Annotation Detail for MAP1LC3B
Basic Information Top
| Gene Symbol: | MAP1LC3B ( ATG8F,LC3B,MAP1A/1BLC3 ) |
|---|---|
| Gene Full Name: | microtubule-associated protein 1 light chain 3 beta |
| Band: | 16q24.2 |
| Quick Links | Entrez ID:81631; OMIM: 609604; Uniprot ID:MLP3B_HUMAN; ENSEMBL ID: ENSG00000140941; HGNC ID: 13352 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Pathway Information| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C009505 | 4,4'-diaminodiphenylmethane | 4,4'-diaminodiphenylmethane results in decreased expression of MAP1LC3B mRNA | decreases expression | 18648102 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of MAP1LC3B mRNA | affects expression | 16483693 |
| D015123 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MAP1LC3B mRNA | increases expression | 20382639 19150397 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in increased expression of MAP1LC3B mRNA | increases expression | 15336504 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of MAP1LC3B mRNA | affects expression | 17484886 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of MAP1LC3B mRNA | increases expression | 20106945 |
| C014347 | decitabine | decitabine inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 19577553 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol affects the expression of MAP1LC3B mRNA | affects expression | 17555576 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in decreased expression of MAP1LC3B mRNA | decreases expression | 17942748 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MAP1LC3B mRNA | affects cotreatment|decreases expression | 17942748 |
| D005419 | Flavonoids | Flavonoids results in decreased expression of MAP1LC3B mRNA | decreases expression | 18035473 |
| D005472 | Fluorouracil | MAP1LC3B protein affects the susceptibility to Fluorouracil | affects response to substance | 15548681 |
| D005978 | Glutathione | Glutathione deficiency results in increased expression of MAP1LC3B mRNA | increases expression | 15345336 |
| D017313 | Fenretinide | Fenretinide results in increased expression of MAP1LC3B mRNA | increases expression | 16671099 |
| C005134 | juglone | juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 20479004 |
| D001556 | Lindane | Lindane results in increased expression of MAP1LC3B mRNA | increases expression | 17785943 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in increased expression of MAP1LC3B mRNA | increases expression | 17616710 |
| C093973 | PD 98059 | PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 20479004 |
| C006253 | pirinixic acid | pirinixic acid results in increased expression of MAP1LC3B mRNA | increases expression | 18445702 18301758 |
| C487081 | PXD101 | PXD101 results in increased expression of MAP1LC3B mRNA | increases expression | 19606018 |
| C017947 | sodium arsenite | decitabine inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 19577553 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of MAP1LC3B protein | increases expression | 19577553 |
| C017947 | sodium arsenite | U 0126 inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 19577553 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of MAP1LC3B mRNA | decreases expression | 19072884 |
| D013629 | Tamoxifen | MAP1LC3B protein results in decreased susceptibility to Tamoxifen | decreases response to substance | 20479004 |
| D013629 | Tamoxifen | Tamoxifen affects the expression of MAP1LC3B mRNA | affects expression | 17555576 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of MAP1LC3B mRNA | affects cotreatment|decreases expression | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of MAP1LC3B mRNA | increases expression | 18796159 16054898 18465118 |
| D013755 | Tetradecanoylphorbol Acetate | E2F4 protein promotes the reaction [PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]] | increases expression|increases reaction | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | E2F4 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | increases expression|increases reaction | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | EGR1 protein promotes the reaction [PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]] | increases expression|increases reaction | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | EGR1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | increases expression|increases reaction | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | juglone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | PD 98059 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein] | increases expression|increases reaction | 20479004 |
| D013755 | Tetradecanoylphorbol Acetate | Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein | increases expression | 20479004 |
| C012589 | trichostatin A | trichostatin A results in increased expression of MAP1LC3B mRNA | increases expression | 19606018 |
| C113580 | U 0126 | U 0126 inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3B protein] | decreases reaction|increases expression | 19577553 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000008 | Abdominal Neoplasms | Tamoxifen | 4.38 | 14745880 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 2.68 | 15322242 14514962 11752688 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 3.39 | 18287403 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 3.77 | 17505938 | |
| MESH:D000168 | Acrocephalosyndactylia | U 0126 | 5.30 | 17694057 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 2.96 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 6.94 | 14692618 | |
| MESH:D000230 | Adenocarcinoma | Fenretinide | 6.94 | 10697514 | |
| MESH:D000230 | Adenocarcinoma | Fluorouracil | 6.94 | 17638652 | |
| MESH:D000236 | Adenoma | 4,4'-diaminodiphenylmethane | 2.65 | 3712494 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 9.33 | 16434500 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 9.33 | 16835633 | |
| MESH:D000310 | Adrenal Gland Neoplasms | sodium arsenite | 4.53 | 15276417 | |
| MESH:D018246 | Adrenocortical Adenoma | sodium arsenite | 4.73 | 17306315 16712894 | |
| MESH:D000382 | Agricultural Workers' Diseases | Lindane | 4.20 | 12661182 | |
| MESH:D000740 | Anemia | Fluorouracil | 8.18 | 16511603 17963324 15504547 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 8.18 | 11748828 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 3.29 | 11256880 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 2.56 | 15885639 | |
| MESH:D001321 | Autistic Disorder | Glutathione | 3.03 | 16917939 19267885 19056591 18929414 | |
| MESH:D001660 | Biliary Tract Diseases | 4,4'-diaminodiphenylmethane | 4.85 | 1440618 11289319 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 8.25 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 8.25 | 12125929 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 3.62 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 2.65 | 15746008 | |
| MESH:D001932 | Brain Neoplasms | Fenretinide | 4.20 | 16187019 | |
| MESH:D001943 | Breast Neoplasms | decitabine | 2.89 | 19208741 18320071 | |
| MESH:D001943 | Breast Neoplasms | Fenretinide | 2.89 | 16601279 | |
| MESH:D001943 | Breast Neoplasms | Fluorouracil | 2.89 | 15136595 18357371 19217205 16110121 18608205 16557594 16595493 | |
| MESH:D001943 | Breast Neoplasms | Lindane | 2.89 | 14688026 | |
| MESH:D001943 | Breast Neoplasms | Tamoxifen | 2.89 | 17893378 20544844 19103187 19115204 19288272 20005174 17440819 19155303 18815881 11161223 19221464 19189210 17261762 20135344 19066611 19142967 17049068 19084267 21152245 19289846 19487384 18855134 19200415 18984771 20065188 18629630 18997820 15668708 18821012 16202921 16273361 15565566 21138602 19189212 19059307 19011961 19410462 18351453 20390343 17242785 16873071 18425577 19244106 16818667 20859285 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 2.89 | 20435547 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 3.61 | 16097048 15721981 16227642 16124888 3786805 15700767 18705752 16011737 10355542 15673190 16192424 16050911 | |
| MESH:D002276 | Carcinoid Tumor | Fluorouracil | 4.50 | 16051944 | |
| MESH:D002277 | Carcinoma | Fluorouracil | 7.73 | 17121937 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 7.73 | 16835633 | |
| MESH:D018270 | Carcinoma, Ductal, Breast | Tamoxifen | 4.34 | 19066611 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 4,4'-diaminodiphenylmethane | 11.03 | 3581430 7296757 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 11.03 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fenretinide | 11.03 | 16270382 17159502 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fluorouracil | 11.03 | 18930000 17088986 17971768 17045692 16799960 16332177 | |
| MESH:D006528 | Carcinoma, Hepatocellular | sodium arsenite | 11.03 | 16507464 17306315 15276417 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Tamoxifen | 11.03 | 16924424 | |
| MESH:D002292 | Carcinoma, Renal Cell | 4,4'-diaminodiphenylmethane | 6.23 | 7296757 | |
| MESH:D002292 | Carcinoma, Renal Cell | Fluorouracil | 6.23 | 18695887 | |
| MESH:D002294 | Carcinoma, Squamous Cell | decitabine | 17.45 | 19215824 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fenretinide | 17.45 | 16274795 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fluorouracil | 17.45 | 16280240 18986760 16757204 17066447 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Glutathione | 17.45 | 17015178 | |
| MESH:D002294 | Carcinoma, Squamous Cell | sodium arsenite | 17.45 | 18572023 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Tetradecanoylphorbol Acetate | 17.45 | 18922899 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Tamoxifen | 3.46 | 17572228 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 2.27 | 18850075 16120746 18670907 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 4,4'-diaminodiphenylmethane | 15.05 | 7505956 | |
| MESH:D002471 | Cell Transformation, Neoplastic | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 15.05 | 20889678 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 15.05 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | sodium arsenite | 15.05 | 19524636 20056578 | |
| MESH:D018290 | Cervical Intraepithelial Neoplasia | Fenretinide | 5.30 | 16154183 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 3.02 | 16835633 | |
| MESH:D002779 | Cholestasis | 4,4'-diaminodiphenylmethane | 18.17 | 19486331 9022650 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 18.17 | 19486331 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 18.17 | 17681005 17333356 16919318 16105132 17110522 11677210 15861022 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 18.17 | 19176532 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 2.03 | 12621046 15340226 15668235 8697196 16354765 | |
| MESH:D003110 | Colonic Neoplasms | decitabine | 3.76 | 17616700 | |
| MESH:D003110 | Colonic Neoplasms | Fluorouracil | 3.76 | 15001691 17287894 18772588 17018589 16510598 17016597 17725105 17172411 16340194 17169374 | |
| MESH:D015179 | Colorectal Neoplasms | decitabine | 3.50 | 18981723 | |
| MESH:D015179 | Colorectal Neoplasms | Fenretinide | 3.50 | 17273769 | |
| MESH:D015179 | Colorectal Neoplasms | Fluorouracil | 3.50 | 16282729 18383874 16524972 18949393 20501625 14970324 17695437 15289873 16331619 17016601 18802399 17454858 17401013 18288408 15148649 18448328 18509181 17094418 16391804 16303861 17594712 17255274 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 2.91 | 17141729 14669216 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 1.25 | 15322242 10048152 20055451 | |
| MESH:D003550 | Cystic Fibrosis | Glutathione | 4.34 | 19747007 | |
| MESH:D007644 | Darier Disease | Fluorouracil | 4.62 | 16733453 | |
| MESH:D003711 | Demyelinating Diseases | Tamoxifen | 4.19 | 19031437 | |
| MESH:D017449 | Dermatitis, Allergic Contact | 4,4'-diaminodiphenylmethane | 2.64 | 12868966 8970840 8156756 11298694 2524372 18759878 14531868 11906362 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.35 | 18249437 | |
| MESH:D003877 | Dermatitis, Contact | 4,4'-diaminodiphenylmethane | 3.33 | 2952479 3621924 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 1.63 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Tamoxifen | 3.33 | 19279558 | |
| MESH:D056486 | Drug-Induced Liver Injury | 4,4'-diaminodiphenylmethane | 5.87 | 7440962 18692083 18648102 18289764 9328219 16192314 9653073 11289319 6679447 8291058 6482804 9022650 1440618 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 5.87 | 7179309 16227642 15027814 21278145 19336974 9327722 3786805 10915739 3732212 15968718 15998439 7440962 7120509 16177239 11566570 17522070 4309450 19085960 6623471 2869522 6884620 10092053 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 5.87 | 20420201 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 2.63 | 11462148 | |
| MESH:D004487 | Edema | pirinixic acid | 10.57 | 12083418 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 10.57 | 11000095 12711302 | |
| MESH:D004487 | Edema | Tetradecanoylphorbol Acetate | 10.57 | 8273558 16716910 15177302 11698051 7812673 8113982 9599246 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 3.73 | 18230668 16714409 15322242 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 8.39 | 12538720 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Tamoxifen | 8.39 | 19031437 | |
| MESH:D004701 | Endocrine Gland Neoplasms | decitabine | 13.45 | 19294695 | |
| MESH:D004701 | Endocrine Gland Neoplasms | trichostatin A | 13.45 | 19294695 | |
| MESH:D016889 | Endometrial Neoplasms | Tamoxifen | 2.93 | 16202921 20544844 19155303 17893378 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 2.87 | 9294722 10568697 | |
| MESH:D004938 | Esophageal Neoplasms | 4,4'-diaminodiphenylmethane | 10.05 | 3581430 | |
| MESH:D004938 | Esophageal Neoplasms | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | 10.05 | 20426865 | |
| MESH:D004938 | Esophageal Neoplasms | Fluorouracil | 10.05 | 16481741 15173087 16785472 16337965 17638652 | |
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 10.05 | 15150132 15547733 15878914 15264214 15623463 16510608 15547721 16704527 16805852 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 2.89 | 11564622 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 22.97 | 12795759 16239168 12631006 17595544 15959796 16045604 19224547 61145 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 22.97 | 19224547 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 22.97 | 15345470 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 22.97 | 20131406 19236843 | |
| MESH:D005234 | Fatty Liver | Tamoxifen | 22.97 | 19224547 14986274 | |
| MESH:D052776 | Female Urogenital Diseases | Tamoxifen | 3.13 | 16709447 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 3.29 | 11858732 | |
| MESH:D005350 | Fibroma | 4,4'-diaminodiphenylmethane | 4.85 | 6705139 | |
| MESH:D018221 | Fibromatosis, Abdominal | Tamoxifen | 4.35 | 14745880 | |
| MESH:D018222 | Fibromatosis, Aggressive | Tamoxifen | 4.01 | 19069698 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 13.72 | 18705752 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 13.72 | 12639820 12168785 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 13.72 | 20067830 | |
| MESH:D005833 | Genital Neoplasms, Female | sodium arsenite | 4.51 | 16452187 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 4.05 | 8708960 | |
| MESH:D005909 | Glioblastoma | Fenretinide | 7.38 | 16187019 | |
| MESH:D005909 | Glioblastoma | trichostatin A | 7.38 | 18801729 | |
| MESH:D005910 | Glioma | Fluorouracil | 2.80 | 16145905 | |
| MESH:D006042 | Goiter | 4,4'-diaminodiphenylmethane | 3.88 | 7505956 | |
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 4.42 | 10696789 | |
| MESH:D006258 | Head and Neck Neoplasms | decitabine | 7.52 | 19215824 | |
| MESH:D006258 | Head and Neck Neoplasms | Fluorouracil | 7.52 | 15162350 15102660 18337622 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 2.24 | 11294989 10048152 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.43 | 20558911 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 4.25 | 15720958 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 3.18 | 11000095 | |
| MESH:D006505 | Hepatitis | 4,4'-diaminodiphenylmethane | 8.67 | 6705139 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 8.67 | 19110552 19900420 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 7.70 | 19772884 19176532 18467677 16221962 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 7.70 | 15340226 16120746 12621046 | |
| MESH:D006689 | Hodgkin Disease | sodium arsenite | 3.01 | 12676792 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 3.87 | 16354765 15340226 18606429 8697196 16959395 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 4.36 | 16899240 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.03 | 20558911 | |
| MESH:D006965 | Hyperplasia | 4,4'-diaminodiphenylmethane | 3.77 | 15034207 | |
| MESH:D006973 | Hypertension | Cyclosporine | 4.73 | 10903974 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 4.73 | 18850075 18670907 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 3.92 | 15338365 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 3.64 | 16569931 16945680 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 3.30 | 12013081 | |
| MESH:D007248 | Infertility, Male | decitabine | 10.57 | 17581917 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 10.57 | 17937319 | |
| MESH:D007248 | Infertility, Male | sodium arsenite | 10.57 | 12646999 15346721 | |
| MESH:D007249 | Inflammation | Flavonoids | 11.26 | 17296493 | |
| MESH:D007249 | Inflammation | Tamoxifen | 11.26 | 19457130 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 11.26 | 12878042 12200463 | |
| MESH:D007249 | Inflammation | Tetradecanoylphorbol Acetate | 11.26 | 15177302 7812673 11698051 8273558 7562506 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.52 | 16306350 | |
| MESH:D007565 | Jaundice | 4,4'-diaminodiphenylmethane | 4.85 | 8074119 9022650 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 3.18 | 16580747 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 4.27 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 5.69 | 18776723 10903974 8314463 | |
| MESH:D007674 | Kidney Diseases | sodium arsenite | 5.69 | 20008137 | |
| MESH:D007680 | Kidney Neoplasms | 4,4'-diaminodiphenylmethane | 16.61 | 6582329 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 16.61 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Fluorouracil | 16.61 | 16985049 | |
| MESH:D007680 | Kidney Neoplasms | Tamoxifen | 16.61 | 18625569 | |
| MESH:D007938 | Leukemia | decitabine | 2.99 | 19235587 18980019 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | PD 98059 | 11.51 | 16972261 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | U 0126 | 11.51 | 16972261 | |
| MESH:D007951 | Leukemia, Myeloid | decitabine | 3.85 | 17236224 19117987 18454857 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | decitabine | 4.17 | 19387464 19010910 18206229 17679729 18704418 18460780 | |
| MESH:D015470 | Leukemia, Myeloid, Acute | trichostatin A | 4.17 | 18206229 | |
| MESH:D015477 | Leukemia, Myelomonocytic, Chronic | decitabine | 5.29 | 18055864 | |
| MESH:D007972 | Leukoplakia, Oral | Fenretinide | 5.87 | 16707609 | |
| MESH:D008064 | Lipidoses | Tamoxifen | 3.03 | 17567588 15342952 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 2.71 | 17157831 17174718 11408273 17334410 16943688 21278145 11903743 16221502 16239168 | |
| MESH:D008105 | Liver Cirrhosis, Biliary | 4,4'-diaminodiphenylmethane | 3.09 | 15034207 9327722 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 4.74 | 18263696 12649538 17944888 16248980 15123356 12741479 18205269 15818738 17976157 18472094 18166357 15673190 18481824 12546737 15370692 16015684 18006644 18277467 18054572 15730626 14716833 12586293 17525996 16136751 14724832 12898905 18339082 12632514 16033810 18376398 16116963 17557913 16011737 17761835 12958196 17481882 11481614 18251166 17721639 17714472 17631135 18472332 15052691 17869086 12445421 17823541 12389079 12666154 14512876 18412020 17900296 15338365 13678700 17805973 18317297 18395914 17640975 14748882 14620537 17708605 15650968 18210741 18705752 14716496 10355542 15931870 15959796 16638106 12609069 17922224 15362042 12445418 18429990 18420326 18279442 15057751 20821823 17698563 16027843 18156304 18418968 18187930 16192424 17766677 12667390 12632512 15893842 18395095 17565644 15925388 15876570 15996030 16097048 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 4.74 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tamoxifen | 4.74 | 18564211 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 4.74 | 12878042 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 4.29 | 17285989 16964402 16246199 15830285 15720792 | |
| MESH:D008107 | Liver Diseases | Lindane | 4.29 | 1715830 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 3.99 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 3.54 | 16899240 14706259 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 17.14 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Fluorouracil | 17.14 | 16603448 17045692 15113037 18383874 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 17.14 | 15890375 16377806 20007298 | |
| MESH:D008113 | Liver Neoplasms | sodium arsenite | 17.14 | 16712894 15276417 | |
| MESH:D008113 | Liver Neoplasms | Tamoxifen | 17.14 | 16684651 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 17.14 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | 4,4'-diaminodiphenylmethane | 9.16 | 6587162 3712494 598648 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 9.16 | 12014681 15583823 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 9.16 | 12151625 | |
| MESH:D008171 | Lung Diseases | sodium arsenite | 3.06 | 19095001 | |
| MESH:D008175 | Lung Neoplasms | Fluorouracil | 6.37 | 15246190 | |
| MESH:D008175 | Lung Neoplasms | sodium arsenite | 6.37 | 17306315 15276417 16712894 17077188 19931552 | |
| MESH:D008175 | Lung Neoplasms | Tamoxifen | 6.37 | 18625569 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 6.37 | 11884234 19555203 | |
| MESH:D008175 | Lung Neoplasms | Tetradecanoylphorbol Acetate | 6.37 | 11807781 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Fluorouracil | 4.62 | 15086387 | |
| MESH:D008223 | Lymphoma | decitabine | 3.30 | 19470736 | |
| MESH:D015674 | Mammary Neoplasms, Animal | Tamoxifen | 3.59 | 19428831 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Fenretinide | 9.54 | 10697514 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tamoxifen | 9.54 | 19196723 11731420 19196722 14580682 16827153 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Tetradecanoylphorbol Acetate | 9.54 | 8985016 | |
| MESH:D020149 | Manganese Poisoning | Tamoxifen | 4.38 | 19453300 | |
| MESH:D008545 | Melanoma | decitabine | 9.49 | 16505122 17785578 | |
| MESH:D008545 | Melanoma | Fenretinide | 9.49 | 16270382 | |
| MESH:D008545 | Melanoma | sodium arsenite | 9.49 | 16487513 19082730 | |
| MESH:D008545 | Melanoma | Tamoxifen | 9.49 | 19393235 12393984 | |
| MESH:D008545 | Melanoma | trichostatin A | 9.49 | 16505122 | |
| MESH:D018328 | Melanoma, Amelanotic | Tamoxifen | 4.01 | 15990972 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 4.62 | 16801185 | |
| MESH:D009062 | Mouth Neoplasms | Fenretinide | 8.51 | 16274795 | |
| MESH:D009062 | Mouth Neoplasms | Fluorouracil | 8.51 | 18986760 16757204 | |
| MESH:D009101 | Multiple Myeloma | decitabine | 7.25 | 18172295 | |
| MESH:D009101 | Multiple Myeloma | trichostatin A | 7.25 | 18172295 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 3.34 | 16239165 | |
| MESH:D009190 | Myelodysplastic Syndromes | decitabine | 3.29 | 19157545 18608210 19010910 16882708 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.07 | 19151258 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 2.88 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 2.81 | 16411023 | |
| MESH:D009362 | Neoplasm Metastasis | 4,4'-diaminodiphenylmethane | 5.47 | 3581430 | |
| MESH:D009362 | Neoplasm Metastasis | Tamoxifen | 5.47 | 19393235 | |
| MESH:D009364 | Neoplasm Recurrence, Local | Tamoxifen | 2.46 | 19410462 | |
| MESH:D009369 | Neoplasms | decitabine | 18.72 | 17925555 19116145 19470736 | |
| MESH:D009369 | Neoplasms | Fenretinide | 18.72 | 15958647 17353921 | |
| MESH:D009369 | Neoplasms | Fluorouracil | 18.72 | 18239605 16928823 18600527 | |
| MESH:D009369 | Neoplasms | Lindane | 18.72 | 16818664 12807735 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 18.72 | 17405874 | |
| MESH:D009369 | Neoplasms | sodium arsenite | 18.72 | 11559025 | |
| MESH:D009374 | Neoplasms, Experimental | sodium arsenite | 3.50 | 20056578 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | Tamoxifen | 3.83 | 19196722 19189210 19200415 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 4.27 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.14 | 19348381 18481113 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 3.05 | 14600291 | |
| MESH:D009436 | Neural Tube Defects | 4,4'-diaminodiphenylmethane | 6.89 | 6679447 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenite | 6.89 | 12854658 | |
| MESH:D009472 | Neuronal Ceroid-Lipofuscinoses | Fenretinide | 5.51 | 16303764 | |
| MESH:D020258 | Neurotoxicity Syndromes | Fluorouracil | 3.32 | 16436463 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.77 | 20558911 | |
| MESH:D009784 | Occupational Diseases | 4,4'-diaminodiphenylmethane | 3.27 | 4026338 6482804 | |
| MESH:D009902 | Optic Neuritis | 4,4'-diaminodiphenylmethane | 4.85 | 3988306 | |
| MESH:D010051 | Ovarian Neoplasms | decitabine | 14.45 | 19259094 19331143 | |
| MESH:D010051 | Ovarian Neoplasms | Fenretinide | 14.45 | 16133793 | |
| MESH:D010051 | Ovarian Neoplasms | sodium arsenite | 14.45 | 15276417 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | trichostatin A | 14.45 | 19331143 | |
| MESH:D010051 | Ovarian Neoplasms | U 0126 | 14.45 | 16211241 | |
| MESH:D010190 | Pancreatic Neoplasms | decitabine | 15.71 | 19294695 | |
| MESH:D010190 | Pancreatic Neoplasms | Fenretinide | 15.71 | 15580305 | |
| MESH:D010190 | Pancreatic Neoplasms | Fluorouracil | 15.71 | 19003803 16929163 16500647 15113037 | |
| MESH:D010190 | Pancreatic Neoplasms | Tetradecanoylphorbol Acetate | 15.71 | 15976015 | |
| MESH:D010190 | Pancreatic Neoplasms | trichostatin A | 15.71 | 19294695 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 3.53 | 11578682 | |
| MESH:D010212 | Papilloma | 4,4'-diaminodiphenylmethane | 8.83 | 7296757 | |
| MESH:D010212 | Papilloma | Tetradecanoylphorbol Acetate | 8.83 | 18922899 12065085 18404319 8330346 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 4.08 | 12520081 | |
| MESH:D010787 | Photosensitivity Disorders | 4,4'-diaminodiphenylmethane | 4.30 | 6228378 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 3.39 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 3.08 | 12371664 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 3.02 | 11896295 11399792 11118676 11222880 | |
| MESH:D055728 | Primary Myelofibrosis | decitabine | 11.86 | 17616702 | |
| MESH:D055728 | Primary Myelofibrosis | trichostatin A | 11.86 | 17616702 | |
| MESH:D011471 | Prostatic Neoplasms | Fenretinide | 1.90 | 17024972 | |
| MESH:D011471 | Prostatic Neoplasms | Fluorouracil | 1.90 | 18626508 19082440 | |
| MESH:D011471 | Prostatic Neoplasms | Lindane | 1.90 | 14688026 12661182 | |
| MESH:D011471 | Prostatic Neoplasms | sodium arsenite | 1.90 | 16039940 | |
| MESH:D011471 | Prostatic Neoplasms | Tamoxifen | 1.90 | 15067354 | |
| MESH:D011471 | Prostatic Neoplasms | trichostatin A | 1.90 | 19789329 18798265 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 3.14 | 15861022 16919318 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.17 | 16882103 | |
| MESH:D012004 | Rectal Neoplasms | Fluorouracil | 3.86 | 15538739 16160472 18722050 18286688 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.30 | 19058328 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 3.67 | 18990726 | |
| MESH:D012162 | Retinal Degeneration | 4,4'-diaminodiphenylmethane | 8.69 | 3692021 | |
| MESH:D012162 | Retinal Degeneration | Fenretinide | 8.69 | 16303925 | |
| MESH:D012208 | Rhabdomyosarcoma | decitabine | 4.24 | 19155313 | |
| MESH:D012640 | Seizures | Lindane | 3.51 | 12842176 7539098 15475178 | |
| MESH:D012878 | Skin Neoplasms | Fenretinide | 17.10 | 16467112 | |
| MESH:D012878 | Skin Neoplasms | sodium arsenite | 17.10 | 19524636 18572023 | |
| MESH:D012878 | Skin Neoplasms | tert-Butylhydroperoxide | 17.10 | 8532709 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 17.10 | 16192470 | |
| MESH:D012878 | Skin Neoplasms | Tetradecanoylphorbol Acetate | 17.10 | 8985016 8330346 12065085 18404319 11807781 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 10.98 | 16709447 | |
| MESH:D013088 | Spermatocele | Tamoxifen | 10.98 | 16709447 | |
| MESH:D013119 | Spinal Cord Injuries | Tamoxifen | 3.87 | 19457130 | |
| MESH:D016135 | Spinal Dysraphism | sodium arsenite | 3.66 | 12854658 | |
| MESH:D013274 | Stomach Neoplasms | decitabine | 3.41 | 19037991 | |
| MESH:D013274 | Stomach Neoplasms | Fluorouracil | 3.41 | 18396642 19084572 16951190 17522103 16424979 15786421 17172411 18567086 17498489 19015929 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 3.41 | 17575124 12958204 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 3.46 | 11994571 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 3.01 | 15669648 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 3.73 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | 4,4'-diaminodiphenylmethane | 6.81 | 3712494 6582329 7505956 1399818 6587162 | |
| MESH:D013964 | Thyroid Neoplasms | decitabine | 6.81 | 17967635 | |
| MESH:D014062 | Tongue Neoplasms | Fluorouracil | 3.84 | 16280240 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 4,4'-diaminodiphenylmethane | 15.11 | 8074119 | |
| MESH:D001749 | Urinary Bladder Neoplasms | decitabine | 15.11 | 19087683 17616700 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Fenretinide | 15.11 | 16720286 | |
| MESH:D001749 | Urinary Bladder Neoplasms | sodium arsenite | 15.11 | 16712894 11723127 16452187 17306315 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Tamoxifen | 15.11 | 8653321 17572228 16712894 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fenretinide | 15.11 | 16154183 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fluorouracil | 15.11 | 16803524 | |
| MESH:D002583 | Uterine Cervical Neoplasms | sodium arsenite | 15.11 | 11813266 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 3.13 | 14692618 | |
| MESH:D014604 | Uveal Neoplasms | decitabine | 4.74 | 17785578 | |
| MESH:D014605 | Uveitis | Cyclosporine | 3.81 | 1336536 | |
| MESH:D014652 | Vascular Diseases | sodium arsenite | 4.25 | 17056641 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 4.42 | 12125929 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 3.38 | 14671159 15869587 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 4.08 | 15886252 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 4.27 | 17120751 |
| No data |