AutismKB 2.0

Annotation Detail for CANX


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Basic Information Top
Gene Symbol:CANX ( CNX,FLJ26570,IP90,P90 )
Gene Full Name: calnexin
Band: 5q35.3
Quick LinksEntrez ID:821; OMIM: 114217; Uniprot ID:CALX_HUMAN; ENSEMBL ID: ENSG00000127022; HGNC ID: 1473
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
hsa04145Phagosome
hsa04612Antigen processing and presentation
Pathway IDPathway Name
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500697Assembly of Viral Components at the Budding Site
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
Desease Name
nephrogenic diabetes insipidus
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CANX mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CANX mRNAincreases expression 16788091
D024502 alpha-Tocopherol alpha-Tocopherol affects the localization of CANX proteinaffects localization 16908007
D024502 alpha-Tocopherol alpha-Tocopherol results in increased expression of CANX mRNAincreases expression 16908007
D024502 alpha-Tocopherol alpha-Tocopherol results in increased expression of CANX proteinincreases expression 16908007
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CANX mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of CANX proteindecreases expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of CANX mRNAincreases expression 20458559
C095105 bexarotene bexarotene results in increased expression of CANX mRNAincreases expression 16648578
C110904 capecitabine CANX results in decreased susceptibility to [Fluorouracil co-treated with capecitabine]affects cotreatment|decreases response to substance 18678097
D002509 Cephaloridine Cephaloridine results in increased expression of CANX mRNAincreases expression 18172885
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of CANX mRNAdecreases expression 11906922
D016572 Cyclosporine Cyclosporine results in increased expression of CANX mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of CANX mRNAincreases expression 18172885
D016190 Carboplatin Carboplatin results in decreased expression of CANX mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of CANX mRNAdecreases expression 18246545
D004642 Emodin Emodin results in decreased expression of CANX mRNAdecreases expression 16045814
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in increased expression of CANX proteinincreases expression 16908007
D005472 Fluorouracil CANX results in decreased susceptibility to [Fluorouracil co-treated with capecitabine]affects cotreatment|decreases response to substance 18678097
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of CANX mRNA]affects reaction|decreases expression 15016801
D005839 Gentamicins Gentamicins results in increased expression of CANX mRNAincreases expression 18172885
D017313 Fenretinide Fenretinide results in increased expression of CANX proteinincreases expression 17353921
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNAaffects cotreatment|increases expression 17183730
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to CANX protein]affects binding|increases reaction 17220478
D009532 Nickel MT1 affects the reaction [Nickel affects the expression of CANX mRNA]affects expression|affects reaction 16166738
D009532 Nickel MT2 affects the reaction [Nickel affects the expression of CANX mRNA]affects expression|affects reaction 16166738
C029938 nickel sulfate nickel sulfate results in decreased expression of CANX mRNAdecreases expression 16780908
D019284 Thapsigargin Thapsigargin results in increased expression of CANX proteinincreases expression 17353921
D014501 Uranium Uranium affects the expression of CANX mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of CANX mRNAaffects expression 15672453
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of CANX mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of CANX mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.288875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7419490988
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D058186 Acute Kidney Injury Cisplatin 8.5115814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Gentamicins 8.5111274264
MESH:D055371 Acute Lung Injury Nickel 9.0316166738
MESH:D055371 Acute Lung Injury nickel sulfate 9.0311954676 12718980 19131640 16100012
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8211798837 19825857
MESH:D000230 Adenocarcinoma Cisplatin 9.8211798837 17638652
MESH:D000230 Adenocarcinoma Fenretinide 9.8210697514
MESH:D000230 Adenocarcinoma Fluorouracil 9.8217638652
MESH:D000550 Amblyopia Valproic Acid 5.0217688650
MESH:D000740 Anemia Fluorouracil 3.5315504547 17963324 16511603
MESH:D001008 Anxiety Disorders Valproic Acid 8.3117497229
MESH:D001008 Anxiety Disorders vinclozolin 8.3119015723
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.3915014928
MESH:D001321 Autistic Disorder Valproic Acid 2.0217688650 19460635 16609825 18940202 18177632 20603192 18316065 19232924 17157402 18396377 18775368 18558336 17507914 15238991 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 2.9720046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.4816206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.278888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D001932 Brain Neoplasms Fenretinide 4.1716187019
MESH:D001943 Breast Neoplasms bexarotene 3.6516344269 16818667
MESH:D001943 Breast Neoplasms capecitabine 3.6518473752 12972520
MESH:D001943 Breast Neoplasms Cisplatin 3.6519526202 18382427
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.6515136595 17388661 16978400 18323546 15093573 18234424 11325840 12006526 17020986
MESH:D001943 Breast Neoplasms Fenretinide 3.6516601279
MESH:D001943 Breast Neoplasms Fluorouracil 3.6516557594 16110121 18608205 16595493 19217205 18357371 15136595
MESH:D001943 Breast Neoplasms Nickel 3.6515986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1311589617
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4616051944
MESH:D002277 Carcinoma Fluorouracil 3.4017121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.9516705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 10.9516217749 14691202 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 10.9517982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 10.9519701751
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 10.9517159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 10.9516332177 17088986 16799960 17971768 18930000 17045692
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.6816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 8.8116247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 8.8116685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 8.8112023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6619014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 10.5016201981
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 10.508340253
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.5018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9312490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.3818337622 17066447 6189445
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 7.3816274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.3816757204 18986760 16280240 17066447
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.3912371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2616154183
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D002779 Cholestasis Cyclosporine 2.7619486331
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2016510598 17287894 17725105 17018589 15001691 17016597 17169374 18772588 16340194 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.2920501625
MESH:D015179 Colorectal Neoplasms capecitabine 6.2918473752 18448328
MESH:D015179 Colorectal Neoplasms Cisplatin 6.2915273666
MESH:D015179 Colorectal Neoplasms Fenretinide 6.2917273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 6.2916524972 18802399 18509181 16282729 20501625 17594712 17695437 18288408 14970324 18949393 15148649 16391804 16303861 18448328 17454858 15289873 16331619 17016601 17094418 17255274 17401013 18383874
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9812609071
MESH:D003329 Coronary Vasospasm capecitabine 5.6117465463
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6410525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.648888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.8118551238
MESH:D003556 Cystitis Cyclophosphamide 4.7712913760 16413132 18433785 16989017 18372110 11948286 12388444 18093676 15276878 18710439 16614059 17010015 10498854 10700343 18295254 15643279 17979934 12161096 16651033 18483878
MESH:D007644 Darier Disease Fluorouracil 4.5816733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9015213294
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.8819470301 17244072 17100760
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 6.8811298694 16823706 16780908
MESH:D003877 Dermatitis, Contact Nickel 4.442952479
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9010990075 15331540 11751995
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1618772604
MESH:D003924 Diabetes Mellitus, Type 2 alpha-Tocopherol 3.7116506275
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.7318551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.7319641884 1733752
MESH:D004362 Drug Toxicity Cisplatin 8.2915033597 19839026 12649298 12231392
MESH:D004362 Drug Toxicity Gentamicins 8.2911033412 15033597
MESH:D004421 Dystonia Valproic Acid 3.851851702
MESH:D004802 Eosinophilia Cyclophosphamide 4.0111006010
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.953659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.7116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.8320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.416426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.097750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.853659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.0412903497
MESH:D004938 Esophageal Neoplasms Cisplatin 7.0417638652 16785472 15173087 16481741 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0416481741 16785472 15173087 17638652 16337965
MESH:D005234 Fatty Liver arsenic trioxide 12.0415073043
MESH:D005234 Fatty Liver Cyclosporine 12.0419224547
MESH:D005234 Fatty Liver Valproic Acid 12.0419224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.6716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.938888407 18558336
MESH:D005355 Fibrosis Cyclosporine 8.4812639820 12168785
MESH:D005355 Fibrosis Emodin 8.4819474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0616904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Fenretinide 3.7616187019
MESH:D005910 Glioma Fluorouracil 2.7916145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3011389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8315172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.5215464296 15102660
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5215162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 9.7019898482
MESH:D034381 Hearing Loss Gentamicins 9.7017868369 19130971 18024279 15968427
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006467 Hemophilia A Cyclophosphamide 5.0811918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3214986274
MESH:D015658 HIV Infections Nickel 3.7117263646
MESH:D006689 Hodgkin Disease Cisplatin 7.2016200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 7.2017606976 16135485
MESH:D006849 Hydrocephalus Valproic Acid 4.6617688650
MESH:D053565 Hypercalciuria Gentamicins 5.5017652376
MESH:D006973 Hypertension Cyclosporine 2.0210903974
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4216612254
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1216076520
MESH:D007248 Infertility, Male Cyclophosphamide 6.627193160 16517039
MESH:D007248 Infertility, Male vinclozolin 6.6216467254
MESH:D007249 Inflammation Nickel 3.3216166738
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 12.6115464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 12.6118842672
MESH:D007674 Kidney Diseases Cisplatin 13.6112231392 18289764 15190930 12649298 19839026
MESH:D007674 Kidney Diseases Cyclosporine 13.618314463 10903974 18776723
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 13.6118617210 15834431
MESH:D007674 Kidney Diseases Gentamicins 13.6118289764 19349640 17934191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.4412371664
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 16.4418055543 9667754
MESH:D007680 Kidney Neoplasms Fluorouracil 16.4416985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 11.3011231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 11.3011231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.2910219319
MESH:D007938 Leukemia arsenic trioxide 6.2615070760
MESH:D007938 Leukemia Cyclophosphamide 6.2610602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4117296974 18587576 17008537 17802794 17658394 18172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.4312560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 9.4317077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.1114633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 8.1110373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.5719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7817050201 20471514 16467208 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0816823087 11468182 17869043 12018890 15622746 19035177 12679006 16331271 17649720 16112521 12712474 17107899 19075265 11161223 19642359 15336539 9834237 16330433 15213294 15748426 16891316 16966277 17712046 19225113 17217047
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1516882451
MESH:D007970 Leukopenia Cyclophosphamide 4.7510052129 11830472
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8316707609
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D008106 Liver Cirrhosis, Experimental Emodin 3.0915288473
MESH:D008113 Liver Neoplasms arsenic trioxide 4.4614682389
MESH:D008113 Liver Neoplasms Fluorouracil 4.4618383874 16603448 15113037 17045692
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.6120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1915213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0517228818
MESH:D008175 Lung Neoplasms alpha-Tocopherol 6.3616401635
MESH:D008175 Lung Neoplasms arsenic trioxide 6.3619825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 6.3617849452
MESH:D008175 Lung Neoplasms Cisplatin 6.366189445 11798837 17225452
MESH:D008175 Lung Neoplasms Fluorouracil 6.3615246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5815086387
MESH:D008223 Lymphoma Cyclophosphamide 3.6912854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4016675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0011911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9411161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.1915591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 6.1910697514
MESH:D008545 Melanoma Carboplatin 5.2612040289 16225601 11712820 16342250
MESH:D008545 Melanoma Cisplatin 5.2618505091 12374674 17761969 11135225 16809738 12883367 17023156 18176117 16432458 16248763 15577323 18332650 12393984
MESH:D008545 Melanoma Fenretinide 5.2616270382
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.5916388313
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0418803445 18765137
MESH:D009062 Mouth Neoplasms Fenretinide 8.4116274795
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4116757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9615949261 14977855 19417148 11468182 19549372
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.0618694830
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.848888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0216882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.0217596541
MESH:D009203 Myocardial Infarction alpha-Tocopherol 4.0419595682
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.6518551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7616624393
MESH:D009362 Neoplasm Metastasis capecitabine 4.0412972520
MESH:D009369 Neoplasms capecitabine 18.4916374040
MESH:D009369 Neoplasms Carboplatin 18.4918854779 17925555
MESH:D009369 Neoplasms Cisplatin 18.4916773208
MESH:D009369 Neoplasms Cyclophosphamide 18.4918854779
MESH:D009369 Neoplasms Fenretinide 18.4915958647 17353921
MESH:D009369 Neoplasms Fluorouracil 18.4918239605 18600527 16928823
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5719196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1118481113 19348381
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8810525206
MESH:D009436 Neural Tube Defects Valproic Acid 6.8816359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 6.938761367
MESH:D009447 Neuroblastoma Cyclophosphamide 6.9315176712 8761367 16115947
MESH:D017599 Neuroectodermal Tumors Carboplatin 18.0112837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 18.018761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 18.018761367 12837982
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4716303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3016436463
MESH:D009503 Neutropenia Cyclophosphamide 4.138291058
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.2516049721 12819281
MESH:D009845 Oligospermia Cyclophosphamide 4.5016517039
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.6912452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms Cisplatin 7.6919769630 15464296 6897625 17225452
MESH:D010051 Ovarian Neoplasms Fenretinide 7.6916133793
MESH:D010146 Pain Cyclophosphamide 3.4612161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.5415580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.5419003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 15.5411332152
MESH:D010190 Pancreatic Neoplasms Fenretinide 15.5415580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.5416929163 19003803 15113037 16500647
MESH:D010235 Paraganglioma arsenic trioxide 3.9719927285
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6921297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.0220603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.0218220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2019131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.2017136230
MESH:D011471 Prostatic Neoplasms Fenretinide 2.2017024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.2018626508 19082440
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Gentamicins 4.5315033597
MESH:D019310 Pseudolymphoma Valproic Acid 4.3312752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011657 Pulmonary Eosinophilia alpha-Tocopherol 5.7814606601
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2016636934
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8315538739 16160472 18286688 18722050
MESH:D051437 Renal Insufficiency Cisplatin 9.9715464296
MESH:D051437 Renal Insufficiency Gentamicins 9.9717132701 15728788
MESH:D012162 Retinal Degeneration Fenretinide 4.2516303925
MESH:D012173 Retinitis Gentamicins 6.0618644591
MESH:D012174 Retinitis Pigmentosa alpha-Tocopherol 3.9116849425
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9819155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.6716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.6714601052
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6316636934
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4718551238
MESH:D012640 Seizures Valproic Acid 5.4715475178 1511512 17978042 3137016 11738929 14763951 16876388 11044598
MESH:D012878 Skin Neoplasms Fenretinide 3.4016467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3016517039
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3312833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3617007042
MESH:D013274 Stomach Neoplasms Cisplatin 3.3615958060 18396642 17522103
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3617522103 15786421 17498489 17172411 16424979 18567086 16951190 19015929 18396642 19084572
MESH:D015173 Supratentorial Neoplasms Carboplatin 11.7712837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 11.7712837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9319014326
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8116280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7515213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.0217262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.313119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.9616049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.9620435036 12973940 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 14.9615464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 14.9614692829
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 14.9616720286
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.448888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1010091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 14.9816803524
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 14.9816154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 14.9816803524
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4015577323
MESH:D015837 Vestibular Diseases Gentamicins 5.3218776599
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
REACT:17015 Metabolism of proteins
KEGG:04145 Phagosome
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00025 - Antihemophilic Factor Coagulants;Thrombotic Agents
DB00031 - Tenecteplase Thrombolytic Agents
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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