AutismKB 2.0

Annotation Detail for CAMK2B


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Basic Information Top
Gene Symbol:CAMK2B ( CAM2,CAMK2,CAMKB,MGC29528 )
Gene Full Name: calcium/calmodulin-dependent protein kinase II beta
Band: 7p13
Quick LinksEntrez ID:816; OMIM: 607707; Uniprot ID:KCC2B_HUMAN; ENSEMBL ID: ENSG00000058404; HGNC ID: 1461
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa05214Glioma
hsa04740Olfactory transduction
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200014p38 MAPK signaling pathway
200110IFN-gamma pathway
Pathway IDPathway Name
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
1907Depression
2069Schizophrenia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CAMK2B mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of CAMK2B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CAMK2B mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of CAMK2B mRNAincreases expression 17603807
D002794 Choline Choline affects the expression of CAMK2B mRNAaffects expression 17264169
D002794 Choline Choline affects the expression of CAMK2B proteinaffects expression 17264169
D003024 Clozapine Clozapine results in decreased expression of CAMK2B mRNAdecreases expression 15860345
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CAMK2B mRNAincreases expression 17942748
D006220 Haloperidol Haloperidol results in decreased expression of CAMK2B mRNAdecreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of CAMK2B mRNAincreases expression 16807920
D008713 Methimazole Methimazole results in decreased expression of CAMK2B mRNAdecreases expression 17403546
D008713 Methimazole Methimazole results in increased expression of CAMK2B mRNAincreases expression 17403546
D009151 Mustard Gas Mustard Gas results in increased expression of CAMK2B mRNAincreases expression 15674844
D017239 Paclitaxel CAMK2B protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C494474 perchlorate perchlorate results in decreased expression of CAMK2B mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in increased expression of CAMK2B mRNAincreases expression 17403546
C006253 pirinixic acid pirinixic acid results in increased expression of CAMK2B mRNAincreases expression 18445702
D011441 Propylthiouracil Propylthiouracil results in decreased expression of CAMK2B mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in increased expression of CAMK2B mRNAincreases expression 17403546
D012643 Selenium Selenium results in increased expression of CAMK2B mRNAincreases expression 19244175
C025643 vinclozolin vinclozolin affects the expression of CAMK2B mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of CAMK2B mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.733712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4416434500
MESH:D000380 Agranulocytosis Clozapine 5.0216160616 12649775 14617031
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001249 Asthma Mustard Gas 2.7010378619
MESH:D001321 Autistic Disorder Acetaminophen 2.3818445737
MESH:D001321 Autistic Disorder Choline 2.3816818868
MESH:D001321 Autistic Disorder Haloperidol 2.3818080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001768 Blister Mustard Gas 5.1219167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 9.0819483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.5315867366
MESH:D001943 Breast Neoplasms Paclitaxel 2.9316115903 18234424 11325840 18223236 15136595 16273361 18323546 16244791
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9517687719 10378619
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8916050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.573581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.573084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.5716313753
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.657296757
MESH:D002375 Catalepsy Haloperidol 4.8715215559 1977408
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.737505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.189022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.1816105132 15861022 17681005 17110522 16919318 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 13.1819176532
MESH:D003072 Cognition Disorders Clozapine 4.9217123785
MESH:D003092 Colitis Selenium 3.7417936198
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003456 Cryptorchidism vinclozolin 4.3014966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8020210726
MESH:D003704 Dementia Haloperidol 4.5411575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 11906362 18759878 14531868 8156756 2524372 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D002658 Developmental Disabilities Choline 4.6416818868
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9616402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5315331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.121440618 8291058 11289319 18289764 18648102 9022650 6482804 18692083 9328219 7440962 9653073 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1219085960 11739529 19739265 19416960 11287661 11461765 16081117 11743745 18071297 12153990 10915739 14725611 16109766 18713872 17906064 12540782 16177239 16781746 12705907 19923254 15968718 11834606 17522070 17562736 12392966 10774834 16393943 11529661 11421492 19164858 15619225 14550746 10663392 16227642 19420014 14986274 16485898 19370779 12958197 2444490 12594235
MESH:D056486 Drug-Induced Liver Injury Selenium 6.1215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D050171 Dyslipidemias Clozapine 4.1516402076
MESH:C538011 Eales disease Vitamin E 4.689068938
MESH:D004487 Edema Mustard Gas 6.7511428647 11402378 11428631 9260866
MESH:D004487 Edema pirinixic acid 6.7512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004890 Erythema Mustard Gas 5.129357497
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.653581430
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.6516481741
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4115345470
MESH:D005234 Fatty Liver pirinixic acid 7.4120131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2716417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 11.347505956
MESH:D006042 Goiter perchlorate 11.3418801409
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9616080930
MESH:D006333 Heart Failure pirinixic acid 6.8620558911
MESH:D006333 Heart Failure Selenium 6.8617162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006529 Hepatomegaly pirinixic acid 2.9616221962 19176532 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.9414716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006948 Hyperkinesis Clozapine 4.8716046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006980 Hyperthyroidism Methimazole 5.5714678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007037 Hypothyroidism Methimazole 11.8218031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.828137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5617937319
MESH:D007248 Infertility, Male vinclozolin 6.5616467254
MESH:D007249 Inflammation Mustard Gas 2.7617524151 16001271 8975870 11428647 9357497 11428620 11428631 11402378 9260866
MESH:D007251 Influenza, Human Selenium 10.8616624496
MESH:D007251 Influenza, Human Vitamin E 10.8616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 5.8815629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 5.8812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8416518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.936582329
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7016417039
MESH:D008064 Lipidoses Clozapine 3.9317567588
MESH:D008080 Liposarcoma Paclitaxel 4.7817353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3616169303
MESH:D008107 Liver Diseases Acetaminophen 1.6219784758 16611625 11587558 12969438 16610002 19014921 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 1.8015890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.501399818 6587162 598648 3712494
MESH:D008171 Lung Diseases Mustard Gas 7.4418161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.4416863852
MESH:D008175 Lung Neoplasms Mustard Gas 2.633148597 8781369
MESH:D008175 Lung Neoplasms Vitamin E 2.6311062179
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0514749477
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7315318939
MESH:D008545 Melanoma Paclitaxel 2.5816342250 12040289 12025231
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D001523 Mental Disorders Clozapine 8.2516856516
MESH:D001523 Mental Disorders Haloperidol 8.2516856516
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D024821 Metabolic Syndrome X Clozapine 4.3719142101
MESH:D009041 Motion Sickness Dextroamphetamine 5.491613127
MESH:D009101 Multiple Myeloma Paclitaxel 3.6514749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.903581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.9015867366
MESH:D009369 Neoplasms pirinixic acid 1.9317405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.886679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D009503 Neutropenia Mustard Gas 3.9316761898 7688884
MESH:D009765 Obesity Clozapine 4.6718515891 19142110
MESH:D009765 Obesity pirinixic acid 4.6720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010014 Osteolysis Paclitaxel 4.9415867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 2.9811161223
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D010954 Plasmacytoma Selenium 4.8615087411
MESH:D011041 Poisoning Mustard Gas 3.7615727166
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.8618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9018220299
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5317136230 16356831 16729912 17172428
MESH:D011471 Prostatic Neoplasms Vitamin E 3.5315084515
MESH:D011472 Prostatitis vinclozolin 4.9018629315
MESH:D011537 Pruritus Ethinyl Estradiol 9.4116919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.4118058305
MESH:D011595 Psychomotor Agitation Haloperidol 4.9211575062
MESH:D011605 Psychoses, Substance-Induced marker/mechanism 17603807
MESH:D011618 Psychotic Disorders Clozapine 9.0515331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0511575062
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9117620002 10334151 17720292 17894541 17266442
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:D012559 Schizophrenia marker/mechanism 20336626 11042361
MESH:D012559 Schizophrenia Clozapine 4.0820521326 20107430 11763009 20452607 11151749 17726453 20521320 18855531 19369910 17667964 18806925 20580759 17123785 20168265 16141801
MESH:D012559 Schizophrenia Haloperidol 4.0819369910 20107430 1830565 18513383
MESH:D012871 Skin Diseases Mustard Gas 4.9916961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 4.9918709164
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418396642 18506536
MESH:D020521 Stroke Vitamin E 3.4816517955
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6720210726
MESH:D024801 Tauopathies Paclitaxel 4.7816930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.266582329 3712494 7505956 1399818 6587162
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.2615710170
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.268074119
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D015430 Weight Gain Clozapine 4.4317502770 20107430 20521320 16141801 16402076 20564506
MESH:D015431 Weight Loss Clozapine 5.0417933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04012 ErbB signaling pathway
KEGG:04971 Gastric acid secretion
KEGG:05214 Glioma
KEGG:04912 GnRH signaling pathway
KEGG:04720 Long-term potentiation
KEGG:04916 Melanogenesis
KEGG:04722 Neurotrophin signaling pathway
KEGG:04740 Olfactory transduction
KEGG:04114 Oocyte meiosis
REACT:6900 Signaling in Immune system
REACT:13685 Synaptic Transmission
KEGG:05152 Tuberculosis
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA91
    • No data
    No data
    Releated drug ID Related drug Name
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA164744376adenosine monophosphate
    PA449396dopamine
    PA164743471adenosine triphosphate
    PA448948chloroquine
    PA449167cyclosporine
    PA451578tacrolimus
    PA151917011valinomycin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB07168 - [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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