Annotation Detail for MKKS
Basic Information
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| Desease ID | Desease Name |
|---|
| Other genetic disorders |
| H00418 | Bardet-Biedl syndrome |
| Genetic disorders |
| Desease Name |
|---|
| Bardet-Biedl syndrome 6 |
| McKusick-Kaufman syndrome |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in decreased expression of MKKS mRNA | decreases expression | 20406850
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of MKKS mRNA | affects expression | 17562736
|
| D020122 |
tert-Butylhydroperoxide |
tert-Butylhydroperoxide results in decreased expression of MKKS mRNA | decreases expression | 15336504
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.71 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.39 | 18445737 |
| MESH:D020788 |
Bardet-Biedl Syndrome |
marker/mechanism |
|
| |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
2.97 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
2.97 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.81 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.06 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.67 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.05 | 21346803 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.05 | 16393943 12705907 11739529 16109766 19923254 19085960 12540782 16081117 15968718 18071297 19370779 11461765 19164858 16177239 16485898 11287661 18713872 19739265 11529661 19416960 2444490 16227642 10663392 11834606 11743745 12958197 12594235 10915739 19420014 16781746 12392966 12153990 15619225 14725611 17562736 17906064 10774834 14986274 17522070 14550746 11421492 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.96 | 19426721 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.54 | 16983495 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.06 | 16870215 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.42 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.36 | 16705839 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.71 | 19014921 16611625 12969438 16610002 19784758 11587558 19460945 12587719 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.68 | 17185352 16871587 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.28 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.79 | 2876786 2876784 6135515 |
| OMIM:236700 |
MCKUSICK-KAUFMAN SYNDROME |
marker/mechanism |
|
| |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.22 | 19513568 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.60 | 7678174 18551238 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.26 | 18514411 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.88 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.77 | 16870215 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.82 | 18551238 |
| MESH:D012878 |
Skin Neoplasms |
|
tert-Butylhydroperoxide |
2.86 | 8532709 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.42 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
5.06 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.50 | 10982225 |
Related Pathway Information