AutismKB 2.0

Annotation Detail for DGCR14


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Basic Information Top
Gene Symbol:DGCR14 ( DGCR13,DGS-H,DGS-I,DGSH,DGSI,ES2,Es2el )
Gene Full Name: DiGeorge syndrome critical region gene 14
Band: 22q11.21|22q11.2
Quick LinksEntrez ID:8220; OMIM: 601755; Uniprot ID:DGC14_HUMAN; ENSEMBL ID: ENSG00000100056; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DGCR14 mRNAaffects expression 21346803
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of DGCR14 mRNAincreases expression 15336504
D004041 Dietary Fats Dietary Fats results in decreased expression of DGCR14 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of DGCR14 mRNAdecreases expression 18042831
D012643 Selenium Selenium results in increased expression of DGCR14 mRNAincreases expression 19244175
D013467 Sulindac Sulindac results in increased expression of DGCR14 mRNAincreases expression 11906190
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DGCR14 mRNAdecreases expression 11489354
D014810 Vitamin E Vitamin E results in increased expression of DGCR14 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1814514962 15322242 11752688
MESH:D058186 Acute Kidney Injury Sulindac 4.567897758
MESH:D000230 Adenocarcinoma Sulindac 3.1611910360
MESH:D000236 Adenoma Sulindac 3.9110223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.8315623613 19003578 17611924 11535846 16460482 11874996 12394442
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001913 Bowen's Disease Sulindac 5.7311207687
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Sulindac 1.9616642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915340226 8697196 12621046 15668235 16354765
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms Sulindac 2.9512458338 12902858
MESH:D015179 Colorectal Neoplasms Sulindac 2.6910666051 11197048 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5420055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5419769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003930 Diabetic Retinopathy Sulindac 5.4612861449 17621415
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004715 Endometriosis Sulindac 9.9615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.969294722 10568697
MESH:D004938 Esophageal Neoplasms Sulindac 3.1812235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 3.4818296743 17967931 19551842 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.8214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.4719069698
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2911910360
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9516080930
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 18606429 8697196 16959395
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007249 Inflammation Dietary Fats 9.0720412841
MESH:D007249 Inflammation Sulindac 9.073291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.0712200463 12878042
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2511836018 18457598
MESH:D007414 Intestinal Neoplasms Sulindac 4.8612584176 10223192 12351151 10213222 12628509 12663524
MESH:D007417 Intestinal Polyps Sulindac 5.2511245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Vitamin E 2.9312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3612468960
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4016169303
MESH:D008107 Liver Diseases Sulindac 3.0716867024 14986274
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Sulindac 3.6419359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6419555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 3.6411062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D019636 Neurodegenerative Diseases Sulindac 4.4717266991 16850258
MESH:D009765 Obesity Dietary Fats 2.3321332399 11836018 19632207 18674790 17217161 20132043 20518802 18457598 16723640
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6612819281 16049721
MESH:D010146 Pain Sulindac 3.993291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4211504793 16820089
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.928532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9216192470
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014594 Uterine Neoplasms Sulindac 4.8818645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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