AutismKB 2.0

Annotation Detail for C21orf33


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Basic Information Top
Gene Symbol:C21orf33 ( ES1,GT335,HES1,KNPH,KNPI )
Gene Full Name: chromosome 21 open reading frame 33
Band: 21q22.3
Quick LinksEntrez ID:8209; OMIM: 601659; Uniprot ID:ES1_HUMAN; ENSEMBL ID: ENSG00000160221; HGNC ID: 1273
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001241 Aspirin Aspirin results in increased expression of C21ORF33 mRNAincreases expression 11906190
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of C21ORF33 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of C21ORF33 mRNAdecreases expression 20106945
C106014 gedunin gedunin results in decreased expression of C21ORF33 mRNAdecreases expression 17010675
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of C21ORF33 mRNAaffects cotreatment|increases expression 17183730
C008493 methylselenic acid methylselenic acid results in decreased expression of C21ORF33 mRNAdecreases expression 18548127
D013467 Sulindac Sulindac results in decreased expression of C21ORF33 mRNAdecreases expression 11906190
C050414 tripterine tripterine results in decreased expression of C21ORF33 mRNAdecreases expression 17010675
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of C21ORF33 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E Vitamin E results in increased expression of C21ORF33 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.7614745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D058186 Acute Kidney Injury Sulindac 4.487897758
MESH:D000230 Adenocarcinoma Sulindac 3.1511910360
MESH:D000236 Adenoma Sulindac 3.8710223192
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.7616460482 11535846 17611924 11874996 12394442 19003578 15623613
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8420485159 12372130
MESH:D001321 Autistic Disorder Valproic Acid 1.9918775368 17507914 18177632 20603192 18316065 19232924 16609825 18558336 17688650 18396377 17157402 18985861 15238991 18940202 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001913 Bowen's Disease Sulindac 5.6211207687
MESH:D001932 Brain Neoplasms Aspirin 4.5815481559
MESH:D001943 Breast Neoplasms Aspirin 2.8515161893
MESH:D001943 Breast Neoplasms Sulindac 2.8516642371
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003110 Colonic Neoplasms Aspirin 4.4512411196
MESH:D003110 Colonic Neoplasms Sulindac 4.4512458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.1617047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1611197048 10666051 18059344 11076880
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7617688650 8888407 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7619769572
MESH:D003930 Diabetic Retinopathy Sulindac 5.3817621415 12861449
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.211733752 19641884
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Aspirin 4.0617259670
MESH:D004715 Endometriosis Sulindac 4.6315652904
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms Sulindac 3.1712235107
MESH:D005234 Fatty Liver Cyclosporine 8.3319224547
MESH:D005234 Fatty Liver Valproic Acid 8.3314986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.338888407 18558336
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.7114745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.3719069698
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2111910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D005909 Glioblastoma Aspirin 4.0612870263
MESH:D006261 Headache Aspirin 5.2215240983
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D012001 Hyperacusis Aspirin 6.0315240983
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007249 Inflammation Sulindac 3.383291741
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007414 Intestinal Neoplasms Sulindac 4.8012584176 12663524 10213222 12628509 10223192 12351151
MESH:D007417 Intestinal Polyps Sulindac 5.1712394442 11245490
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.338314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3212468960
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Sulindac 3.0616867024 14986274
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms Sulindac 2.8815713900 19359593
MESH:D008175 Lung Neoplasms Vitamin E 2.8811062179
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D008881 Migraine Disorders Aspirin 8.2715240983
MESH:D008881 Migraine Disorders Valproic Acid 8.2718765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2417596541
MESH:D009203 Myocardial Infarction Aspirin 3.6112692751
MESH:D009325 Nausea Aspirin 5.4815240983
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009436 Neural Tube Defects Valproic Acid 3.2316359493 8888407
MESH:D019636 Neurodegenerative Diseases Sulindac 4.4116850258 17266991
MESH:D010003 Osteoarthritis Aspirin 4.157009135
MESH:D010146 Pain Aspirin 7.936363464 6995502
MESH:D010146 Pain Sulindac 7.933291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4011504793 16820089
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.7811156591
MESH:D020795 Photophobia Aspirin 6.0315240983
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.4916205645
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4915084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012220 Rhinitis Aspirin 4.5312372130
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.851511512 11738929 14763951 16876388 11044598 17978042 3137016 15475178
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4812269725
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.768532709
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D020521 Stroke Aspirin 9.3816403987
MESH:D020521 Stroke Vitamin E 9.3816517955
MESH:D013927 Thrombosis Aspirin 4.6717672075
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Aspirin 4.6210982225 20485159
MESH:D014594 Uterine Neoplasms Sulindac 4.8018645019
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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