AutismKB 2.0

Annotation Detail for TRIM8


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Basic Information Top
Gene Symbol:TRIM8 ( GERP,RNF27 )
Gene Full Name: tripartite motif-containing 8
Band: 10q24.32
Quick LinksEntrez ID:81603; OMIM: 606125; Uniprot ID:TRIM8_HUMAN; ENSEMBL ID: ENSG00000171206; HGNC ID: 15579
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TRIM8 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of TRIM8 mRNAaffects expression 17562736
D001374 Azacitidine Azacitidine results in increased expression of TRIM8 mRNAincreases expression 19194470
C006780 bisphenol A bisphenol A results in increased expression of TRIM8 mRNAincreases expression 20678512
C014347 decitabine decitabine results in increased expression of TRIM8 mRNAincreases expression 19194470
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TRIM8 mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9017123778
MESH:D001943 Breast Neoplasms decitabine 1.9018320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6619215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 12621046 16354765 15340226
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms Azacitidine 2.9619934284
MESH:D015179 Colorectal Neoplasms decitabine 2.9618981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8117522070 18071297 17562736 12540782 16485898 16227642 19370779 17906064 16393943 16781746 12594235 11834606 15619225 15968718 11421492 19416960 10774834 12153990 19420014 14550746 12392966 10663392 2444490 12958197 19923254 14986274 19164858 16177239 16081117 18713872 10915739 19085960 11287661 16109766 19739265 11739529 12705907 11743745 11529661 11461765 14725611
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 16714409 15322242
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3116120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 3.4816393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007938 Leukemia Azacitidine 7.2319148494
MESH:D007938 Leukemia decitabine 7.2319235587 18980019
MESH:D007951 Leukemia, Myeloid Azacitidine 11.0119077051
MESH:D007951 Leukemia, Myeloid decitabine 11.0118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.4618720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.4618460780 18206229 18704418 19387464 17679729 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.5419299654
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16611625 19014921 12587719 19460945 12969438 16610002 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008175 Lung Neoplasms Azacitidine 2.6821224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6819555203 11884234
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009006 Monosomy Azacitidine 6.6019299654
MESH:D009101 Multiple Myeloma Azacitidine 8.4319549372 18443271
MESH:D009101 Multiple Myeloma decitabine 8.4318172295
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.3617596541 17611569 18720364 19805378
MESH:D009190 Myelodysplastic Syndromes decitabine 8.3619010910 18608210 16882708 19157545
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms decitabine 2.8419116145 19470736 17925555
MESH:D009421 Nervous System Malformations bisphenol A 10.8816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.8814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
MESH:D010051 Ovarian Neoplasms decitabine 2.7219331143 19259094
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8519294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 11.1010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.1011222880 11399792 11896295 11118676
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.5320887781
MESH:D011471 Prostatic Neoplasms Azacitidine 3.5918324645
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5916740699
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8219087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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