AutismKB 2.0

Annotation Detail for ADAMTS12


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Basic Information Top
Gene Symbol:ADAMTS12 ( PRO4389 )
Gene Full Name: ADAM metallopeptidase with thrombospondin type 1 motif, 12
Band: 5p13.3-p13.2
Quick LinksEntrez ID:81792; OMIM: 606184; Uniprot ID:ATS12_HUMAN; ENSEMBL ID: ENSG00000151388; HGNC ID: 14605
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ADAMTS12 mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ADAMTS12 mRNAincreases expression 17484886
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ADAMTS12 mRNAdecreases expression 20713471
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.636695378
MESH:D000236 Adenoma Methylcholanthrene 7.6310545420 6695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6911922910
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2917474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.2917474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.4316011737 15673190 16192424 15700767 16097048 16227642 16050911 15721981 18705752 10355542 16124888 3786805
MESH:D002277 Carcinoma Methylcholanthrene 4.3310545420
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.7916192471
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.136884620 16177239 10092053 15968718 7179309 19085960 2869522 4309450 15027814 9327722 19336974 10915739 16227642 21278145 3786805 17522070 6623471 7120509 3732212 7440962 11566570 15998439
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0916530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.6515959796 17595544 12795759 61145 16045604 19224547 16239168 12631006
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.6810962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 4.1018705752
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1819900420 19110552
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.2716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.7415338365
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0217157831 11408273 17334410 21278145 11903743 16221502 17174718 16239168 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517557913 15959796 17761835 17631135 15123356 12632512 16027843 16192424 12546737 15052691 18376398 18279442 12741479 10355542 15362042 17721639 18251166 16097048 12586293 17900296 12632514 17525996 18429990 18205269 15996030 12667390 15818738 13678700 17714472 16033810 12898905 18418968 18339082 15876570 15730626 12445421 17708605 17976157 15673190 17640975 18412020 17766677 14716496 16011737 14748882 12958196 15338365 18420326 14724832 18395095 14512876 12609069 18472332 18156304 16116963 18187930 18277467 18263696 12649538 14716833 15650968 16015684 18317297 18006644 17922224 18705752 15893842 17565644 17805973 18395914 17698563 16136751 17481882 14620537 17823541 17944888 18472094 18210741 12666154 18481824 12389079 12445418 16638106 15925388 15057751 16248980 15370692 17869086 20821823 15931870 11481614 18054572 18166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1616246199 15830285 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.1416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9619294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 7.0415583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 7.041399818 598648
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7117053015 20869020 18520028 20135361 20464547 20064080 18816296 18569708 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.717750092 16337739 15390079 21163286 9230183 10545420 16271038 17909032 1399818 6695378 11893704 20512841 20970405
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3117053015
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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