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.8215340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.0714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416959395 8697196 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5918200517
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance Dietary Fats 7.3618457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.3616306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.6817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.1818776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.1812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.636582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7621047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4416169303
MESH:D008107 Liver Diseases Acetaminophen 3.9719014921 19784758 12969438 16610002 16611625 12587719 19460945 11587558
MESH:D008107 Liver Diseases Phenobarbital 3.9719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2916871587 17185352
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 14.4718644402 16835634
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.477678174
MESH:D008113 Liver Neoplasms Phenobarbital 14.4719812893 19482888 8742319 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 14.4720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.382876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.38598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.3818308698 6150874 17172636 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.3812151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3211062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 5.458820588
MESH:D009369 Neoplasms pirinixic acid 5.4517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Dietary Fats 4.4718674790 11836018 16723640 21332399 18457598 20132043 19632207 17217161 20518802
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.054026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.2617698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1312371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.132563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3015084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0518551238
MESH:D012640 Seizures Phenobarbital 6.053137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.286587162 3712494 6582329 1399818 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.281399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.078074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014689 Venous Insufficiency coumarin 5.8712708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:00592 alpha-Linolenic acid metabolism
KEGG:00590 Arachidonic acid metabolism
KEGG:00565 Ether lipid metabolism
KEGG:04975 Fat digestion and absorption
KEGG:04664 Fc epsilon RI signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:00564 Glycerophospholipid metabolism
KEGG:04912 GnRH signaling pathway
KEGG:00591 Linoleic acid metabolism
KEGG:04730 Long-term depression
KEGG:04010 MAPK signaling pathway
KEGG:01100 Metabolic pathways
KEGG:04972 Pancreatic secretion
KEGG:05145 Toxoplasmosis
KEGG:04270 Vascular smooth muscle contraction
KEGG:04370 VEGF signaling pathway
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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