AutismKB 2.0

Annotation Detail for AKAP1


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Basic Information Top
Gene Symbol:AKAP1 ( AKAP,AKAP121,AKAP149,AKAP84,D-AKAP1,MGC1807,PRKA1,SAKAP84 )
Gene Full Name: A kinase (PRKA) anchor protein 1
Band: 17q22
Quick LinksEntrez ID:8165; OMIM: 602449; Uniprot ID:AKAP1_HUMAN; ENSEMBL ID: ENSG00000121057; HGNC ID: 367
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AKAP1 mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AKAP1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AKAP1 mRNAdecreases expression 20018196
D002118 Calcium Calcium affects the expression of AKAP1 mRNAaffects expression 15913539
D016572 Cyclosporine Cyclosporine results in decreased expression of AKAP1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of AKAP1 mRNAincreases expression 18042831
D004958 Estradiol Estradiol affects the expression of AKAP1 mRNAaffects expression 14699072
D005419 Flavonoids Flavonoids results in increased expression of AKAP1 mRNAincreases expression 18035473
D005978 Glutathione Glutathione deficiency results in increased expression of AKAP1 mRNAincreases expression 15345336
C041786 palm oil palm oil results in increased expression of AKAP1 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of AKAP1 mRNAincreases expression 18301758
D020849 Raloxifene Raloxifene affects the expression of AKAP1 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of AKAP1 mRNAincreases expression 19933214
D014501 Uranium Uranium affects the expression of AKAP1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of AKAP1 mRNAaffects expression 15672453
C025643 vinclozolin vinclozolin results in decreased expression of AKAP1 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Estradiol 2.0911473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000419 Albuminuria Raloxifene 4.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001008 Anxiety Disorders vinclozolin 3.6219015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001321 Autistic Disorder Glutathione 3.0116917939 19267885 19056591 18929414
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001943 Breast Neoplasms Dietary Fats 2.3220435547
MESH:D001943 Breast Neoplasms Estradiol 2.3217289903 17261762 18497071 19861407 14630087 16675129 17018787 12948864
MESH:D001943 Breast Neoplasms Raloxifene 2.3217049068 16912660 15572757 15758505 17893378 16837676 15775269 17595753 17952589 17242785 17261762 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 2.3216202921 19288272 11161223 19221464 18351453 19487384 19289846 19189212 19103187 17893378 20135344 17049068 19142967 19084267 18855134 17261762 20005174 19011961 18984771 20390343 18629630 15565566 19115204 19189210 19155303 18815881 18425577 20544844 16873071 15668708 19059307 17242785 20859285 16273361 19410462 21138602 18821012 18997820 21152245 17440819 20065188 19200415 19066611 19244106 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 2.9716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9716924424
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3717015178
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4315775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.0518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis Cyclosporine 7.7019486331
MESH:D002779 Cholestasis pirinixic acid 7.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 15340226 12621046 8697196 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.3214966744
MESH:D003550 Cystic Fibrosis Glutathione 4.4719747007
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004487 Edema pirinixic acid 11.3212083418
MESH:D004487 Edema Raloxifene 11.3215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.1915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.1919031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.3419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3417893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 24.4719224547
MESH:D005234 Fatty Liver Dietary Fats 24.4719551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver pirinixic acid 24.4720131406 19236843
MESH:D005234 Fatty Liver Raloxifene 24.4717473493
MESH:D005234 Fatty Liver Tamoxifen 24.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Cyclosporine 14.6512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.6518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6520067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3016417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.2216221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 16354765 8697196 15340226 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Cyclosporine 8.5410903974
MESH:D006973 Hypertension Raloxifene 8.5417577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.5418850075 18670907
MESH:D007248 Infertility, Male vinclozolin 3.0316467254
MESH:D007249 Inflammation Dietary Fats 11.8720412841
MESH:D007249 Inflammation Flavonoids 11.8717296493
MESH:D007249 Inflammation Tamoxifen 11.8719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.8712878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.2118457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.2116393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.2116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 5.908314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.9015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2712371664
MESH:D007680 Kidney Neoplasms Estradiol 12.2715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 12.2718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.0516316344
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7216417039
MESH:D008064 Lipidoses Tamoxifen 3.1417567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8618296743
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9012878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.2920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.2916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0912151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2419555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9211408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9219196722 16827153 14580682 19196723 11731420
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.4111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D009765 Obesity Dietary Fats 4.4217217161 18674790 20518802 20132043 18457598 21332399 16723640 19632207 11836018
MESH:D009765 Obesity pirinixic acid 4.4220558911
MESH:D010024 Osteoporosis Calcium 7.4817882678
MESH:D010024 Osteoporosis Raloxifene 7.4815775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2117893378 15579764 15758505 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 2.2119401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4611222880 11118676 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.4618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9318220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6016220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6015067354
MESH:D011472 Prostatitis vinclozolin 4.9318629315
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Tamoxifen 4.2916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.2017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.208653321 16712894 17572228
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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