AutismKB 2.0

Annotation Detail for NRIP1


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Basic Information Top
Gene Symbol:NRIP1 ( FLJ77253,RIP140 )
Gene Full Name: nuclear receptor interacting protein 1
Band: 21q11.2-q21.1
Quick LinksEntrez ID:8204; OMIM: 602490; Uniprot ID:NRIP1_HUMAN; ENSEMBL ID: ENSG00000180530; HGNC ID: 8001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200142Retinoic acid receptors-mediated signaling
200194FOXA1 transcription factor network
No data
No data
Related Diseases/Disorders Top
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Desease Name
plasma HDL cholesterol (HDL-C) levels
NEUROLOGICAL
METABOLIC
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of NRIP1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of NRIP1 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in increased expression of NRIP1 mRNAincreases expression 16339527
D000450 Aldosterone [Aldosterone binds to NR3C2 protein] which binds to NRIP1 protein alternative formaffects binding 15761029
C068073 Am 580 Am 580 results in increased expression of NRIP1 mRNAincreases expression 16982809
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of NRIP1 mRNAaffects expression 17331233
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NRIP1 mRNAdecreases expression 20018196
17944540
20382639
C006780 bisphenol A bisphenol A results in increased expression of NRIP1 mRNAincreases expression 19371625
D003010 Clorgyline Clorgyline results in increased expression of NRIP1 mRNAincreases expression 19691856
C004742 daidzein daidzein results in increased expression of NRIP1 mRNAincreases expression 15757668
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of NRIP1 mRNAincreases expression 19371625
D002117 Calcitriol Calcitriol results in increased expression of NRIP1 mRNAincreases expression 16002434
D004958 Estradiol Estradiol affects the expression of NRIP1 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in increased expression of NRIP1 mRNAincreases expression 15757668
17555868
16029874
D004958 Estradiol Estradiol affects the expression of NRIP1 mRNAaffects expression 15598610
D004958 Estradiol [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein]affects binding|affects cotreatment|increases reaction 19460436
D005047 Etoposide NRIP1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D015025 Zearalenone Zearalenone results in increased expression of NRIP1 mRNAincreases expression 19371625
D005472 Fluorouracil [Fluorouracil co-treated with irinotecan] results in increased expression of NRIP1 mRNAaffects cotreatment|increases expression 16391804
D005472 Fluorouracil Fluorouracil results in decreased expression of NRIP1 mRNAdecreases expression 16510598
D019833 Genistein Genistein results in increased expression of NRIP1 mRNAincreases expression 15757668
19371625
C086566 glycitein glycitein results in increased expression of NRIP1 mRNAincreases expression 15757668
D017313 Fenretinide Fenretinide results in increased expression of NRIP1 mRNAincreases expression 15958647
C051890 irinotecan [Fluorouracil co-treated with irinotecan] results in increased expression of NRIP1 mRNAaffects cotreatment|increases expression 16391804
D016685 Mitomycin NRIP1 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone NRIP1 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C508548 ormeloxifene [Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein]affects binding|affects cotreatment|increases reaction 19460436
C006253 pirinixic acid pirinixic acid results in increased expression of NRIP1 mRNAincreases expression 18301758
D011732 Pyridoxal Phosphate Pyridoxal Phosphate binds to and results in increased activity of NRIP1 proteinaffects binding|increases activity 17277785
C089730 rosiglitazone rosiglitazone results in increased expression of NRIP1 mRNAincreases expression 16982809
C009277 sodium arsenate sodium arsenate results in decreased expression of NRIP1 mRNAdecreases expression 12727804
C017947 sodium arsenite sodium arsenite results in decreased expression of NRIP1 mRNAdecreases expression 12727804
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NRIP1 mRNAincreases expression 17555868
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of NRIP1 mRNAaffects expression 18691609
D014212 Tretinoin Tretinoin results in increased expression of NRIP1 mRNAincreases expression 16249480
D014212 Tretinoin Tretinoin affects the reaction [NRIP1 protein binds to NR2C1 promoter]affects binding|affects reaction 17389641
D014212 Tretinoin Tretinoin results in increased expression of NRIP1 mRNAincreases expression 16604517
D014415 Tunicamycin Tunicamycin results in increased expression of NRIP1 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5614514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma daidzein 12.7311473722
MESH:D000230 Adenocarcinoma Estradiol 12.7311473722
MESH:D000230 Adenocarcinoma Fenretinide 12.7310697514
MESH:D000230 Adenocarcinoma Fluorouracil 12.7317638652
MESH:D000230 Adenocarcinoma Genistein 12.7311473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.583712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6017306315 16712894
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease rosiglitazone 2.7919621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2015469931
MESH:D000740 Anemia Fluorouracil 7.8316511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8311748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D001169 Arthritis, Experimental Tretinoin 2.9016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 2.2516456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.721440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.7419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.7412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.7416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.8614601052
MESH:D001862 Bone Resorption bisphenol A 3.6011985600
MESH:D001932 Brain Neoplasms Fenretinide 4.1016187019
MESH:D001943 Breast Neoplasms bisphenol A 6.6717123778
MESH:D001943 Breast Neoplasms Calcitriol 6.6711237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.6717129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 6.6717289903 17018787 16675129 14630087 12948864 18497071 17261762 19861407
MESH:D001943 Breast Neoplasms Etoposide 6.6716322251
MESH:D001943 Breast Neoplasms Fenretinide 6.6716601279
MESH:D001943 Breast Neoplasms Fluorouracil 6.6718608205 18357371 15136595 16595493 16557594 16110121 19217205
MESH:D001943 Breast Neoplasms Genistein 6.6716541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 6.6716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3716051944
MESH:D002277 Carcinoma Fluorouracil 7.4217121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4216835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 18.883581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.883084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 18.8815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 18.8816924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 18.8817159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 18.8816332177 17088986 17045692 17971768 16799960 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 18.8816924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.8815276417 16507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 18.881917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6917123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.037296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.0318695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.3811237771
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.3816274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.3816757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.3818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.3816096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Aldosterone 11.3611230374
MESH:D002318 Cardiovascular Diseases daidzein 11.3616332659
MESH:D002318 Cardiovascular Diseases Genistein 11.3616332659
MESH:D002386 Cataract Acetaminophen 11.4710977129
MESH:D002386 Cataract Am 580 11.4717460283
MESH:D002386 Cataract Tretinoin 11.4717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.377505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.3720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3718566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.3719524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 11.9916154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 11.9916129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.139022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.1319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3515668235 16354765 15340226 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.359407595
MESH:D003092 Colitis Am 580 8.9717035595
MESH:D003092 Colitis Tretinoin 8.9717035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5615001691 17169374 17725105 16510598 16340194 17287894 18772588 17016597 17018589 17172411
MESH:D003110 Colonic Neoplasms Genistein 5.5617182828
MESH:D003110 Colonic Neoplasms irinotecan 5.5617725105 17287894
MESH:D015179 Colorectal Neoplasms Fenretinide 3.4617273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4618509181 17016601 16282729 17594712 18802399 14970324 18288408 18448328 16331619 16391804 16524972 15289873 17094418 17401013 18949393 17255274 20501625 17695437 15148649 18383874 16303861 17454858
MESH:D015179 Colorectal Neoplasms irinotecan 3.4616391804 17454858 17159606 18259882 18509181 16303861 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.6810525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6810048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.689125849 10589399 9224671 17551590 14991402 16925845 9211117 9142499 9664655 8800419
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2812952375 16002989
MESH:D007644 Darier Disease Fluorouracil 4.5016733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.538156756 14531868 18759878 11906362 12868966 8970840 11298694 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.223621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0517446233
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 9.6816647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.6816647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.6812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.2218289764 9022650 8291058 6679447 18648102 16192314 18692083 1440618 11289319 6482804 9328219 7440962 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.2219420014 11287661 14550746 19739265 11421492 19416960 12153990 11743745 19164858 16177239 2444490 14986274 17522070 18713872 12540782 12958197 12392966 11739529 16393943 14725611 11529661 17906064 19370779 11834606 15619225 16227642 19923254 16109766 12594235 16781746 10774834 16081117 16485898 12705907 17562736 18071297 10663392 15968718 10915739 19085960 11461765
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.2218186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004487 Edema pirinixic acid 9.9612083418
MESH:D004487 Edema rosiglitazone 9.9612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9415322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.6615138306
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.9116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.9116402032
MESH:D016889 Endometrial Neoplasms daidzein 21.3311473722
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 21.3316804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 21.3319148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 21.3311473722
MESH:D016889 Endometrial Neoplasms Tretinoin 21.3316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.779294722 10568697
MESH:D007172 Erectile Dysfunction daidzein 4.7314972507
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.763581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7620426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7616481741 15173087 17638652 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1116938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 7.0919236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 7.0919196556
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.4816002989 16611131 16513791 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.726705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6620067830
MESH:D005355 Fibrosis Tretinoin 7.6617994277
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.8316452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.8316452187
MESH:D005909 Glioblastoma Fenretinide 10.9016187019
MESH:D005909 Glioblastoma Genistein 10.9016598420
MESH:D005909 Glioblastoma Tretinoin 10.9017312396
MESH:D005910 Glioma Fluorouracil 2.7516145905
MESH:D018149 Glucose Intolerance sodium arsenate 4.8119446573
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.767505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1418337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.0214991402 9664655
MESH:D006331 Heart Diseases Mitoxantrone 3.9516019553
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.236705139
MESH:D006529 Hepatomegaly pirinixic acid 7.3016221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006561 Herpes Simplex Etoposide 4.2710809021
MESH:D006689 Hodgkin Disease Etoposide 6.8416135485 18180244 17606976 16200630 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 6.8412676792
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 11.7616870215
MESH:D006930 Hyperalgesia rosiglitazone 11.7612083418
MESH:D006930 Hyperalgesia Tretinoin 11.7616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.8715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.8712960047 14722030
MESH:D006973 Hypertension daidzein 5.1417169123
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.2916002989
MESH:D007246 Infertility Diethylstilbestrol 4.0715036965
MESH:D007248 Infertility, Male sodium arsenite 2.8015346721 12646999
MESH:D007249 Inflammation rosiglitazone 4.6612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 16.1016393666
MESH:D007333 Insulin Resistance Estradiol 16.1016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.1016306350
MESH:D007333 Insulin Resistance rosiglitazone 16.1016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.729022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0517551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 9.0512587719 15629191
MESH:D007674 Kidney Diseases Estradiol 9.0515618244
MESH:D007674 Kidney Diseases sodium arsenite 9.0520008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 15.846582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 15.8416762066 14681315 15003126
MESH:D007680 Kidney Neoplasms Estradiol 15.8415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 15.8416985049
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7717184923
MESH:D007938 Leukemia Genistein 5.9217468513 18980019
MESH:D007938 Leukemia Tretinoin 5.9217143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6618172266
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0319850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9616935935 17368321 19642359 15748426 17294898 17339181 19035177 17506722 19225113 16331271 17301526 17217047 9834237 16766008 16823087 17107899 19029980 17712046 16891316 12679006 17361223 16140955 16788101 19075265 17649720
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7416707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.2117823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.2115474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 8.2115980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.2118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.5616610002 11587558 19460945 16611625 12969438 12587719 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9816871587 17185352
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.4815890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 16.4815113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Mitomycin 16.4815113037
MESH:D008113 Liver Neoplasms pirinixic acid 16.4820007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 16.4815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.4816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 5.126587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1212151625
MESH:D008171 Lung Diseases sodium arsenite 2.9819095001
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7417365036
MESH:D008175 Lung Neoplasms Fluorouracil 3.2215246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.2219931552 17077188 15276417 16712894 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2211884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5015086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8515166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.2215700306
MESH:D008223 Lymphoma Etoposide 7.2212854902 12556972
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2216002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.8016891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 12.8010697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.8014578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 12.8016827153
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Fenretinide 4.8916270382
MESH:D008545 Melanoma sodium arsenite 4.8919082730 16487513
MESH:D008545 Melanoma Tretinoin 4.8916752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0716966607 16166281 18303189
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1417261469
MESH:D009062 Mouth Neoplasms Fenretinide 8.2016274795
MESH:D009062 Mouth Neoplasms Fluorouracil 8.2018986760 16757204
MESH:D052016 Mucositis irinotecan 4.7117159606
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5918186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9117596541
MESH:D009203 Myocardial Infarction Genistein 5.2617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.523581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.5218259882
MESH:D009369 Neoplasms Diethylstilbestrol 21.7815313581
MESH:D009369 Neoplasms Fenretinide 21.7815958647 17353921
MESH:D009369 Neoplasms Fluorouracil 21.7816928823 18600527 18239605
MESH:D009369 Neoplasms Mitoxantrone 21.7816640825
MESH:D009369 Neoplasms pirinixic acid 21.7817405874
MESH:D009369 Neoplasms sodium arsenite 21.7811559025
MESH:D009369 Neoplasms Tretinoin 21.7816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009421 Nervous System Malformations bisphenol A 34.6116427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 34.6111399458
MESH:D009421 Nervous System Malformations Estradiol 34.6111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 34.6116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 34.6114600291
MESH:D009421 Nervous System Malformations Tretinoin 34.619125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 15.796679447
MESH:D009436 Neural Tube Defects sodium arsenate 15.7910525206 11749123 19446573 18186108
MESH:D009436 Neural Tube Defects sodium arsenite 15.7912854658
MESH:D009436 Neural Tube Defects Tretinoin 15.799142499
MESH:D009447 Neuroblastoma irinotecan 3.338761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6318514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.438761367
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3816303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2416436463
MESH:D009765 Obesity pirinixic acid 1.7420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.176482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.723988306
MESH:D010024 Osteoporosis Genistein 7.4519401787
MESH:D010024 Osteoporosis ormeloxifene 7.4515261309
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8116169203
MESH:D010049 Ovarian Diseases bisphenol A 4.6911985600
MESH:D010051 Ovarian Neoplasms Estradiol 13.9519401270
MESH:D010051 Ovarian Neoplasms Fenretinide 13.9516133793
MESH:D010051 Ovarian Neoplasms Genistein 13.9519005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.9515276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 13.9516936753
MESH:D010146 Pain Acetaminophen 5.8116870215
MESH:D010146 Pain Tretinoin 5.8116870215
MESH:D010190 Pancreatic Neoplasms Etoposide 15.1919003803
MESH:D010190 Pancreatic Neoplasms Fenretinide 15.1915580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.1916500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 15.1915113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.1915976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.207296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.176228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8714722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3815687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6010923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 14.5710548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.5717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.5711222880 11399792 11896295 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.4815572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6720887781
MESH:D011471 Prostatic Neoplasms AGN 194204 4.0916000583
MESH:D011471 Prostatic Neoplasms bisphenol A 4.0916740699
MESH:D011471 Prostatic Neoplasms Calcitriol 4.0918247401 16289102 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Clorgyline 4.0919691856
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.0917136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 4.0916740699
MESH:D011471 Prostatic Neoplasms Etoposide 4.0917172428
MESH:D011471 Prostatic Neoplasms Fenretinide 4.0917024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.0918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 4.0916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 4.0916039940
MESH:D011507 Proteinuria Tretinoin 3.3316636307
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4910548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9217322281 17365031 17975199 15814490
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7618722050 18286688 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.393692021
MESH:D012162 Retinal Degeneration Fenretinide 8.3916303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316116481 16283617
MESH:D012512 Sarcoma, Ewing's Etoposide 4.4214601052
MESH:D012878 Skin Neoplasms Fenretinide 12.4416467112
MESH:D012878 Skin Neoplasms sodium arsenite 12.4419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.4416192470
MESH:D012878 Skin Neoplasms Tretinoin 12.4416467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.4116709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3017522103 19015929 17498489 18567086 17172411 19084572 16424979 16951190 18396642 15786421
MESH:D013274 Stomach Neoplasms irinotecan 3.3015723263
MESH:D013274 Stomach Neoplasms Tretinoin 3.3017261132
MESH:D019966 Substance-Related Disorders bisphenol A 3.6916045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.401399818 6582329 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 6.4017045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 8.9816280240
MESH:D014062 Tongue Neoplasms Tretinoin 8.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.018074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.0116712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 11.0116720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.0117306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 26.9316175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 26.9316154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 26.9316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 26.9311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 26.9316129372
MESH:D014591 Uterine Diseases bisphenol A 12.8114652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.8114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7915809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB06884 - 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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