AutismKB 2.0

Annotation Detail for VANGL1


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Basic Information Top
Gene Symbol:VANGL1 ( KITENIN,LPP2,MGC5338,STB2,STBM2 )
Gene Full Name: vang-like 1 (van gogh, Drosophila)
Band: 1p13.1
Quick LinksEntrez ID:81839; OMIM: 610132; Uniprot ID:VANG1_HUMAN; ENSEMBL ID: ENSG00000173218; HGNC ID: 15512
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04310Wnt signaling pathway
No data
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Related Diseases/Disorders Top
No data
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Desease Name
Neural tube defects
Caudal regression syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of VANGL1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of VANGL1 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VANGL1 mRNAdecreases expression 19150397
20382639
C029424 hydrazine hydrazine results in increased expression of VANGL1 mRNAincreases expression 15282401
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0315073043 16217749 11135700 14691202 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6712705907 17522070 11743745 10774834 11739529 11834606 18071297 16109766 18713872 16781746 11529661 12594235 17906064 19923254 14550746 2444490 12540782 16485898 12153990 14725611 19739265 11287661 14986274 19164858 10663392 11421492 19416960 15968718 19085960 11461765 12392966 19420014 16177239 12958197 15619225 19370779 10915739 16081117 16393943 17562736 16227642
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7312903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1920471514 16968895 17050201 19850784 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4615622746 17217047 17869043 16330433 12679006 17649720 16966277 9834237 19225113 12712474 16823087 16331271 11468182 19075265 16891316 17107899 16112521 19642359 12018890 11161223 15336539 15213294 15748426 17712046 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 16611625 12587719 19460945 16610002 19014921 11587558 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3815949261 19417148 14977855 11468182 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects marker/mechanism 19319979
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5012452020 19769630 16624393
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2119131511
OMIM:600145 SACRAL DEFECT WITH ANTERIOR MENINGOCELE marker/mechanism
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6011780464 20435036 12973940 12845720
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
KEGG:04310 Wnt signaling pathway
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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