AutismKB 2.0

Annotation Detail for MADCAM1


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Basic Information Top
Gene Symbol:MADCAM1 ( MACAM1 )
Gene Full Name: mucosal vascular addressin cell adhesion molecule 1
Band: 19p13.3
Quick LinksEntrez ID:8174; OMIM: 102670; Uniprot ID:MADCA_HUMAN; ENSEMBL ID: ENSG00000099866; HGNC ID: 6765
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200178Paxillin-independent events mediated by a4b1 and a4b7
No data
Pathway IDPathway Name
500004Integrin cell surface interactions
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MADCAM1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MADCAM1 mRNAaffects expression 16483693
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA]decreases reaction|increases expression 18200517
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of MADCAM1 mRNAincreases expression 15240709
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of MADCAM1 mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1915113128 15688392
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Curcumin 2.6616243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.6616253758 14633655 11306469
MESH:D002277 Carcinoma Curcumin 4.1218593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8418462866
MESH:D002386 Cataract Acetaminophen 8.1810977129
MESH:D002386 Cataract Methylnitrosourea 8.1812484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 4.032727394 7505956
MESH:D003092 Colitis Curcumin 11.6116782535 16804969 18200517
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 11.6118200517 17936198 17991707 16867261 16474422 18023891 16804969 16782535 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5317276891
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7718403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.3318204486
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.662444490 14725611 12392966 19416960 11743745 18071297 14550746 11461765 16177239 11287661 16485898 12153990 16081117 12540782 18713872 10915739 19085960 15968718 10774834 11421492 11739529 14986274 11529661 17522070 12594235 12705907 16393943 19739265 10663392 17906064 16109766 11834606 15619225 16781746 19923254 16227642 19420014 12958197 19164858 17562736 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D005234 Fatty Liver Curcumin 4.0719297423
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.7711555667
MESH:D005355 Fibrosis Curcumin 10.9718705752
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 10.9717994277
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D005910 Glioma Methylnitrosourea 3.679825942
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818829502 18462866
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D007248 Infertility, Male Methylnitrosourea 4.027193160
MESH:D007249 Inflammation Curcumin 3.0516956363 18403477 17151092
MESH:D015212 Inflammatory Bowel Diseases Curcumin 7.0718200517 18596194
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 7.0718200517
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 5.0917994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.5710783313
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4515526292
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2818006644 18705752 17355460
MESH:D008107 Liver Diseases Acetaminophen 4.3419014921 12587719 19784758 11587558 12969438 16610002 19460945 16611625
MESH:D008107 Liver Diseases Curcumin 4.3416956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.9516080182
MESH:D008175 Lung Neoplasms Curcumin 3.0616243823 19359593 18462866
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.0618062963
MESH:D008223 Lymphoma Curcumin 8.8218462866
MESH:D008223 Lymphoma Methylnitrosourea 8.8211418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.1714633661
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.7916827153 11807958 14633655 16619500 17131329 15113128 14999141 10767621 15688392 11751437 12931682 15313902 16051031 17020996 10838139 19196723 16944150
MESH:D008545 Melanoma Curcumin 2.4517885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009369 Neoplasms Methylnitrosourea 3.4515533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.9512696579
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.1412497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D009442 Neurilemmoma Methylnitrosourea 6.0311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Curcumin 2.8119297423
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9019020741 18462866
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Curcumin 6.1217440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 6.1216965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.6017698068
MESH:D011471 Prostatic Neoplasms Curcumin 3.6710851300 11398177 18769126 18156803 18226269 15129424 12497104
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6715682402 12376480
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4318379247 10666014
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.6718155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 6.0311555667
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7018593901 16257854 15930296
MESH:D013276 Stomach Ulcer Curcumin 3.8619188055 16631530
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.7711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.193078959 7505956
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0018593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:13552 Integrin cell surface interactions
KEGG:04672 Intestinal immune network for IgA production
REACT:6900 Signaling in Immune system
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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