AutismKB 2.0

Annotation Detail for FAHD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FAHD1 ( C16orf36,DKFZp566J2046,MGC74876,YISKL )
Gene Full Name: fumarylacetoacetate hydrolase domain containing 1
Band: 16p13.3
Quick LinksEntrez ID:81889; OMIM: NA; Uniprot ID:FAHD1_HUMAN; ENSEMBL ID: ENSG00000180185; HGNC ID: 14169
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FAHD1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FAHD1 mRNAdecreases expression 19150397
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of FAHD1 mRNAdecreases expression 19638242
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of FAHD1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FAHD1 mRNAdecreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAHD1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FAHD1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of FAHD1 mRNAdecreases expression 18445702
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma Diethylnitrosamine 3.0310737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.7818056438 17620307 17162532 19052882 16434500 19061943
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.7817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.7816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.793084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7920432363 16502159 19383236 18393292 20935162 16328049 16830150 19208518 17162532 17761372 18978308 3084413 19394651 20514400 20101231 19539802 10737359 19052882 16878318 20214788 19418558 16935385 18056438 17055752 17428255 10672840 18971187 18210153 16698587 20727157 18785209 19701751 19519916 16569478 20524982 11831363 20007298 21159647 16807293 16779866 19919837 19171122 20512989 17978847 19107877 19822196 3581430 17173139 16540662 17138121 19335982 16288022 18788625 18506893 18665156 18494052 20084675 18691550 16681979
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7917173139 20007298 1701930 6705139 20935162
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4720889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.4717174075 7505956 2727394 21159647
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0312958197 17562736 16781746 12594235 16177239 10663392 15968718 16485898 14725611 18713872 11421492 11529661 17522070 16393943 10915739 11739529 16081117 12153990 11461765 2444490 19085960 12392966 17906064 11743745 12705907 12540782 19416960 19923254 19739265 14550746 18071297 19370779 11287661 19164858 16109766 19420014 15619225 10774834 11834606 16227642 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0319107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.483922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.9519236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1419772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.2218407596 19638242 20032147 18522880 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 7.2221047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.9212969438 11587558 16611625 19784758 16610002 19014921 12587719 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 6.9217034775
MESH:D008107 Liver Diseases Phenobarbital 6.9219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0718977376 21167192 20101389 19833225 18648771 2422723 20452335 20583210 15175105 19255062 19812893 20492335 18644402 20434301 19254457 19090486 18754104 19256749 19294768 19642983 19426721 19551842 19690152 19427195 12112319 16942905 19638242 21071580 19073162 18978307 12771043 20405173 19499222 19850985 20137499 19996281 21278145 10737359 15885732 20118626 2862719 21047994 20501860 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 8.0719812893 21047994 19482888 8742319 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 8.0715890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.6718093689 18775883 17854601 18079962 19004024 18544905 9362446 19539802 2563599 18164116 3124819 18308698 16842330 19519916 19009564 19126423 17174075 18282651 16267830 21159647 18253720 17942915
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.672563599 1399818 18308698 17172636 6150874
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 21163286 6695378 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.2218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 9.2220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6116965848
MESH:D011230 Precancerous Conditions Diethylnitrosamine 10.192563599
MESH:D011230 Precancerous Conditions Phenobarbital 10.192563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures Phenobarbital 2.9216876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 8.107505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.101399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved