AutismKB 2.0

Annotation Detail for NCOA3


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Basic Information Top
Gene Symbol:NCOA3 ( ACTR,AIB-1,AIB1,CAGH16,CTG26,KAT13B,MGC141848,RAC3,SRC-3,SRC3,TNRC14,TNRC16,TRAM-1,bHLHe42,pCIP )
Gene Full Name: nuclear receptor coactivator 3
Band: 20q13.12
Quick LinksEntrez ID:8202; OMIM: 601937; Uniprot ID:NCOA3_HUMAN; ENSEMBL ID: ENSG00000124151; HGNC ID: 7670
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
Pathway IDPathway Name
200142Retinoic acid receptors-mediated signaling
200194FOXA1 transcription factor network
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
quantitative calcaneal ultrasound
response to treatment for acute lymphoblastic leukemia
PHARMACOGENOMIC
METABOLIC
bone mass IGF-I levels sex steroid hormones
Desease Name
Response to treatment for acute lymphoblastic leukemia
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C496751 4-(1H-imidazol-1-yl)retinoic acid 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of NCOA3 proteindecreases expression 17145897
C496751 4-(1H-imidazol-1-yl)retinoic acid 4-(1H-imidazol-1-yl)retinoic acid results in decreased expression of NCOA3 proteindecreases expression 17145897
D013196 Dihydrotestosterone NCOA3 protein promotes the reaction [Dihydrotestosterone results in increased expression of AR mRNA]increases expression|increases reaction 16877366
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NCOA3 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NCOA3 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NCOA3 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NCOA3 mRNAdecreases expression 19150397
17944540
C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of NCOA3 protein]decreases reaction|increases degradation 16456540
C006780 bisphenol A bisphenol A results in decreased expression of NCOA3 mRNAdecreases expression 16474171
D016572 Cyclosporine Cyclosporine results in decreased expression of NCOA3 mRNAdecreases expression 20106945
C107676 deguelin deguelin results in decreased expression of NCOA3 mRNAdecreases expression 19365708
C107676 deguelin deguelin results in decreased expression of NCOA3 proteindecreases expression 19365708
D002945 Cisplatin Cisplatin promotes the reaction [NR1I2 protein binds to NCOA3 protein]affects binding|increases reaction 15650019
D002117 Calcitriol Calcitriol promotes the reaction [[VDR protein binds to NCOA3 protein] which binds to CYP24A1 promoter]affects binding|increases reaction 15919092
D002117 Calcitriol Calcitriol affects the localization of NCOA3 proteinaffects localization 15647825
D002117 Calcitriol Calcitriol promotes the reaction [NCOA3 protein binds to CYP24A1 promoter]affects binding|increases reaction 15647825
D002117 Calcitriol Calcitriol promotes the reaction [NCOA3 protein binds to SPP1 promoter]affects binding|increases reaction 15647825
D004958 Estradiol BRCA1 protein affects the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]affects binding|affects reaction|increases reaction 18997820
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to CECR6 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to H19 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to KLRC1 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to NKD1 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to SPATA13 gene]]affects binding|affects reaction|increases reaction 17962382
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]affects binding|increases reaction 18997820
D004958 Estradiol Estradiol promotes the reaction [NCOA3 protein binds to ESR1 promoter]affects binding|increases reaction 19620290
D004958 Estradiol Estradiol promotes the reaction [NCOA3 protein binds to IGF1 promoter]affects binding|increases reaction 17872375
D004958 Estradiol Estradiol promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D004958 Estradiol Estradiol promotes the reaction [NCOA3 protein binds to PTGS2 promoter]affects binding|increases reaction 17872375
D004958 Estradiol Estradiol results in decreased expression of NCOA3 mRNAdecreases expression 16474171
D004958 Estradiol Estradiol results in decreased expression of NCOA3 proteindecreases expression 16739346
D004958 Estradiol Estradiol results in increased expression of NCOA3 mRNAincreases expression 20068009
D019833 Genistein Genistein results in decreased expression of NCOA3 mRNAdecreases expression 16474171
C423914 LG 268 LG 268 promotes the reaction [NCOA3 protein binds to [RXRA protein binds to RXRA protein]]affects binding|increases reaction 15310754
D008043 Linseed Oil Linseed Oil results in decreased expression of NCOA3 proteindecreases expression 21138602
D008628 Mercury Mercury results in increased expression of NCOA3 mRNAincreases expression 16823088
D015741 Metribolone Metribolone inhibits the reaction [NCOA3 protein results in increased activity of AR protein]decreases reaction|increases activity 11981028
D017239 Paclitaxel Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA3 protein]affects binding|increases reaction 15650019
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of NCOA3 mRNAdecreases expression 16474171
D020849 Raloxifene Raloxifene promotes the reaction [NCOA3 protein binds to IGF1 promoter]affects binding|increases reaction 17872375
D020849 Raloxifene Raloxifene promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D020849 Raloxifene Raloxifene promotes the reaction [NCOA3 protein binds to PTGS2 promoter]affects binding|increases reaction 17872375
D012402 Rotenone Rotenone results in increased expression of NCOA3 mRNAincreases expression 19013527
D013629 Tamoxifen BRCA1 protein affects the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]affects binding|affects reaction|increases reaction 18997820
D013629 Tamoxifen NCOA3 results in decreased susceptibility to Tamoxifendecreases response to substance 21059860
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D013629 Tamoxifen Tamoxifen results in increased expression of NCOA3 mRNAincreases expression 20332317
20215421
D013629 Tamoxifen Tamoxifen results in increased expression of NCOA3 proteinincreases expression 20215421
C004648 testosterone enanthate testosterone enanthate results in increased expression of NCOA3 mRNAincreases expression 17440010
D013749 Tetrachlorodibenzodioxin NCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of [AHR protein binds to ARNT protein]]affects binding|increases activity|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin NCOA3 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]increases expression|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [NCOA3 protein binds to CYP1A1 enhancer]affects binding|increases reaction 12024042
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NCOA3 mRNAdecreases expression 20106945
D014212 Tretinoin benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tretinoin results in increased degradation of NCOA3 protein]decreases reaction|increases degradation 16456540
D014212 Tretinoin [RARA protein binds to RXRA protein] promotes the reaction [Tretinoin results in increased degradation of NCOA3 protein]affects binding|increases degradation|increases reaction 16456540
D014212 Tretinoin Tretinoin promotes the reaction [NCOA3 protein binds to HAS2 promoter]affects binding|increases reaction 17307735
D014212 Tretinoin Tretinoin promotes the reaction [NCOA3 protein binds to RARA protein]affects binding|increases reaction 16456540
D014212 Tretinoin [Tretinoin results in increased activity of MAPK14 protein] which results in increased phosphorylation of and results in increased degradation of NCOA3 proteinincreases activity|increases degradation|increases phosphorylation 16456540
D014212 Tretinoin Tretinoin results in increased degradation of NCOA3 proteinincreases degradation 16456540
D014212 Tretinoin Tretinoin results in increased expression of NCOA3 mRNAincreases expression 17218384
D014212 Tretinoin Tretinoin results in increased phosphorylation of NCOA3 proteinincreases phosphorylation 16456540
D014635 Valproic Acid Valproic Acid results in increased expression of NCOA3 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5515322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.558875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.7512690470 15814532 17670903
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7120464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 9.7117638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 9.7111473722
MESH:D000230 Adenocarcinoma Genistein 9.7111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.526695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1516835633
MESH:D000419 Albuminuria Raloxifene 4.3817451421 17308373
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000544 Alzheimer Disease Raloxifene 2.4915800139
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.9416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder Mercury 2.3517497416
MESH:D001321 Autistic Disorder Valproic Acid 2.3516609825 19460635 18177632 17507914 18558336 17157402 20603192 18940202 18316065 17688650 18985861 18396377 18775368 19232924 15238991
MESH:D001327 Autoimmune Diseases Mercury 4.6516634805
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9617594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.2616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.3615867366
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D001930 Brain Injuries Raloxifene 4.2516580743
MESH:D001943 Breast Neoplasms marker/mechanism 20332317
MESH:D001943 Breast Neoplasms 4-(1H-imidazol-1-yl)retinoic acid 12.4017387344 17145897
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 12.4020146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 12.4017123778
MESH:D001943 Breast Neoplasms Calcitriol 12.4011237771
MESH:D001943 Breast Neoplasms Cisplatin 12.4018382427 19526202
MESH:D001943 Breast Neoplasms deguelin 12.4017035597 18593368
MESH:D001943 Breast Neoplasms Estradiol 12.4019861407 12948864 18497071 16675129 17289903 17261762 17018787 14630087
MESH:D001943 Breast Neoplasms Genistein 12.4016873071 16541309 17200150
MESH:D001943 Breast Neoplasms Linseed Oil 12.4021138602
MESH:D001943 Breast Neoplasms Paclitaxel 12.4015136595 11325840 18323546 16115903 16244791 18223236 16273361 18234424
MESH:D001943 Breast Neoplasms Raloxifene 12.4015758505 15572757 16837676 17952589 17595753 15775269 17893378 17261762 16912660 17049068 17242785 17440819
MESH:D001943 Breast Neoplasms Tamoxifen 12.4016273361 19189212 17049068 17261762 19289846 19189210 20065188 18351453 17242785 20135344 16873071 19155303 19487384 19115204 20005174 17893378 17440819 20390343 20859285 19011961 19066611 19221464 19142967 21152245 19059307 15668708 18997820 15565566 16818667 19084267 18855134 18815881 19244106 11161223 18629630 19200415 19410462 20544844 19288272 21138602 19103187 16202921 18821012 18984771 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 12.4020435547
MESH:D001943 Breast Neoplasms Tretinoin 12.4016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 13.5017982673
MESH:D006528 Carcinoma, Hepatocellular deguelin 13.5018575727
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.5016924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.5016313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.501917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9612023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2520419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.2511237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.2517066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.3710334427
MESH:D002318 Cardiovascular Diseases Genistein 6.9816332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9815775269
MESH:D002386 Cataract Tretinoin 2.9617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.2420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.2412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.2418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 2.7519486331
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4516354765 8697196 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 5.459407595
MESH:D003072 Cognition Disorders Raloxifene 4.3915800139
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D003110 Colonic Neoplasms Genistein 2.2517182828
MESH:D015179 Colorectal Neoplasms Cisplatin 3.5615273666
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.5618802399
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.5615531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6110048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6114991402 9224671 8800419 9211117 10589399 16925845 17551590 9142499 9125849 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6117688650 8888407 16575769
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5016140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9717474826
MESH:D017449 Dermatitis, Allergic Contact Mercury 3.5816823706
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1316647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1317107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.9119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.9117308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.9119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.551733752 19641884
MESH:D004362 Drug Toxicity Cisplatin 7.6212649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6211462148
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:D004487 Edema Raloxifene 6.1815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.1718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.1915138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.1915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.1919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Estradiol 16.5718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.5711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.5719155303 20544844 16202921 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 16.5716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.406426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.9316530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.9316481741 15173087 16785472 15464296 17638652
MESH:D004938 Esophageal Neoplasms Paclitaxel 9.9316481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.2816938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 17.1119224547
MESH:D005234 Fatty Liver Raloxifene 17.1117473493
MESH:D005234 Fatty Liver Tamoxifen 17.1114986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 17.1114986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.918888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis Cyclosporine 13.4212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4220067830
MESH:D005355 Fibrosis Tretinoin 13.4217994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Genistein 6.7216598420
MESH:D005909 Glioblastoma Tretinoin 6.7217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.4115102660 15464296
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4116096774
MESH:D034381 Hearing Loss Cisplatin 4.1019898482
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4014991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.3811110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6715340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.5217440010
MESH:D006689 Hodgkin Disease Cisplatin 3.4116200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Tretinoin 3.0416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006973 Hypertension Cyclosporine 8.0710903974
MESH:D006973 Hypertension Raloxifene 8.0717577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0718670907 18850075
MESH:D007249 Inflammation Tamoxifen 4.5019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5012878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 6.9516393666
MESH:D007333 Insulin Resistance Estradiol 6.9516393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9115464296
MESH:D007674 Kidney Diseases Cisplatin 13.4315190930 12649298 19839026 12231392 18289764
MESH:D007674 Kidney Diseases Cyclosporine 13.4318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.4315618244
MESH:D007674 Kidney Diseases Mercury 13.4317934191
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3112371664
MESH:D007680 Kidney Neoplasms Estradiol 11.3115610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3118625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.5611231351
MESH:D007889 Leiomyoma Raloxifene 4.2816973256
MESH:D007938 Leukemia marker/mechanism 19365708
MESH:D007938 Leukemia Genistein 6.0317468513 18980019
MESH:D007938 Leukemia Tretinoin 6.0317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7419850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0112679006 16823087 17217047 17294898 17107899 16788101 19642359 17649720 16935935 19075265 17301526 9834237 16331271 16891316 15748426 17712046 19225113 17361223 17368321 19035177 16766008 16140955 17506722 19029980 17339181
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008064 Lipidoses Tamoxifen 2.9917567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.6117353645
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4117823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.4118397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 6.8520195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 6.8516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8516984957
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 5.661423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0317228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8017365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.3018816296 6695378 18569708 20135361 20464547 20064080 17053015 20869020 18520028
MESH:D008175 Lung Neoplasms Cisplatin 6.3017225452 11798837 6189445
MESH:D008175 Lung Neoplasms deguelin 6.3019336726 16288123
MESH:D008175 Lung Neoplasms Tamoxifen 6.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3011884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9114749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1417203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.1412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.1411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.8719453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.8719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Cisplatin 6.9912883367 17761969 11135225 15577323 12393984 16248763 18332650 16432458 17023156 18505091 12374674 16809738 18176117
MESH:D008545 Melanoma Paclitaxel 6.9912040289 16342250 12025231
MESH:D008545 Melanoma Tamoxifen 6.9912393984 19393235
MESH:D008545 Melanoma Tretinoin 6.9916752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.7415990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.7415990972
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.2016166281 16966607 18303189
MESH:D008654 Mesothelioma Cisplatin 6.2017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0318803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3215863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009101 Multiple Myeloma Paclitaxel 7.0914749477
MESH:D009101 Multiple Myeloma Raloxifene 7.0916497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.9717596541
MESH:D009203 Myocardial Infarction Genistein 2.7717141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9417141266
MESH:D009232 Myxoma Raloxifene 5.3216343187
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.6815867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.6819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.0311141357
MESH:D009369 Neoplasms Cisplatin 11.0316773208
MESH:D009369 Neoplasms deguelin 11.0317764071
MESH:D009369 Neoplasms Tretinoin 11.0316946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2615464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0918481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.7117356569 15790535 18619942
MESH:D009421 Nervous System Malformations bisphenol A 28.4016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 28.4016427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.4016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.4014600291
MESH:D009421 Nervous System Malformations Tretinoin 28.409125849
MESH:D009436 Neural Tube Defects Tretinoin 6.829142499
MESH:D009436 Neural Tube Defects Valproic Acid 6.8216359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.338761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.478761367
MESH:D010014 Osteolysis Paclitaxel 4.7515867366
MESH:D010024 Osteoporosis Genistein 6.8719401787
MESH:D010024 Osteoporosis Raloxifene 6.8717882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.4416169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.4415758505 17823083 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms Cisplatin 14.216897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Estradiol 14.2119401270
MESH:D010051 Ovarian Neoplasms Genistein 14.2119005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 14.2111161223
MESH:D010051 Ovarian Neoplasms Tretinoin 14.2116936753
MESH:D010146 Pain Tretinoin 2.7216870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.1919003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1915976015
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.5116702228
MESH:D010300 Parkinson Disease Rotenone 5.5119114014 15451049 11535288 16412576 18619942 18191903 19232380 16140633 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 3.8815927086 15795934 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.0915464296
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6710923243
MESH:D010997 Pleural Neoplasms Cisplatin 5.1117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0312371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.9110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9111118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.9120603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5515572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 11927493 12237244
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.8816289102 12479363 15754350 18247401 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.8815378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.8817172428 17136230 16729912 16356831
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.8815721890
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8815067354
MESH:D011507 Proteinuria Tretinoin 3.3916636307
MESH:D019310 Pseudolymphoma Valproic Acid 4.3112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9417975199 17365031 17322281 15814490
MESH:D011693 Purpura Raloxifene 5.3215770314
MESH:D051437 Renal Insufficiency Cisplatin 4.1815464296
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.1616116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.1619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2114601052
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Valproic Acid 2.591511512 16876388 14763951 17978042 3137016 11738929 15475178 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.7419755658 10029692
MESH:D012878 Skin Neoplasms deguelin 12.7416041863
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7416192470
MESH:D012878 Skin Neoplasms Tretinoin 12.7416467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1115464296
MESH:D013088 Spermatocele Tamoxifen 4.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5720155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 4.5718396642 15958060 17522103
MESH:D013274 Stomach Neoplasms Paclitaxel 4.5718506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 4.5717261132
MESH:D020521 Stroke Raloxifene 3.6416837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616684133 16045194
MESH:D024801 Tauopathies Paclitaxel 4.5816930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.4215464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 12.9419048282
MESH:D013978 Tibial Fractures Raloxifene 12.9419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.2217053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.2217225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 11.2217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2216712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.9116803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9116129372
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.3915577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9816837676
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D014839 Vomiting Cisplatin 4.4911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3216343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31472
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA446714Neoplasm, Residual
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA452347glucocorticoids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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