AutismKB 2.0

Annotation Detail for QTRT1


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Basic Information Top
Gene Symbol:QTRT1 ( FP3235,TGT )
Gene Full Name: queuine tRNA-ribosyltransferase 1
Band: 19p13.3
Quick LinksEntrez ID:81890; OMIM: 609615; Uniprot ID:TGT_HUMAN; ENSEMBL ID: ENSG00000213339; HGNC ID: 23797
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of QTRT1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of QTRT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of QTRT1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of QTRT1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of QTRT1 proteindecreases expression 19364129
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of QTRT1 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of QTRT1 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in decreased expression of QTRT1 mRNAdecreases expression 19013527
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of QTRT1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of QTRT1 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite affects the expression of QTRT1 mRNAaffects expression 19590694
D013629 Tamoxifen Tamoxifen results in increased expression of QTRT1 mRNAincreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of QTRT1 mRNAaffects cotreatment|increases expression 17942748
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of QTRT1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of QTRT1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.877525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8714514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3511798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0416712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.7716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.7719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.7712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Tamoxifen 1.9520859285 20065188 17261762 18984771 18815881 19059307 19155303 20005174 19221464 18855134 17893378 16818667 21152245 19066611 20544844 16202921 15565566 19103187 19189212 21138602 19084267 19289846 19189210 19410462 20390343 17242785 20135344 18997820 15668708 18821012 18351453 19142967 18629630 18425577 11161223 19244106 19115204 16273361 19011961 17049068 19288272 19487384 19200415 16873071 17440819
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.003084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.0015073043 14691202 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 9.0017306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.0016924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4018572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.5714694615
MESH:D002386 Cataract Acetaminophen 7.5710977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0420056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.9417110522 11677210 17333356 16919318 15861022 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 7.9419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315668235 8697196 15340226 16354765 12621046
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.4315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.4314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.2718551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.2721346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2719164858 19739265 17562736 11287661 16393943 14986274 12392966 19085960 12594235 11529661 16485898 18071297 15619225 17906064 17522070 18713872 19420014 19416960 10774834 16227642 15968718 11834606 11743745 16781746 11739529 10663392 19923254 14725611 2444490 12153990 19370779 12540782 11421492 16081117 12958197 16109766 12705907 11461765 14550746 10915739 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 12.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1020544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3312903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver arsenic trioxide 19.4615073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4615345470
MESH:D005234 Fatty Liver pirinixic acid 19.4620131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 19.4619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8016452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006333 Heart Failure pirinixic acid 7.1120558911
MESH:D006333 Heart Failure Selenium 7.1117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly pirinixic acid 8.6119772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8217937319
MESH:D007248 Infertility, Male sodium arsenite 6.8212646999 15346721
MESH:D007249 Inflammation Tamoxifen 5.0219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0212200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 10.3315629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 10.3320008137
MESH:D007674 Kidney Diseases Vitamin E 10.3312488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 7.6118625569
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1520471514 16467208 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2611161223 17217047 16891316 16331271 16823087 12679006 16112521 15748426 19035177 15336539 17649720 17712046 19642359 15622746 11468182 17869043 19225113 17107899 15213294 12712474 16966277 16330433 19075265 12018890 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6519784758 16611625 12969438 12587719 19014921 11587558 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 14.5514682389
MESH:D008113 Liver Neoplasms pirinixic acid 14.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 14.5515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 14.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.5516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9720377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases sodium arsenite 7.6219095001
MESH:D008171 Lung Diseases Vitamin E 7.6216863852
MESH:D008175 Lung Neoplasms arsenic trioxide 6.6819825857 11798837
MESH:D008175 Lung Neoplasms sodium arsenite 6.6819931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tamoxifen 6.6818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6811884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.6811062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2115318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2119196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma sodium arsenite 3.3616487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.3612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619417148 19549372 14977855 11468182 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1816882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms pirinixic acid 5.0717405874
MESH:D009369 Neoplasms sodium arsenite 5.0711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319189210 19200415 19196722
MESH:D009410 Nerve Degeneration Rotenone 3.9415790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.5110525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.5112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3916049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.3914694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9819769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9815276417 17306315
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5515580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010300 Parkinson Disease Rotenone 3.0018619942 11535288 18191903 11445065 16140633 19232380 15451049 19114014 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.1515795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0719131511
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0715084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.5818551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.7119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1519014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.1816049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.1811780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.1816712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.1817572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8411813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014652 Vascular Diseases sodium arsenite 4.5417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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